Results 211 to 220 of about 107,976 (280)
Capillary Electrophoresis Separation of the Six Pairs of Chiral Pharmaceuticals Enantiomers
, 2013 Hai Xue, Yukai Jiao, Hongyi Li
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Angewandte Chemie International Edition, EarlyView.The N‐methyltransferase SgPsmC was characterised and applied in the kinetic resolution (KR) of easily obtainable pyrroloindolines. Substitution at 3a‐position proved to be a principal determinant for the enzyme's enantioselectivity. While moving toward laboratory scale, the reaction was coupled with a methionine adenosyl transferase for in situ ...
Benjamin Panagiotis Chapple +7 more
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Pharmacodynamics and pharmacokinetics of ketoprofen enantiomers in sheep [PDF]
, 2001 Abdul K. Arifah +3 more
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Angewandte Chemie International Edition, EarlyView.Six bacterial terpene synthases are reported, one of which produces instable chitinosphaerol, which is spontaneously transformed into several known natural products requiring structural revision. A second enzyme yields thermally labile neodolabella‐1(14),2,7‐triene, which upon heating shows sequential conversion into thermocyclenes A–C.
Heng Li +4 more
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Isolation and Characterization of S-Enantiomer in Montelukast
, 2013 Vijaya Lakshmi Maddala +4 more
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On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily
Angewandte Chemie International Edition, EarlyView.Comprehensive analyses of two enzyme classes from the amidohydrolase superfamily (AHS) revealed that catalysis proceeds either via 1,4 or 1,6 nucleophilic conjugate addition and that this property defines substrate specificity. Moreover, although all substrates and products are entirely achiral, this mechanistic difference results in an inverted ...
Lukas Drexler +3 more
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