Results 111 to 120 of about 338,860 (400)

Regulation of EMT by TGFβ in cancer [PDF]

FEBS Letters, 2012
Transforming growth factor‐β (TGFβ) suppresses tumor formation since it inhibits cell growth and promotes apoptosis. However, in advanced cancers TGFβ elicits tumor promoting effects through its ability to induce epithelial‐mesenchymal transition (EMT) which enhances invasiveness and metastasis; in addition, TGFβ exerts tumor promoting effects on non ...
Carl-Henrik Heldin, Aristidis Moustakas, Aristidis Moustakas, Michael Vanlandewijck   +3 more
openaire   +3 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

MSPB: a longitudinal multi-sensor dataset with phenotypic trait measurements from honey bees

Scientific Data
We present a one-year-long multi-sensor dataset collected from honey bee colonies (Apis mellifera) with rich phenotypic measurements. Data were collected non-stop from April 2020 to April 2021 from 53 hives located at two apiaries in Québec, Canada.
Yi Zhu, Mahsa Abdollahi, Ségolène Maucourt, Nico Coallier, Heitor R. Guimarães, Pierre Giovenazzo, Tiago H. Falk   +6 more
doaj   +1 more source

Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics

Pharmaceutics, 2019
Viruses have recently emerged as promising nanomaterials for biotechnological applications. One of the most important applications of viruses is phage display, which has already been employed to identify a broad range of potential therapeutic peptides ...
Esen Sokullu, Hoda Soleymani Abyaneh, Marc A. Gauthier   +2 more
doaj   +1 more source

A Heterogeneous Multiscale Method for Power System Simulation Considering Electromagnetic Transients [PDF]

arXiv, 2023
Traditional dynamic security assessment faces challenges as power systems are experiencing a transformation to inverter-based-resource (IBR) dominated systems, for which electromagnetic transient (EMT) dynamics have to be considered. However, EMT simulation is time-consuming especially for a large power grid because the mathematical model based on ...
arxiv  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

UrBAN: Urban Beehive Acoustics and PheNotyping Dataset

Scientific Data
In this paper, we present a multimodal dataset obtained from a honey bee colony in Montréal, Quebec, Canada, spanning the years of 2021 to 2022. This apiary comprised 10 beehives, with microphones recording more than 3000 hours of high quality raw audio,
Mahsa Abdollahi, Yi Zhu, Heitor R. Guimarães, Nico Coallier, Ségolène Maucourt, Pierre Giovenazzo, Tiago H. Falk   +6 more
doaj   +1 more source

Coupling-Strength-Independent Long-Period Grating Designs for THz-Bandwidth Optical Differentiators

IEEE Photonics Journal, 2013
A novel design of THz-bandwidth all-optical arbitrary-order temporal differentiators using long period fiber/waveguide gratings (LPGs) is proposed and numerically demonstrated.
Reza Ashrafi, Ming Li, Jose Azana
doaj   +1 more source

Mathematical Modeling of Plasticity and Heterogeneity in EMT [PDF]

arXiv, 2019
Epithelial-Mesenchymal Transition (EMT), and the corresponding reverse process, Mesenchymal-Epithelial Transition (MET), are dynamic and reversible cellular programs orchestrated by many changes at biochemical and morphological levels. A recent surge in identifying the molecular mechanisms underlying EMT/MET has led to the development of various ...
arxiv  

Salt intake induces epithelial-to-mesenchymal transition of the peritoneal membrane in rats [PDF]

, 2010
Methods. Twenty-eight Wistar rats were randomized to a normal salt (NS) or a high salt (HS) intake. NS and HS rats had free access to tap water or NaCl 2% as drinking water, respectively.
Consoli, Claudia, Passlick-Deetjen, Jutta, Pletinck, Anneleen, Steppan, Sonja, Topley, Nick, Van Biesen, Wim, Van Landschoot, Maria, Vanholder, Raymond   +7 more
core   +2 more sources