Results 41 to 50 of about 62,727 (249)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Amish Workarounds: Toward a Dynamic, Contextualized View of Technology Use

The Journal of Amish and Plain Anabaptist Studies, 2014
Interviews with northern Indiana Amish business owners reveal a tendency to create complex technological workarounds that allow them to abide by shared religious values while remaining competitive in the marketplace.
Lindsay Ems
doaj  

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Efeitos biológicos da Pfaffia glomerata (Spreng.) Pedersen e da Pfaffia paniculata (Martius) Kuntze (Amaranthaceae)

Acta Scientiarum: Biological Sciences, 2008
A Pfaffia glomerata (Spreng.) Pedersen e da Pfaffia paniculata (Martius) Kuntze (Amaranthaceae) são plantas nativas da região alagada das ilhas de Porto Rico, Paraná, Brasil. São utilizadas na medicina popular como tônico, afrodisíaco e antidiabético.
Nádia Regina Alvim, Kely Christiane Tavares da Cunha, Lúcia Eliane Ranieri Cortez, Roberto Barbosa Bazotte, Luis Carlos Marques, Diógenes Aparício Garcia Cortez   +5 more
openaire   +1 more source

Русск. бить баклуши и лит. dinderį (dinderius) mušti

Baltistica, 2011
RUS. БИТЬ БАКЛУШИ UND LIT. DINDERĮ (DINDERIUS) MUŠTI ZusammenfassungIn dem Artikel werden die Gesetzmässigkeiten der Bildung von der russisch-litauischen Isofrasem бить баклуши – dinderį (dinderius) mušti behandelt. Die frasembildenden Charakteristi­ken der Komponenten dieser Frasemen werden auf folgende Weise bestimmt; die Substantivkom­ponenten mit ...
openaire   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

“Why Would You Want a Baby When You Could Have a Dog?” Voluntarily Childless Women’s “Peternal” Feelings, Longing and Ambivalence [PDF]

Social Sciences, 2019
This article explores voluntarily childless women’s experiences and understandings of human-animal interactions and their attitudes towards companion animals. It draws on interviews with 15 Swedish women who expressed a lack of “maternal” feelings and therefore had remained voluntarily childless, or childfree (used here as two interchangeable concepts).
Helen Peterson, Kristina Engwall
openaire   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Dėl žemaičių a, о (= ide. o, ā) kamieno būdvardžių perėjimo į a, o kamieną

Baltistica, 2011
К ВОПРОСУ О ПЕРЕХОДЕ ИМЕН ПРИЛАГАТЕЛЬНЫХ С ОСНОВАМИ НА a, о В ПРИЛАГАТЕЛЬНЫЕ С ОСНОВАМИ НА а, о В ЖЕМАЙТСКИХ ГОВОРАХ ЛИТОВСКОГО ЯЗЫКАРезюмеНекоторые имена прилагательные жемайтских говоров свои основы на a, o преобра­зовали в основы на а, о, напр., kur̃tas, kurtà (литер, яз. kur̃čias, kurčià) „глухой, глухая“.
openaire   +2 more sources