Results 151 to 160 of about 42,748 (282)

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

open access: yesAngewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Synthesis and antagonistic activities of enantiomers of cyclic platelet-activating factor analogues.

open access: bronze, 1989
Hideki T. Miyazaki   +5 more
openalex   +2 more sources

Interfacing B‐DNA and DNA Mimic Foldamers

open access: yesAngewandte Chemie International Edition, EarlyView.
Helical aromatic oligoamide DNA mimic foldamers that reproduce the shape and charge distribution of duplex B‐DNA have been interfaced with DNA duplexes by means of a new linker that serves both as a DNA hairpin and as an aromatic oligoamide unit. In the resulting chimeric molecules, the linker does not perturb the DNA duplex structure and converts the ...
Manuel Loos   +10 more
wiley   +1 more source

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