Results 101 to 110 of about 88,128 (341)

Quantitative Study of Enantiomer-Specific State Transfer [PDF]

, 2022
Ju Hyeon Lee, Johannes Bischoff, Alicia Hernandez-Castillo, Boris G. Sartakov, Gerard Meijer, Sandra Eibenberger   +5 more
openalex   +1 more source

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Atroposelective Suzuki–Miyaura Coupling to Form 2‐Amino‐2′‐Hydroxybiphenyls Enabled by sRuPhos

Angewandte Chemie, EarlyView.
We report a new chiral phosphine ligand, sRuPhos, which permits the highly enantioselective Suzuki–Miyaura coupling of ortho‐aniline and ortho‐phenol building blocks. This results in 2‐amino‐2′‐hydroxybiphenyls with very high enantiomeric excesses, products that will have application in pharmaceutical synthesis and ligand design for catalysis ...
Hamzah Sharif, Luke A. McCall, Matthew G. Sanders, Robert J. Phipps   +3 more
wiley   +2 more sources

Discovery of a Novel Chromone Enantiomer and the Precursors of Nonactic Acid from the Coral-Reef-Derived Streptomyces sp. SCSIO 66814

Marine Drugs
Three pairs of enantiomers (1–3)—the new 12R-aloesol (1a) and two new fatty acids (2 and 3)—and one new natural product (4) together three known compounds (5–7) were isolated from a coral-reef-derived Streptomyces sp. SCSIO 66814.
Wenping Ding, Yanqun Li, Xingyu Li, Jiajia Yin, Songbiao Shi, Xinpeng Tian, Si Zhang, Hao Yin   +7 more
doaj   +1 more source

Influence Spatial Degeneracy on Rotational Spectroscopy Three Wave Mixing and enantiomeric state separation of Chiral Molecules

, 2018
Pulse flip angles are calculated for three wave mixing, three state cycles of chiral molecules to produce optimized free induction decay amplitudes proportional to the enantiomeric excess of a sample, and to produced optimized degree of state specific ...
Lehmann, Kevin K.
core   +1 more source

Luminescent Chiral Molecular Glasses by Melt‐Quenching Enantiopure BINAP

Advanced Science, EarlyView.
Melt‐quenching of enantiopure BINAP yields transparent chiral molecular glasses that retain axial chirality and display blue‐shifted luminescence together with strongly enhanced circularly polarized emission with dissymmetry factors |glum| of ≈10−2.
Nuttaporn Krittametaporn, Philipp Ralle, Dorothea Dierks, Christian Nelle, Suresh K. Vasa, Pascal Kolodzeiski, Rasmus Linser, Andreas Steffen, Sebastian Henke   +8 more
wiley   +1 more source

(Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications

Angewandte Chemie, EarlyView.
In this review, we spotlight recent breakthroughs in α‐polyboron‐substituted carbon‐centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundamental reactivity with the application potential of these extraordinary species, we hope this review will serve as a roadmap for harnessing these unique ...
Nadim Eghbarieh, Nicole Hanania, Pinaki Nad, Tipu Alam, Tamir Kish, Ahmad Masarwa   +5 more
wiley   +2 more sources

Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters

Journal of Lipid Research, 2006
To probe the pathway and specificity of cholesterol absorption, the synthetic enantiomer of cholesterol (ent-cholesterol) and cholesterol were labeled with deuterium, gavaged into hamsters, and measured by negative ion mass spectrometry.
Emily J. Westover, Xiaobo Lin, Terrence E. Riehl, Lina Ma, William F. Stenson, Douglas F. Covey, Richard E. Ostlund, Jr.   +6 more
doaj   +1 more source

Mechanism of action of VP1-001 in cryAB(R120G)-associated and age-related cataracts [PDF]

, 2019
PurposeWe previously identified an oxysterol, VP1-001 (also known as compound 29), that partially restores the transparency of lenses with cataracts. To understand the mechanism of VP1-001, we tested the ability of its enantiomer, ent-VP1-001, to bind ...
Andley, Usha P., Covey, Douglas F., Dunyak, Bryan M., Gestwicki, Jason E., Hamilton, Paul D., Izrayelit, Yevgeniy, Makley, Leah N., McGlasson-Naumann, Brittney, Molnar, Kathleen S., Qian, Mingxing, Su, Bonnie   +10 more
core   +2 more sources

Stereodivergent Access to Aliphatic Nitro Compounds Bearing Multi‐Contiguous Stereocenters via Sequential Catalysis

Advanced Science, EarlyView.
Herein, we report a highly efficient synthesis of aliphatic nitro compounds bearing multi‐contiguous stereocenters in good yields with excellent diastereo‐ and enantio‐selectivities by combining copper‐catalyzed asymmetric conjugate addition of dialkylzinc reagents to nitroalkenes with iridium‐catalyzed asymmetric allylic substitution reaction ...
Jia‐Hao Xie, Yi‐Ming Hou, Zhi‐Jie Wu, Chao Zheng, Shu‐Li You   +4 more
wiley   +1 more source