Results 111 to 120 of about 366,025 (373)

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

The Extended Mind Thesis and Mechanistic Explanations [PDF]

, 2013
The Extended Mind Thesis (EMT) is traditionally formulated against the bedrock of functionalism, and ongoing debates are typically bogged down with questions concerning the exact relationship between EMT and different versions of functionalism.
Fazekas, Péter
core  

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

FPGA-SDR Integration and Experimental Validation of a Joint DA ML SNR and Doppler Spread Estimator for 5G Cognitive Transceivers

IEEE Access, 2019
In a multi-connected, multi-technology, and pervasive mobile infrastructure, such as what is being planned for 5G, artificial intelligence and cognition will play a major role.
Haithem Haggui, Sofiene Affes, Faouzi Bellili   +2 more
doaj   +1 more source

Energy-Momentum Tensor of Cosmological Fluctuations during Inflation

, 2003
We study the renormalized energy-momentum tensor (EMT) of cosmological scalar fluctuations during the slow-rollover regime for chaotic inflation with a quadratic potential and find that it is characterized by a negative energy density which grows during ...
A. Tronconi, A. Vilenkin, A.A Starobinsky, A.A. Starobinsky, A.A. Starobinsky, A.A. Starobinsky, A.D. Linde, A.H. Guth, C.L. Bennett, D. Lyth, E. Stewart, F. Finelli, F. Finelli, F. Finelli, F. Finelli, F. Lucchin, G. Geshnizjani, G. Marozzi, G. P. Vacca, G. Rigopoulos, G. Venturi, H. Kodama, H. Noh, H.R. Lewis, Jr., H.V. Peiris, J. Maldacena, J. Martin, J.-c. Hwang, J.M. Stewart, L. Parker, L.R. Abramo, L.R. Abramo, L.R. Abramo, L.R. Abramo, M. Bruni, N.C. Tsamis, R. Abramo, R. Abramo, S. Habib, S. Habib, S.W. Hawking, V. Acquaviva, V.F. Mukhanov, V.F. Mukhanov, V.F. Mukhanov, V.F. Mukhanov, V.F. Mukhanov, Y. Nambu   +47 more
core   +1 more source

Porous Bi2S3 Bulk With Excellent Thermoelectric Performance by Solid States Replacement and Low Melting‐Point Metal Volatilization

Advanced Materials, EarlyView.
By introducing FeCoNi medium‐entropy alloy, the bismuth sulfide (Bi2S3) material achieves a record‐high ZT of 1.1 at 773 K, owing to the solid‐states replacement reaction and the volatilization of low melting‐point metal. This strategy is also applicable to other sulfur‐based thermoelectric materials.
Zi‐Yuan Wang, Jun Guo, Yi‐Xin Zhang, Hao Liang, Xing Yang, Rafal E. Dunin‐Borkowski, Fengshan Zheng, Lei Jin, Jing Feng, Zhen‐Hua Ge   +9 more
wiley   +1 more source

Terahertz Volume Plasmon‐Polariton Modulation in All‐Dielectric Hyperbolic Metamaterials

Advanced Optical Materials, EarlyView.
THz volume plasmon‐polariton (VPP) propagation through plasmon‐based hyperbolic metamaterials, made of alternating layers of doped and undoped III‐V semiconductors. Abstract The development of plasmonics and related applications in the terahertz range faces limitations due to the intrinsic high electron density of the standard metals.
Stefano Campanaro, Luca Bursi, Stefano Curtarolo, Arrigo Calzolari   +3 more
wiley   +1 more source

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

EMBO Reports, 2008
The embryonic programme ‘epithelial–mesenchymal transition’ (EMT) is thought to promote malignant tumour progression. The transcriptional repressor zinc‐finger E‐box binding homeobox 1 (ZEB1) is a crucial inducer of EMT in various human tumours, and was ...
U. Burk, Jörg Schubert, U. Wellner, O. Schmalhofer, E. Vincan, S. Spaderna, T. Brabletz   +6 more
semanticscholar   +1 more source

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

Reversing EMT

Kidney International, 2005
Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cell layers lose polarity and cell-cell contacts and undergo a massive cytoskeleton reorganization involving the rho family and the remodeling of the actin microfilament mesh (Thiery, 2002).
openaire   +1 more source