Results 41 to 50 of about 124,240 (288)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Il vuoto, l’apparente, il simulacro: tre considerazioni per una teoria kantiana della letteratura

Comparatismi, 2018
Questo lavoro intende tracciare le prime linee di sviluppo di una possibile teoria kantiana della letteratura. Le prime tre sezioni saranno dedicate alla discussione della Kritik der Urteilskraft (Critica del giudizio), la quarta discuterà brevemente i ...
Marco Carmello
doaj   +1 more source

Void: for Orchestra [PDF]

, 2015
In astronomy, a void is an area in outer space which contains no galaxies. These are vast expanses of darkness and emptiness. This orchestral piece, simply titled void, attempts to describe such an area through various musical methods: long sustained ...
Aragon, Jared
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Conceptualizing 'Thirdplace': Exploring Embedded Narrations in Between a Spatial Trilogy

Megaron, 2017
The question of how space will be produced, up until this day, has been answered through discourses of 'place' developed against the Cartesian space. These discourses have been questioned within a wide framework that intends to consider space in relation
Senem Kaymaz Koca, Jonathan Hale
doaj   +1 more source

Superspace Dynamics and Perturbations Around "Emptiness"

, 1993
Superspace parametrized by gauge potentials instead of metric three-geometries is discussed in the context of the Ashtekar variables. Among other things, an "internal clock" for the full theory can be identified. Gauge-fixing conditions which lead to the
Chang, Lay Nam, Soo, Chopin
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Emptiness Is to Womanism as Purple Is to Lavender: Buddhist Womanism Revisited in Alice Walker’s Taking the Arrow Out of the Heart

Religions
This paper argues that the philosophy of Buddhist emptiness not only finds expression in Alice Walker’s Taking the Arrow Out of the Heart with its two most salient manifestationsdependent origination and impermanence, but is applied to alleviate ...
Zhi Huang, Zier Zhuang
doaj   +1 more source

Intensità nello spazio urbano

Ri-vista: Ricerche per la Progettazione del Paesaggio, 2021
Changes affect the contemporary habitat, leading to a revolution in behavior with exceptional impacts in terms of speed and intensity on the redefinition of forms and functions of space.
Gianni Celestini
doaj   +1 more source