Results 51 to 60 of about 363,935 (339)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Studi Irlandesi, 2011 Studi irlandesi. A Journal of Irish Studies, No 1 (2011)
openaire +2 more sources
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Amish Workarounds: Toward a Dynamic, Contextualized View of Technology Use
The Journal of Amish and Plain Anabaptist Studies, 2014 Interviews with northern Indiana Amish business owners reveal a tendency to create complex technological workarounds that allow them to abide by shared religious values while remaining competitive in the marketplace.
Lindsay Ems
doaj
Vibration Analysis of a Hybrid Levitation Pod with Compressor Unbalanced Force in Hyperloop System [PDF]
International Journal of Railway Research, 2022 Hyperloop Transportation Technology (HTT) is a worldwide invention proposed by Elon Musk in the last decade. This system works based on moving an ultra-high-speed capsule-shaped vehicle called a “pod” into low-air pressure tubes.
Hamed Petoft, Vahid Fakhari, Abbas Rahi
doaj
Comparing the Online Learning Capabilities of Gaussian ARTMAP and Fuzzy ARTMAP for Building Energy Management Systems [PDF]
, 2013 Recently, there has been a growing interest in the application of Fuzzy ARTMAP for use in building energy management systems or EMS. However, a number of papers have indicated that there are important weaknesses to the Fuzzy ARTMAP approach, such as ...
Howe, Joseph Mark, Mokhtar, Maizura
core +1 more source
The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity
Molecular Oncology, EarlyView.Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause +6 more
wiley +1 more source
Studi Irlandesi, 2011 Studi irlandesi. A Journal of Irish Studies, No 1 (2011)
openaire +2 more sources
FEBS Open Bio, EarlyView.Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley +1 more source
FEBS Open Bio, EarlyView.Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli +4 more
wiley +1 more source