Results 151 to 160 of about 107,976 (280)

Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism

Advanced Science, EarlyView.
Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Richard S. Edwards, Ella‐May Hards, Sofia N. dos Santos, Hannah E. Greenwood, Madeleine E. George, Andrea Emanuelli, Muhammet Tanc, Thomas R. Eykyn, Timothy H. Witney   +8 more
wiley   +1 more source

Multispectral Chiral Quasi‐Bound States in the Continuum Enabled Microfluidics for High‐Throughput Molecular Screening and Quantification

Advanced Science, EarlyView.
A microfluidics‐integrated chiral quasi‐BIC metachip is developed that generates strong broadband CD from 0.5–2.0 THz in aqueous environments. A UMAP algorithm processes the resulting multidimensional CD features for simultaneous biomolecular conformation identification and concentration quantification (0.05–0.3 mg dL−1).
Xinyue Liang, Zihan Zhao, Xiaocong Tang, Haiyue Yang, Lanju Liang, Meng Zhao, Cong Wang, Lei Wang, Xumin Ding   +8 more
wiley   +1 more source

Chirality of New Drug Approvals (2013–2022): Trends and Perspectives

Journal of Medicinal Chemistry
Many drugs are chiral with their chirality determining their biological interactions, safety, and efficacy. Since the 1980s, there has been a regulatory preference to bring single enantiomer to market.
Rebecca U McVicker, Niamh M. O’Boyle
semanticscholar   +1 more source

Luminescent Chiral Molecular Glasses by Melt‐Quenching Enantiopure BINAP

Advanced Science, EarlyView.
Melt‐quenching of enantiopure BINAP yields transparent chiral molecular glasses that retain axial chirality and display blue‐shifted luminescence together with strongly enhanced circularly polarized emission with dissymmetry factors |glum| of ≈10−2.
Nuttaporn Krittametaporn, Philipp Ralle, Dorothea Dierks, Christian Nelle, Suresh K. Vasa, Pascal Kolodzeiski, Rasmus Linser, Andreas Steffen, Sebastian Henke   +8 more
wiley   +1 more source

Metastasis to the F344 Rat Pancreas from Lung Cancer Induced by 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)- 1-butanol, Constituents of Tobacco Products [PDF]

, 2018
Ramesh C. Kovi, Charles S. Johnson, Silvia Balbo, Stephen S. Hecht, M. Gerard O’Sullivan   +4 more
openalex   +1 more source

Flexible Crystals, Polymorph Selection and Interface Engineering for Organic Electronics: How New Discoveries and Established Knowledge Can Provide New Stimuli for Research Into Organic Semiconducting Single Crystals

Advanced Electronic Materials, EarlyView.
This work reviews recent advances in Organic Semiconducting Single Crystals (OSSCs), focusing on mechanical flexibility for robust devices, polymorph control for precise phase selection, and interface engineering with self‐assembled monolayers to improve alignment and performance.
Alessando Fraleoni‐Morgera, Siddharth Joshi, Neal Hickey, Silvano Geremia   +3 more
wiley   +1 more source

Spin Matters: A Multidisciplinary Roadmap to Understanding Spin Effects in Oxygen Evolution Reaction During Water Electrolysis

Advanced Energy Materials, EarlyView.
This roadmap offers a forward‐looking perspective on spin enhancement in the oxygen evolution reaction. It highlights how combining systematic experiments, advanced computational modeling, and novel magnetic, chiral, or hybrid materials can deepen the understanding of spin‐dependent catalytic mechanisms.
Emma van der Minne, Priscila Vensaus, Vadim Ratovskii, Seenivasan Hariharan, Jan Behrends, Cesare Franchini, Jonas Fransson, Sarnjeet S. Dhesi, Felix Gunkel, Florian Gossing, Georgios Katsoukis, Ulrike I. Kramm, Magalí Lingenfelder, Qianqian Lan, Yury V. Kolen'ko, Yang Li, Ramsundar Rani Mohan, Jeffrey McCord, Lingmei Ni, Eva Pavarini, Rossitza Pentcheva, David H. Waldeck, Michael Verhage, Anke Yu, Zhichuan J. Xu, Piero Torelli, Silvia Mauri, Narcis Avarvari, Anja Bieberle‐Hütter, Christoph Baeumer   +29 more
wiley   +1 more source

The Combination of Chiral Assembly and Chiral Template Effects Boosts Circularly Polarized Luminescence of Perovskite Nanocrystals

Angewandte Chemie, EarlyView.
We show that the hierarchical order of perovskite nanocrystal assemblies formed within a nanostructured, chal liquid‐crystalline template exhibits extremely high circularly polarized luminescence (CPL). This is due to the helical arrangement of PNCs in the template voids and capitalizes on the inherent electrooptic properties of the template ...
Mateusz Pawlak, Julia Abramowicz, Nadesh Fiuza Maneiro, Gail A. Vinnacombe‐Willson, Sunghwan Jo, Elie Benchimol, Piotr Roszkowski, Zitao Chen, Da Wang, Guido H. Clever, Luis M. Liz‐Marzán, Agustín Mihi, Lakshminarayana Polavarapu, Wiktor Lewandowski   +13 more
wiley   +2 more sources

Symmetry Breaking in Chiral Gold Nanoclusters by Ansa‐Metallamacrocycles Strain

Aggregate, EarlyView.
In this work, we prepare a chiral Au11 nanocluster ligated by diphosphine ligand, Au11(dppp)5Cl3, which is induced by the unique ansa‐metallamacrocycle stain (the “Au─P─CH2CH2CH2─P─Au” staple). ABSTRACT Chiral nanomaterials have recently stimulated significant interest in both fundamental research and practical applications (e.g., nanoprobes for ...
Zhiwen Li, Jingjing Zhang, Zhaoxian Qin, Huan Li, Zhaohui Tong, José A. Gascón, Gao Li   +6 more
wiley   +1 more source

Bright Circularly Polarized Electrochemiluminescence from Heterobinuclear IrIII–AuI Enantiomers

Angewandte Chemie, EarlyView.
Efficient and bright circularly polarized electrochemiluminescence (CP‐ECL) is achieved in a class of enantiopure hetobinuclear iridium(III)–gold(I) complexes owing to the combination of high ECL efficiency with stability, good emission dissymmetry factor and high brightness, thus paving the way to the next‐generation of bright CP‐ECL probes.
Lavinia Ballerini, Miaoxia Liu, Lorenzo Arrico, Silvia Voci, Christophe Gourlaouen, Chantal Daniel, Vincent César, Stéphane Bellemin‐Laponnaz, Francesco Zinna, Laurent Bouffier, Federico Polo, Lorenzo Di Bari, Neso Sojic, Matteo Mauro   +13 more
wiley   +2 more sources