Results 11 to 20 of about 88,128 (341)
Biomolecules, 2022 Beta-hydroxybutyrate (βOHB), along with acetoacetate and acetone, are liver-produced ketone bodies that are increased after fasting or prolonged exercise as an alternative fuel source to glucose. βOHB, as the main circulating ketone body, is not only a G-
Matthew L. Klos +7 more
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An electronic circular dichroism spectroscopy method for the quantification of L- and D-amino acids in enantiomeric mixtures [PDF]
Royal Society Open Science, 2021 Rapid quantitative analysis of single chiral amino acid (aa) was achieved using circular dichroism (CD) with data analysis by standard calibration curve.
Ruiwen Ding, Jianxi Ying, Yufen Zhao
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BCL::EMAS — Enantioselective Molecular Asymmetry Descriptor for 3D-QSAR
Molecules, 2012 Stereochemistry is an important determinant of a molecule’s biological activity. Stereoisomers can have different degrees of efficacy or even opposing effects when interacting with a target protein.
Mariusz Butkiewicz +3 more
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Lipase Assisted (S)-Ketoprofen Resolution from Commercially Available Racemic Mixture
Pharmaceuticals, 2021 Ketoprofen is a commercially available drug sold as a racemic mixture that belongs to the family of non-steroidal anti-inflammatory drugs known as profens.
Daniela Estrada-Valenzuela +5 more
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Dexibuprofen Therapeutic Advances: Prodrugs and Nanotechnological Formulations
Pharmaceutics, 2021 S-(+) enantiomer of ibuprofen (IBU) dexibuprofen (DXI) is known to be more potent than its R-(−) form and exhibits many advantages over the racemic mixture of IBU such as lower toxicity, greater clinical efficacy, and lesser variability in therapeutic ...
Anna Gliszczyńska +1 more
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Enantiomeric oxidation of organic sulfides by the filamentous fungi Botrytis cinerea, Eutypa lata and Trichoderma viride [PDF]
, 2007 The biotransformations of a series of substituted sulfides were carried out with the filamentous fungi Botrytis cinerea, Eutypa lata and Trichoderma viride.
Annunziata +28 more
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, 2021 Only in exceptional cases, a pair of enantiomers do form a series of mixed crystals. The most well-known of the exceptions is the system laevorotatory carvoxime+dextrorotatory carvoxime; its properties are discussed in some detail. Also, attention is given to recent work on the polymorphism of optically active drugs.
Oonk, H. A. J., Rietveld, I. B.
openaire +1 more source
Binding and transport of D-aspartate by the glutamate transporter homolog GltTk
eLife, 2019 Mammalian glutamate transporters are crucial players in neuronal communication as they perform neurotransmitter reuptake from the synaptic cleft. Besides L-glutamate and L-aspartate, they also recognize D-aspartate, which might participate in mammalian ...
Valentina Arkhipova +5 more
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Field-induced diastereomers for chiral separation [PDF]
, 2019 A novel approach for the state-specific enantiomeric enrichment and the spatial separation of enantiomers is presented. Our scheme utilizes techniques from strong-field laser physics, specifically an optical centrifuge in conjunction with a static ...
Küpper, Jochen +4 more
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Biocatalytic Route to Chiral Precursors of β-Substituted-γ-Amino Acids [PDF]
, 2011 In this work, we utilized commercial lipases (from Thermomyces lanuginosa, Rhizopus delemar, and Mucor miehei) as biocatalysts for the efficient synthesis of precursors of β-substituted-γ-amino acids.
Martinez, Carlos A., Mukherjee, Herschel
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