Results 81 to 90 of about 314,024 (302)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Employment Incentives to Support “Employment First” [PDF]

Global Journal of Intellectual & Developmental Disabilities, 2018
As the nation moves to implement the “Employment First†initiative for citizens who have intellectual disability, one must question whether there are sufficient numbers of community based jobs to support the needs of individuals who have intellectual disability.
openaire   +1 more source

[How can the mentally ill achieve sustained employment? Supported employment versus pre-vocational training]

, 2012
People with severe mental disorders are often without work, although work may have a positive effect on their health. The paper presents some results in this field from the German S3 guidelines on psychosocial therapies.
Brieger, P, Hoffmann, H
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Evaluation of the Methodology Supported Employment in Promentor Program (UAM-PRODIS). Competence Setting

Siglo Cero, 2016
In this article are presented the results of research on the fit between the job and the skills of workers with intellectual disabilities, in order to identify factors that affect the maintenance of the workplace.
Dolores IZUZQUIZA GASSET, Pablo RODRÍGUEZ HERRERO   +1 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A randomized controlled trial protocol for evaluating the feasibility, acceptability, and work outcomes of individualized placement and support adapted for autistic adults in the community

Contemporary Clinical Trials Communications
Relatively few autistic adults, including those with average intellectual abilities, are competitively employed, meaning that they hold jobs together with non-disabled workers and receive comparable wages and benefits.
Marjorie Solomon, Jo A. Yon-Hernández, Steve Ruder, Susan R. McGurk, Daniel Tancredi, Yukari Takarae, Aubyn C. Stahmer   +6 more
doaj   +1 more source

Supported employment among veterans with serious mental illness: the role of cognition and social cognition on work outcome

Schizophrenia Research: Cognition, 2014
Unemployment is a primary functional deficit for the majority of adults with schizophrenia. Research indicates that over two-thirds of adults living in the community with schizophrenia are unemployed.
L. Felice Reddy, Robert S. Kern
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

International employment schemes for people with mental health problems

BJPsych International, 2015
It has been recognised that work is a positive factor for mental health since the days of Galen (2nd century CE). It was central to the theories and practice of William Tuke at the Retreat in York (founded 1796) and has continued in different forms as a ...
Bob Grove
doaj   +1 more source