Results 11 to 20 of about 42,748 (282)
Only in exceptional cases, a pair of enantiomers do form a series of mixed crystals. The most well-known of the exceptions is the system laevorotatory carvoxime+dextrorotatory carvoxime; its properties are discussed in some detail. Also, attention is given to recent work on the polymorphism of optically active drugs.
Oonk, H. A. J., Rietveld, I. B.
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The crystal structure of (R,R)-4-bromo-2-{4-[4-bromo-1-(4-toluenesulfonyl)-1H-pyrrol-2-yl]-1,3-dinitrobutan-2-yl}-1-(4-toluenesulfonyl)-1H-pyrrole (1, C26H24Br2N4O8S2) is presented. The title compound was isolated in suitable yield as a by-product in our
Harry C. Sample+2 more
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BCL::EMAS — Enantioselective Molecular Asymmetry Descriptor for 3D-QSAR
Stereochemistry is an important determinant of a molecule’s biological activity. Stereoisomers can have different degrees of efficacy or even opposing effects when interacting with a target protein.
Mariusz Butkiewicz+3 more
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Determination of the L- and D-amino acid composition in proteins is important for monitoring process-induced racemization, and thereby protein quality loss, in food and feed. Such analysis has so far been challenging due to the need for sample hydrolysis,
Marianne Danielsen+2 more
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Multiphase bioreactors using interfacial biocatalysts are unique tools in life sciences such as pharmaceutical and biotechnology. In such systems, the formation of microdroplets promotes the mass transfer of reagents between two different phases, and the
Emma Piacentini+2 more
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Binding and transport of D-aspartate by the glutamate transporter homolog GltTk
Mammalian glutamate transporters are crucial players in neuronal communication as they perform neurotransmitter reuptake from the synaptic cleft. Besides L-glutamate and L-aspartate, they also recognize D-aspartate, which might participate in mammalian ...
Valentina Arkhipova+5 more
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The enantiomers of many chiral drugs not only exhibit different pharmacological effects in regard to targets that dictate therapeutic and toxic effects, but are also handled differently in the body due to pharmacokinetic effects.
Grant C Churchill+3 more
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A stereo-selective growth inhibition profile of ginsenoside Rh2 on human colon cancer cells
We compared the stereo-selective growth inhibition effects of purified enantiomeric pairs of ginsenoside Rh2 (20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2) on human colon cancer cells in vitro with non-invasive real-time cellular analysis. When 50 μM,
Yunju Jeong+3 more
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ChemInform Abstract: Processes to Separate Enantiomers [PDF]
AbstractReview: [enantioselective crystallization, preparative chromatography or a combination of both processes; 315 refs.
Andreas Seidel-Morgenstern+2 more
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AR-15512 (formerly known as AVX-012 and WS-12) is a TRPM8 receptor agonist currently in phase 2b clinical trials for the treatment of dry eye. This bioactive compound with menthol-like cooling activity has three stereogenic centers, and its final ...
Sergio Rodríguez-Arévalo+5 more
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