Results 221 to 230 of about 42,748 (282)

Clade III Synthases Add Cyclic and Linear Terpenoids to the Psilocybe Metabolome

ChemBioChem, EarlyView.
The Psilocybe cubensis terpene synthases, CubB‐CubE, were investigated. Product formation assays identified CubB as a (3R,6E)‐(‐)‐nerolidol or linalool synthase, whereas CubC is a multiproduct synthase catalyzing the formation of β‐caryophyllene and other linear and cyclic sesquiterpenes/‐terpenoids.
Nick Zschoche, Sebastian Schober, Karl Walther, Andrew R. Chadeayne, Markus Gressler, Stefan Bartram, Sarah E. O’Connor, Dirk Hoffmeister   +7 more
wiley   +1 more source

Physiologically-Based Biopharmaceutics Modeling for Ibuprofen: Identifying Key Formulation Parameter and Virtual Bioequivalence Assessment. [PDF]

Pharmaceutics
Zarzoso-Foj J, Cuquerella-Gilabert M, Merino-Sanjuan M, Reig-Lopez J, Mangas-Sanjuán V, Garcia-Arieta A.   +5 more
europepmc   +1 more source

Diversity of ThDP‐Dependent Enzymes Forming Chiral Tertiary Alcohols

ChemBioChem, EarlyView.
Chiral tertiary alcohols are widespread in nature and bioactive compounds; however, their asymmetric synthesis faces several challenges. This review outlines the toolbox of ThDP‐dependent enzymes able to produce tertiary alcohols through the formation of CC bond formation using ketones as acceptor substrates. Herein, the substrate scope, the diversity
Daniela Bjarnesen, Lucrezia Lanza, Francesco Presini, Pier Paolo Giovannini, Michael Müller   +4 more
wiley   +1 more source

Determination of the Enantiomerization Barrier of Midazolam in Aqueous Conditions by Electronic Circular Dichroism and Dynamic Enantioselective HPLC/UHPLC. [PDF]

Molecules
Mammone FR, Sadutto D, Antoniella E, Pierini M, Cirilli R.   +4 more
europepmc   +1 more source

Mammalian Tolerance to Amino Acid Heterochirality

ChemBioChem, EarlyView.
Organisms preferentially use l‐amino acids (l‐AAs). However, de novo synthesized l‐AAs are in part converted to d‐AAs. The ribosome has a robust system to use l‐AAs for protein synthesis, whereas non‐ribosomal synthesis can also use d‐AAs. Furthermore, some AA residues can be post‐translationally isomerized through enzymatic or spontaneous processes ...
Sakiko Taniguchi, Kenichiro Adachi, Xuan Tran, Masataka Suzuki, Jumpei Sasabe   +4 more
wiley   +1 more source

Calculation of Vibrational Circular Dichroism Spectra Employing Nuclear Velocity Perturbation or Magnetic Field Perturbation Theory Using an Atomic-Orbital-Based Linear Response Approach. [PDF]

J Phys Chem A
Kumar R, Luber S.
europepmc   +1 more source

Genome Mining Reveals a Novel Nephthenol‐Producing Diterpene Synthase from the Sandfly Lutzomyia Longipalpis

ChemBioChem, EarlyView.
The discovery of a terpene synthase of insect origin that makes the apparently cryptic product nephthenol from geranylgeranyl diphosphate sheds light on hidden biosynthetic potential. Populations of the sandfly, Lutzomyia longipalpis, use the diterpene sobralene as a sex/aggregation pheromone, which is likely produced in the insect through the activity
Charles Ducker, Catherine McKeown, Igor F. P. Da Silva, Isis Torres Souza, John A. Pickett, Antônio E. G. Santana, Neil J. Oldham   +6 more
wiley   +1 more source

Developing a Chromatographic Method for Quantifying Latanoprost and Related Substances in Glaucoma Treatments. [PDF]

Pharmaceuticals (Basel)
Asendrych-Wicik K, Malik K, Markowicz-Piasecka M.   +2 more
europepmc   +1 more source

Development of Multipurpose Supported Asymmetric Salen Catalysts by Cu(0)‐Mediated Reversible Deactivation Radical Copolymerization

ChemCatChem, EarlyView.
The challenge of recycling heterogeneous catalysts and reusing them in different reactions was addressed. To this end, salen complexes were anchored on methacrylate insoluble polymers obtained using the Cu(0)‐mediated RDRP method. Their reactivity and recyclability were analyzed in asymmetric ring opening and dynamic kinetic resolution of epoxides ...
Rafaela Bechara, Mohamed Mellah, Nadine Barroca‐Aubry, François Ozanam, Anne‐Chantal Gouget‐Laemmel, Damien Aureau, Diana Dragoé, Philippe Roger, Emmanuelle Schulz   +8 more
wiley   +1 more source

The continuing significance of chiral agrochemicals. [PDF]

Pest Manag Sci
Jeschke P.
europepmc   +1 more source