Screening and epitope characterization of Nidogen‐2‐specific nanobodies
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Flexibilizing the Termination of the Employment Contract: Pros and Cons [PDF]
The changes in the Romanian Labour Code appear to be a way of implementing the concept of flexicurity in our system of law. And among all institutions changed by the new law, probably the one related to termination of employment has the most dramatic ...
Raluca DIMITRIU
core
Preliminary Report: Worker Rights Consortium Inquiry into Alleged Labor Rights Violations at Rising Sun Kenya EPZ (Kenya) [PDF]
Preliminary report detailing alleged labor rights violations at a textiles factory in Kenya, a producer of goods for Steve and Barry’s University ...
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Specific Information, General Information, and Employment Matches Under Uncertainty [PDF]
Employment matches under uncertainty are typically accompanied by opportunities for information acquisition. Workers can acquire specific information about productivity lotteries at the firm or general information affecting their probabilistic beliefs ...
W. Kip Viscusi
core
China Employment Law Update - October 2017 [PDF]
In This Issue: Social Insurance Updates: Compliance Rates Remain Low and China–Netherlands Social Security Treaty Comes into Force Long-term Work Permits Available in China Work Permit Requirements Clarified for Foreign Nationals Working with Foreign ...
Baker & McKenzie
core +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Breaking New Ground in Hungary: Summary of Selected Provisions of the Hungarian Labour Legislation [PDF]
[Excerpt] Hungarian labour law has gone through significant changes in the last decade and become one of the most developing areas of Hungarian law. Since the end of the communist regime, the labour law legislation has had to cope with the challenges of ...
Baker & McKenzie
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source

