Results 191 to 200 of about 107,976 (280)

Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders

Angewandte Chemie, EarlyView.
The combination of bicyclic monoterpene‐ and pyrrolidine‐alkaloid fragments yields novel pseudo‐natural products. Biological characterization revealed that these iDegs are inhibitors and degraders of indoleamine‐2,3‐dioxygenase. Abstract Terpenoid alkaloids are derived from the fusion of structurally diverse terpenoid‐ and alkaloid moieties.
Xiu‐Fen Cheng, Belén Lucas, Philipp Lampe, Stefano Ugel, Suyuan Chen, Anke Unger, Matthias Bischoff, Soheila Rezaei Adariani, Kesava Reddy Naredla, Kamal Kumar, Annika Schmidt, Carsten Strohmann, Petra Janning, Raphael Gasper, María Lucas, Malte Gersch, Sonja Sievers, Vincenzo Bronte, Slava Ziegler, Herbert Waldmann   +19 more
wiley   +2 more sources

Enantioconvergent Access to Chiral S(VI) Stereocenters by Kinetic Resolution of Sulfonimidoyl Chlorides

Angewandte Chemie, EarlyView.
An enantioconvergent approach for the kinetic resolution of S(VI) stereocenters that leverages the electrophilic reactivity of the chiral sulfur atom is described. The catalytic process provides access to sulfonimidoyl chlorides and sulfonimidates, which are among the least studied S(VI) functionalities.
Arko Das, Shree Krishna Dhakal, Ramon Trevino, Seth O. Fremin, Vy T. B. Nguyen, Arka Porey, Sachchida Nand, Chandan Kumar Giri, Daniel J. Wherritt, Hadi D. Arman, Oleg V. Larionov   +10 more
wiley   +2 more sources

Direct Separation and Determination of Synephrine Enantiomers by High-Performance Liquid Chromatography with Electrochemical Detection.

, 1995
Fumiyo Kusu, Katsumi MATSUMOTO, Kiyoko Takamura   +2 more
openalex   +2 more sources

Untersuchungen zum Ursprung der Substratspezifität von Enzymen der Amidohydrolase‐Superfamilie

Angewandte Chemie, EarlyView.
Umfassende Analysen zweier Enzymklassen aus der Amidohydrolase‐Superfamilie (AHS) ergaben, dass die Katalyse über eine 1,4‐ bzw. 1,6‐nukleophile konjugierte Addition abläuft und diese Eigenschaft die Substratspezifität bestimmt. Obwohl alle Substrate und Produkte vollständig achiral sind, führt dieser mechanistische Unterschied zu einer invertierten ...
Lukas Drexler, Torben F. Fürtges, Till Rudack, Reinhard Sterner   +3 more
wiley   +1 more source

Stereoselective high-performance liquid chromatography and capillary electrophoresis analysis and in vitro study of the serum protein binding of carvedilol enantiomers

, 2009
Lilian Clohs
openalex   +1 more source

Suppression of Oligomer Formation and Formation of Non-Toxic Fibrils upon Addition of Mirror-Image Aβ42 to the Natural l-Enantiomer.

Angewandte Chemie, 2017
S. Dutta, Alejandro R. Foley, C. J. Warner, Xiaolin Zhang, M. Rolandi, B. Abrams, Jevgenij A. Raskatov   +6 more
semanticscholar   +1 more source

Enantiomer Adsorption in an Applied Magnetic Field: D‐ and L‐Aspartic Acid on Ni(100)

, 2022
Michael Radetic, Andrew J. Gellman
openalex   +1 more source

Separation of the Two Enantiomers of Naproxcinod by Chiral Normal-Phase Liquid Chromatography [PDF]

, 2011
Kai Zhang, Z. Yuan, Li Li, Xiaowei Shi, Liang Cao, Yu Du, Ning Xue   +6 more
openalex   +1 more source

Fluoride‐Transfer Asymmetric Allylic Alkylation Enables Regiodivergent, Stereoselective Cross‐Electrophile Coupling

Angewandte Chemie, EarlyView.
We report a fluoride‐transfer asymmetric allylic alkylation (AAA) in which all reagent atoms, including the leaving group, are incorporated into the products. This atom‐efficient AAA protocol enables the cross‐electrophile coupling of allyl fluorides and gem‐difluoroalkenes, providing a catalyst‐controlled, regiodivergent, and stereoselective access to
Jordi Duran, Vyali Georgian Moldoveanu, Claudia Barroso, Geraldo Augusto Pereira, Bart Limburg, Xavier Companyó   +5 more
wiley   +2 more sources

Experimental and theoretical study on chiral recognition mechanism of ketoconazole enantiomers using heptakis (2,3,6-tri-O-methyl)-β-cyclodextrin

, 2014
Wan Aini Wan Ibrahim, Siti Rosilah Arsad, Hasmerya Maarof, Mohd Marsin Sanagi   +3 more
openalex   +2 more sources