Results 61 to 70 of about 213,806 (248)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

UrBAN: Urban Beehive Acoustics and PheNotyping Dataset

Scientific Data
In this paper, we present a multimodal dataset obtained from a honey bee colony in Montréal, Quebec, Canada, spanning the years of 2021 to 2022. This apiary comprised 10 beehives, with microphones recording more than 3000 hours of high quality raw audio,
Mahsa Abdollahi, Yi Zhu, Heitor R. Guimarães, Nico Coallier, Ségolène Maucourt, Pierre Giovenazzo, Tiago H. Falk   +6 more
doaj   +1 more source

Three-Dimensional Pinecone-like Binder-Free Pt–TiO₂ Nanorods on Ti Mesh Structures: Synthesis, Characterization and Electroactivity towards Ethanol Oxidation

Molecules, 2022
We report here the synthesis of binderless and template-less three-dimensional (3D) pinecone-shaped Pt/TiO2/Ti mesh structure. The TiO2 hydrothermally synthesized onto Ti mesh is composed of a mixture of flower-like nanorods and vertically aligned bar ...
Naser Mohammadi, Juan Carlos Abrego-Martinez, Mohamed Mohamedi   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

MSPB: a longitudinal multi-sensor dataset with phenotypic trait measurements from honey bees

Scientific Data
We present a one-year-long multi-sensor dataset collected from honey bee colonies (Apis mellifera) with rich phenotypic measurements. Data were collected non-stop from April 2020 to April 2021 from 53 hives located at two apiaries in Québec, Canada.
Yi Zhu, Mahsa Abdollahi, Ségolène Maucourt, Nico Coallier, Heitor R. Guimarães, Pierre Giovenazzo, Tiago H. Falk   +6 more
doaj   +1 more source

Reconfigurable photonic generation of broadband chirped waveforms using a single CW laser and low-frequency electronics

Nature Communications, 2018
Producing versatile radio-frequency chirped waveforms often requires complicated techniques. The authors use a fiber-optic frequency-shifting loop to create a low-complexity photonic chirp generator with high bandwidth and fully flexible properties for ...
Hugues Guillet de Chatellus, Luis Romero Cortés, Côme Schnébelin, Maurizio Burla, José Azaña   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics

Pharmaceutics, 2019
Viruses have recently emerged as promising nanomaterials for biotechnological applications. One of the most important applications of viruses is phage display, which has already been employed to identify a broad range of potential therapeutic peptides ...
Esen Sokullu, Hoda Soleymani Abyaneh, Marc A. Gauthier   +2 more
doaj   +1 more source

Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules.

JCI Insight, 2020
SGLT2 inhibitors are beneficial in halting diabetic kidney disease; complete mechanisms is unknown. The epithelial to mesenchymal transition (EMT) is associated with Sirt3 suppression and aberrant glycolysis.
Jinpeng Li, Haijie Liu, Susumu Takagi, Kyoko Nitta, Munehiro Kitada, S. Srivastava, Y. Takagaki, K. Kanasaki, D. Koya   +8 more
semanticscholar   +1 more source