Results 121 to 130 of about 88,128 (341)

Synthesis, Crystal Structure, Absolute Configuration and Antitumor Activity of the Enantiomers of 5-Bromo-2-chloro-N-(1-phenylethyl)pyridine-3-sulfonamide

Molecules, 2015
Pyridinesulfonamide is an important fragment which has a wide range of applications in novel drugs. R- and S-isomers of 5-bromo-2-chloro-N-(1-phenylethyl)pyridine-3-sulfonamide have been synthesized, and the stereostructures have been researched.
Zhixu Zhou, Linwei Li, Ning Yan, Lei Du, Changshan Sun, Tiemin Sun   +5 more
doaj   +1 more source

Chiral analysis of E‐ε‐viniferin enantiomers, towards a new chemotaxonomic marker of the vine [PDF]

, 2023
Julien Gabaston, Thierry Buffeteau, Agnès Destrac-Irvine, Gregory A. Gambetta, Jean‐Michel Mérillon, Pierre Waffo‐Téguo   +5 more
openalex   +1 more source

Enantioselective Reductive Alkenylation of α‐CF2H (‐CF3) Amino Halides: Rapid Access to Chiral α‐CF2H (‐CF3) Allylamines

Advanced Science, EarlyView.
Difluoromethyl (CF2H) group, the bioisostere of hydroxyl thiol methyl or amide is privileged in medicinal chemistry due to hydrogen‐binding ability and lipophilic, metabolically stable, and chemical inert nature. However, enatioseleceive CF2H introduction remains challenging.
Peng Liu, Kuiliang Li, Yan He, Chen‐Hui Jiang, Ruo‐Xing Jin, Duo‐Duo Hu, Wei‐Cheng Zhao, Xuan Nie, Shang‐Zheng Sun, Xi‐Sheng Wang   +9 more
wiley   +1 more source

Stochastic Approach to Enantiomeric Excess Amplification and Chiral Symmetry Breaking

, 2006
Stochastic aspects of chemical reaction models related to the Soai reactions as well as to the homochirality in life are studied analytically and numerically by the use of the master equation and random walk model. For systems with a recycling process, a
Blackmond D. G., Buhse T., Calvin M., Frank F. C., Goldanskii V. I., Gridnev I. D., Gridnev I. D., Islas J. R., Japp F. R., Lente G., Lente G., Mills M. H., Pasteur L., Pearson K., Press W. H., Saito Y., Saito Y., Saito Y., Saito Y., Saito Y., Sato I., Sato I., Shibata R., Singleton D. A., Singleton D. A., Soai K., Soai K., Soai K., Stryer L., Vollhardt K. P. C.   +29 more
core   +1 more source

enantiomer excess

, 2014
Citation: 'enantiomer excess' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.E02070 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

An Enantiomer of an Oral Small Molecule TSH Receptor Agonist Exhibits Improved Pharmacologic Properties

Frontiers in Endocrinology, 2016
We are developing an orally available small molecule, allosteric TSH receptor (TSHR) agonist for follow up diagnostics of patients with thyroid cancer.
Susanne Neumann, Umesh Padia, Mary Jane Cullen, Elena Eliseeva, Eshel A Nir, Robert F Place, Sarah J Morgan, Marvin C Gershengorn   +7 more
doaj   +1 more source

Enantiospecific Optical Sensing of Terpenes by an Aggregated Atropisomeric Platinum(II) Complex

Angewandte Chemie, EarlyView.
Aggregated metal complexes act as an artificial nose and permit reversible optical sensing of small volatile molecules like R/S‐limonene based on enantiospecific recognition. Abstract Terpenes are unfunctionalized small volatile organic compounds (VOCs) that are naturally abundant, relevant to climate change, and impose potential health risks.
Annika Huber, Alessandro Prescimone, Christof Sparr, Oliver S. Wenger   +3 more
wiley   +2 more sources

Analytical Enantio-Separation of Linagliptin in Linagliptin and Metformin HCl Dosage Forms by Applying Two-Level Factorial Design

Scientia Pharmaceutica, 2016
A novel, stability indicating, reverse phase high-performance liquid chromatography (RP-HPLC) method was developed to determine the S-isomer of linagliptin (LGP) in linagliptin and metformin hydrochloride (MET HCl) tablets (LGP–MET HCl) by implementing ...
Sushant B. Jadhav, Rahul M. Mane, Kalyanraman L. Narayanan, Popatrao N. Bhosale   +3 more
doaj   +1 more source

Tetraaza[7]–[15]helicenes Synthesized by Two‐Step Strategy: Length‐Controlled Chiral π‐Systems Exhibiting Amplified Circularly Polarized Luminescence

Angewandte Chemie, EarlyView.
A modular two‐step strategy provides tetraaza[n]helicenes (n = 7–15) as a homologous series with tunable photophysical and chiroptical properties. Extension beyond n = 11 induces pronounced through‐space π–π interactions, narrowing the energy gap and amplifying circularly polarized luminescence.
Takashi Otani, Yuchen Wu, Kohei Ueda, Yuki Ikeda, Yuna Tada, Natsuna Kinoshita, Takanori Shibata   +6 more
wiley   +2 more sources