Results 11 to 20 of about 42,748 (282)

Enantiomers

, 2021
Only in exceptional cases, a pair of enantiomers do form a series of mixed crystals. The most well-known of the exceptions is the system laevorotatory carvoxime+dextrorotatory carvoxime; its properties are discussed in some detail. Also, attention is given to recent work on the polymorphism of optically active drugs.
Oonk, H. A. J., Rietveld, I. B.
openaire   +1 more source

Structure of (R,R)-4-bromo-2-{4-[4-bromo-1-(4-toluenesulfonyl)-1H-pyrrol-2-yl]-1,3-dinitrobutan-2-yl}-1-(4-toluenesulfonyl)-1H-pyrrole, another ostensible by-product in the synthesis of geminal-dimethyl hydrodipyrrins

Acta Crystallographica Section E: Crystallographic Communications, 2023
The crystal structure of (R,R)-4-bromo-2-{4-[4-bromo-1-(4-toluenesulfonyl)-1H-pyrrol-2-yl]-1,3-dinitrobutan-2-yl}-1-(4-toluenesulfonyl)-1H-pyrrole (1, C26H24Br2N4O8S2) is presented. The title compound was isolated in suitable yield as a by-product in our
Harry C. Sample, Brendan Twamley, Mathias O. Senge   +2 more
doaj   +1 more source

BCL::EMAS — Enantioselective Molecular Asymmetry Descriptor for 3D-QSAR

Molecules, 2012
Stereochemistry is an important determinant of a molecule’s biological activity. Stereoisomers can have different degrees of efficacy or even opposing effects when interacting with a target protein.
Mariusz Butkiewicz, Jens Meiler, Edward W. Lowe, Gregory Sliwoski   +3 more
doaj   +1 more source

Simultaneous Determination of L- and D-Amino Acids in Proteins: A Sensitive Method Using Hydrolysis in Deuterated Acid and Liquid Chromatography–Tandem Mass Spectrometry Analysis

Foods, 2020
Determination of the L- and D-amino acid composition in proteins is important for monitoring process-induced racemization, and thereby protein quality loss, in food and feed. Such analysis has so far been challenging due to the need for sample hydrolysis,
Marianne Danielsen, Caroline Nebel, Trine Kastrup Dalsgaard   +2 more
doaj   +1 more source

Comparison between Lipase Performance Distributed at the O/W Interface by Membrane Emulsification and by Mechanical Stirring

Membranes, 2021
Multiphase bioreactors using interfacial biocatalysts are unique tools in life sciences such as pharmaceutical and biotechnology. In such systems, the formation of microdroplets promotes the mass transfer of reagents between two different phases, and the
Emma Piacentini, Rosalinda Mazzei, Lidietta Giorno   +2 more
doaj   +1 more source

Binding and transport of D-aspartate by the glutamate transporter homolog GltTk

eLife, 2019
Mammalian glutamate transporters are crucial players in neuronal communication as they perform neurotransmitter reuptake from the synaptic cleft. Besides L-glutamate and L-aspartate, they also recognize D-aspartate, which might participate in mammalian ...
Valentina Arkhipova, Gianluca Trinco, Thijs W Ettema, Sonja Jensen, Dirk J Slotboom, Albert Guskov   +5 more
doaj   +1 more source

Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance.

PLoS ONE, 2020
The enantiomers of many chiral drugs not only exhibit different pharmacological effects in regard to targets that dictate therapeutic and toxic effects, but are also handled differently in the body due to pharmacokinetic effects.
Grant C Churchill, Michael Strupp, Antony Galione, Frances M Platt   +3 more
doaj   +1 more source

A stereo-selective growth inhibition profile of ginsenoside Rh2 on human colon cancer cells

CyTA - Journal of Food, 2019
We compared the stereo-selective growth inhibition effects of purified enantiomeric pairs of ginsenoside Rh2 (20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2) on human colon cancer cells in vitro with non-invasive real-time cellular analysis. When 50 μM,
Yunju Jeong, Seockmo Ku, Hyun Ju You, Geun Eog Ji   +3 more
doaj   +1 more source

ChemInform Abstract: Processes to Separate Enantiomers [PDF]

ChemInform, 2014
AbstractReview: [enantioselective crystallization, preparative chromatography or a combination of both processes; 315 refs.
Andreas Seidel-Morgenstern, Andreas Seidel-Morgenstern, Heike Lorenz   +2 more
openaire   +4 more sources

Synthesis, Characterization and HPLC Analysis of the (1S,2S,5R)-Diastereomer and the Enantiomer of the Clinical Candidate AR-15512

Molecules, 2021
AR-15512 (formerly known as AVX-012 and WS-12) is a TRPM8 receptor agonist currently in phase 2b clinical trials for the treatment of dry eye. This bioactive compound with menthol-like cooling activity has three stereogenic centers, and its final ...
Sergio Rodríguez-Arévalo, Eugènia Pujol, Sònia Abás, Carles Galdeano, Carmen Escolano, Santiago Vázquez   +5 more
doaj   +1 more source