Results 41 to 50 of about 374,243 (339)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Effect of induced mutagenesis in M1 and M2 generations of cumin (Cuminum cyminum L.)
Electronic Journal of Plant Breeding, 2023 Cumin is an important spice that has been used for centuries in various cuisines around the world. Two cumin varieties (GC 3 and GC 4) were subjected to mutation to understand macromutational modifications.
H. N. Patel1*, M. P. Patel2, N. V. Soni1, N. B. Patel1, A. M. Patel3 and N. I. Patel4
doaj +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source
, 1950 This report reviews the Expectation Maximization EM algorithm and applies it to the data segmentation problem yielding the Expectation Maximization Segmentation EMS algorithm The EMS algorithm requires batch processing of the data and can be applied to ...
Kramer, Robert
core +1 more source
Autophagosome marker, LC3, is released extracellularly via several distinct pathways
FEBS Open Bio, EarlyView.This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
Amish Workarounds: Toward a Dynamic, Contextualized View of Technology Use
The Journal of Amish and Plain Anabaptist Studies, 2014 Interviews with northern Indiana Amish business owners reveal a tendency to create complex technological workarounds that allow them to abide by shared religious values while remaining competitive in the marketplace.
Lindsay Ems
doaj
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
Open Access Emergency Medicine, 2023 Christian Angelo I Ventura,1 Edward E Denton2,3 1Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; 2Department of Emergency Medicine, College of Medicine, University of Arkansas for Medical ...
Ventura CAI, Denton EE
doaj