The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation. [PDF]
PLoS ONE, 2012 The epithelial sodium channel (ENaC) is the rate-limiting step for sodium reabsorption across tight epithelia. Cyclic-AMP (cAMP) stimulation promotes ENaC trafficking to the apical surface to increase channel number and transcellular Na(+) transport ...
Robert S Edinger +5 more
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Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4. [PDF]
PLoS ONE, 2015 The membrane-bound serine protease CAP2/Tmprss4 has been previously identified in vitro as a positive regulator of the epithelial sodium channel (ENaC).
Anna Keppner +9 more
doaj +3 more sources
Expression profiles of SGK-1 and α-ENaC in minor salivary glands of subjects with xerostomia [PDF]
Frontiers in Dental MedicineIntroductionEpithelial sodium channel (ENaC) is a major conduit for sodium transport across the cell membrane, and its activity is regulated by multiple factors/mechanisms, including the serum and glucocorticoid-regulated kinase-1 (SGK-1).
Mahmood S. Mozaffari, Rafik Abdelsayed
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The evolutionary path of the epithelial sodium channel δ-subunit in Cetartiodactyla points to a role in sodium sensing [PDF]
Communications BiologyThe epithelial sodium channel (ENaC) is essential for osmoregulation in tetrapod vertebrates. There are four ENaC-subunits (α, β, γ, δ) which form αβγ- or δβγ-ENaCs. While αβγ-ENaC is a ‘maintenance protein’ controlling sodium homeostasis, δβγ-ENaC might
Fynn Zahnow +14 more
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ENaC is a host susceptibility factor to bacterial infections in cystic fibrosis context [PDF]
Communications BiologyCystic fibrosis (CF) is a genetic disease caused by dysfunction in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channel. Patients with CF are hypersusceptible to Mycobacterium abscessus infection, a fast-growing mycobacterium ...
Hamadoun Touré +7 more
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Gi‐DREADD activation decreases Epithelial Na+ channel activity in renal principal cells [PDF]
Physiological ReportsThe activity of the Epithelial Na+ Channel (ENaC) in renal principal cells (PC) fine‐tunes sodium excretion and consequently affects blood pressure. G‐coupled receptors play an important role in regulating ENaC activity.
Tarek Mohamed Abd El‐Aziz +4 more
doaj +2 more sources
Role of epithelial sodium channel-related inflammation in human diseases
Frontiers in Immunology, 2023 The epithelial sodium channel (ENaC) is a heterotrimer and is widely distributed throughout the kidneys, blood vessels, lungs, colons, and many other organs.
Yabin Chen +11 more
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A novel nonsense mutation in the β-subunit of the epithelial sodium channel causing Liddle syndrome
Blood Pressure, 2021 Purpose Liddle syndrome is a hereditary form of arterial hypertension caused by mutations in the genes coding of the epithelial sodium channel – SCNN1A, SCNN1B and SCNN1G.
Štěpán Mareš +7 more
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ADMET and DMPK, 2023 The epithelial sodium channel (ENaC) is a transmembrane protein that regulates the balance of sodium salt levels in the body through its expression in various tissues. The increase in sodium salt in the body is related to the expression of ENaC, thereby
Tias Febriana Hanifa Lestari +4 more
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CRISPR/Cas9-Mediated α-ENaC Knockout in a Murine Pancreatic β-Cell Line
Frontiers in Genetics, 2021 Many ion channels participate in controlling insulin synthesis and secretion of pancreatic β-cells. Epithelial sodium channel (ENaC) expressed in human pancreatic tissue, but the biological role of ENaC in pancreatic β-cells is still unclear.
Xue Zhang +7 more
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