Results 141 to 150 of about 107,976 (280)

A combined experimental and theoretical study on realizing and using laser controlled torsion of molecules

, 2009
It is demonstrated that strong laser pulses can introduce torsional motion in the axially chiral molecule 3,5-diflouro-3',5'-dibromo-biphenyl (DFDBrBPh).
Holmegaard, L., Johansson, M. P., Jorgensen, K. A., Kumarappan, V., Madsen, C. B., Madsen, L. B., Poulsen, T. B., Stapelfeldt, H., Viftrup, S. S.   +8 more
core   +1 more source

Tolerance to the bronchoprotective effect of β2 -agonists: Comparison of the enantiomers of salbutamol with racemic salbutamol and placebo [PDF]

, 1999
Donald W. Cockcroft, Beth E. Davis, Veronica A. Swystun, Darcy D. Marciniuk   +3 more
openalex   +1 more source

Time‐Dependent Therapeutic Effect of S‐Ketamine on PTSD Mediated by VTA‐OFC Dopaminergic Neurocircuit

Advanced Science, EarlyView.
This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang, Lei Liu, Jinghao Wang, Jiannan Li, Huiming Li, Rui Wang, Hui Wang, Min Wang, Quanying Liu, Zhongmin Fan, Yunyun Zhang, Xinxin Zhang, Dan Wang, Sa Wang, Rou Xue, Jindong Mao, Min Cai, Pengfei Wei, Hailong Dong, Yumei Wu, Guangchao Zhao   +20 more
wiley   +1 more source

Enantio- and Chemo-Selective HPLC Analysis of Silodosin on an Amylose-Based Chiral Stationary Phase

Molecules
A direct enantio- and chemo-selective high-performance liquid chromatographic method was developed for determining the enantiomeric impurity of the chiral active pharmaceutical ingredient silodosin. The simultaneous separation of enantiomers of silodosin
Daniele Sadutto, Francesca Romana Mammone, Giulia D’Ettorre, Leo Zanitti, Daniela De Orsi, Romina Alfonsi, Francesca Prestinaci, Roberto Cirilli   +7 more
doaj   +1 more source

Stochastic Approach to Enantiomeric Excess Amplification and Chiral Symmetry Breaking

, 2006
Stochastic aspects of chemical reaction models related to the Soai reactions as well as to the homochirality in life are studied analytically and numerically by the use of the master equation and random walk model. For systems with a recycling process, a
Blackmond D. G., Buhse T., Calvin M., Frank F. C., Goldanskii V. I., Gridnev I. D., Gridnev I. D., Islas J. R., Japp F. R., Lente G., Lente G., Mills M. H., Pasteur L., Pearson K., Press W. H., Saito Y., Saito Y., Saito Y., Saito Y., Saito Y., Sato I., Sato I., Shibata R., Singleton D. A., Singleton D. A., Soai K., Soai K., Soai K., Stryer L., Vollhardt K. P. C.   +29 more
core   +1 more source

Directing the Mobility of Guest Molecules in Nanoporous Materials by Linearly Polarized Light

Advanced Science, EarlyView.
The polarization of light is introduced as a further parameter to dynamically and reversibly control the properties of a photoresponsive nanoporous material. It was used to control the mobility of the guest molecules in the pores of a metal–organic framework.
Taher Al Najjar, Chun Li, Yunzhe Jiang, Anna Mauri, Modan Liu, Abhinav Chandresh, Anemar Bruno Kanj, Dragos Mutruc, Wolfgang Wenzel, Stefan Hecht, Mariana Kozlowska, Lars Heinke   +11 more
wiley   +1 more source

Oral fluid with three modes of collection and plasma methamphetamine and amphetamine enantiomer concentrations after controlled intranasal l‐methamphetamine administration [PDF]

, 2015
Matthew N. Newmeyer, Marta Concheiro, José Luiz Costa, Ronald Flegel, David A. Gorelick, Marilyn A. Huestis   +5 more
openalex   +1 more source

Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma

Advanced Science, EarlyView.
IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T. Huse, Bo Chen, Timothy A. Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang   +16 more
wiley   +1 more source

Amino Acid Directed Helical Assemblies of Natural Berberine for Chirality‐Dependent Photodynamic Antibacterial Therapy

Advanced Science, EarlyView.
Helical nanostructures co‐assembled from berberine (BBR) and Fmoc‐Y display supramolecular‐chirality‐dependent photodynamic antibacterial activity. The molecular chirality of Fmoc‐Y organizes achiral BBR into chiral nanofibers, where supramolecular handedness controls bacterial surface adsorption, membrane penetration, intracellular BBR delivery, and ...
Haoqiang Zhao, Jingyi Jiao, Zhixia Wang, Chengyu Shi, Xinran Huang, Yixuan Lin, Haolin Yang, Haimin Lei, Guanghui Ouyang, Minghua Liu   +9 more
wiley   +1 more source

Experimental Characterization of a New Piezoelectric Slit Valve and REMPI Spectroscopy of Cold, Chiral Indanol Molecules

, 2019
There is a constant need for new and better methods to identify, characterize and separate different substances. Especially important are chiral molecules, since they play a crucial role in medical research and drug development.
Langenhan, J.
core