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Enantiomers and Their Resolution [PDF]

Encyclopedia, 2022
Enantiomers share the same chemical formula but have different chemical structures, i.e., type of isomers. Enantiomers are present in several drugs, perfumes, food, and are a fundamental part of biomolecules.
Rodrigo Santos, Karen V. Pontes, Idelfonso B. R. Nogueira   +2 more
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Synthesis of novel phthalimido oxime pseudoesters and evaluation of their cytotoxicity [PDF]

Journal of the Serbian Chemical Society, 2020
A series of novel optically pure oxime pseudoesters derivatives were synthesized by the reaction of substitute keto oximes with various N-substituted α-amino acids chlorides in the presence of triethylamine and dichloromethane at 0°C, and their ...
Mehrez Asma, Chakroun Ibtissem, Mtat Dalila, Ben Mansour Hédi, Touati Ridha   +4 more
doaj   +1 more source

An electronic circular dichroism spectroscopy method for the quantification of L- and D-amino acids in enantiomeric mixtures [PDF]

Royal Society Open Science, 2021
Rapid quantitative analysis of single chiral amino acid (aa) was achieved using circular dichroism (CD) with data analysis by standard calibration curve.
Ruiwen Ding, Jianxi Ying, Yufen Zhao
doaj   +1 more source

Probing Fast Enantio-Recognition of Drugs with Multiple Chiral Centers by Electrospray-Tandem Mass Spectrometry and Its Mechanism

Applied Sciences, 2022
Chiral drugs are very complex substances since individual enantiomers may differ in pharmacological and toxic effects, making it necessary to analyze enantiomers separately.
Hechen Wang, Xiaolei Chen, Yali Wang, Lu Wang, Zhangzhao Gao, Haihong Hu, Lushan Yu, Su Zeng, Yu Kang   +8 more
doaj   +1 more source

(±)-Cryptamides A–D, Four Pairs of Novel Dopamine Enantiomer Trimers from the Periostracum Cicadae

Molecules, 2022
Four pairs of novel dopamine enantiomer trimers, (±)-cryptamides A–D (1–4), and 10 pairs of previously described dopamine enantiomer dimers (5–14) were isolated from the Periostracum cicadae, the cast-off shell of the insect Cryptotympana pustulata ...
Junjian Luo, Wenjun Wei, Pan Wang, Tao Guo, Suiqing Chen, Liping Zhang, Shuying Feng   +6 more
doaj   +1 more source

Synthesis of 6-Halo-Substituted Pericosine A and an Evaluation of Their Antitumor and Antiglycosidase Activities

Marine Drugs, 2022
The enantiomers of 6-fluoro-, 6-bromo-, and 6-iodopericosine A were synthesized. An efficient synthesis of both enantiomers of pericoxide via 6-bromopericosine A was also developed.
Yoshihide Usami, Yoshino Mizobuchi, Mai Ijuin, Takeshi Yamada, Mizuki Morita, Koji Mizuki, Hiroki Yoneyama, Shinya Harusawa   +7 more
doaj   +1 more source

Synthesis of the Enantiomers of Thioridazine [PDF]

SynOpen, 2020
Thioridazine, a well-known antipsychotic drug, has shown promising effects on several bacterial strains (including Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus). Suppressive effects towards selected cancer cell-lines have also been reported.
Simen Antonsen, Erling B. Monsen, Kirill Ovchinnikov, Jens M. J. Nolsøe, Dag Ekeberg, Jette E. Kristiansen, Dzung B. Diep, Yngve Stenstrøm   +7 more
openaire   +5 more sources

The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy

Frontiers in Pharmacology, 2022
In an ex vivo rat ocular hypertension (OHT) model, the neurosteroid allopregnanolone (AlloP) exerts neuroprotective effects via enhancement of both GABAA receptors and autophagy.
Makoto Ishikawa, Makoto Ishikawa, Toru Nakazawa, Toru Nakazawa, Toru Nakazawa, Toru Nakazawa, Hiroshi Kunikata, Hiroshi Kunikata, Kota Sato, Kota Sato, Takeshi Yoshitomi, Takeshi Yoshitomi, Kathiresan Krishnan, Douglas F. Covey, Douglas F. Covey, Douglas F. Covey, Douglas F. Covey, Charles F. Zorumski, Charles F. Zorumski, Charles F. Zorumski, Yukitoshi Izumi, Yukitoshi Izumi, Yukitoshi Izumi   +22 more
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Systematic Investigations on Continuous Fluidized Bed Crystallization for Chiral Separation

Crystals, 2020
A recently developed continuous enantioseparation process utilizing two coupled fluidized bed crystallizers is systematically investigated to identify essential correlations between different operation parameters and the corresponding process performance
Erik Temmel, Jonathan Gänsch, Andreas Seidel-Morgenstern, Heike Lorenz   +3 more
doaj   +1 more source

A Validated Chiral LC–MS/MS Method for the Enantioselective Determination of (S)-(+)- and (R)-(-)-Ibuprofen in Dog Plasma: Its Application to a Pharmacokinetic Study

Pharmaceutics, 2023
The purpose of this study was to develop a method for simultaneously separating ibuprofen enantiomers using electrospray ionization (ESI) liquid chromatography with tandem mass spectrometry (LC–MS/MS).
Sanghee Choi, Wang-Seob Shim, Jiyoung Yoon, Doowon Choi, Jinseong Lee, Soo-Heui Paik, Eun-Kyoung Chung, Kyung-Tae Lee   +7 more
doaj   +1 more source