Merging Peptide and Enzyme Catalysis in a Single Protein Domain Bearing Two Separated Active Sites
ChemCatChem, EarlyView.A dual‐functional catalyst that unites peptide catalysis and biocatalysis within a single protein scaffold at two distinct active sites offers a promising strategy for cascade catalysis. This hybrid catalyst enabled here a one‐pot transformation of alcohols to C─C coupled products via enamine activation, revealing challenges such as mismatched reaction
Mathias Pickl +7 more
wiley +1 more source
Easy ROMP of Quinine Derivatives Toward Novel Chiral Polymers That Discriminate Mandelic Acid Enantiomers. [PDF]
Polymers (Basel)Majchrzak M +4 more
europepmc +1 more source
Advances in Ligand‐Driven Pd‐Catalyzed C─H Functionalizations: Recent Insights and Updates
ChemCatChem, EarlyView.The most significant advances in ligand‐driven Pd‐catalyzed organic synthesis over the past two years are presented. Processes involving C─H activation of substrates, avoiding their prefunctionalization are illustrated. Both the activity and selectivity of the catalyst depend on the design of the ligands (pyridones, pyridines, amino acids, phosphines ...
Jesús Moradell +3 more
wiley +1 more source
Chiral Growth of Gold Horns on Polyhedrons for SERS Identification of Enantiomers and Polarized Light-Induced Photothermal Sterilization. [PDF]
Materials (Basel)Shang B, Guan G.
europepmc +1 more source
ChemistryEurope, EarlyView.The first report on zinc‐catalyzed enantioselective alkylation of aldehydes mediated by a chiral auxiliary is revisited, and the studies show much more complex behavior than previously thought. Studies show an enantiodivergence of the reaction as a function of its progress, due to an autoinduction phenomenon.
Joseph El Khoury +3 more
wiley +1 more source
Enantioseparation of Mirabegron Using Cyclodextrin-based Chiral Columns: High-performance Liquid Chromatography and Molecular Modeling Study. [PDF]
J Sep SciMhammad A +5 more
europepmc +1 more source
Chemistry – A European Journal, EarlyView.A novel family of water‐soluble, nontoxic, and phosphorescent N‐glycosylated Ru(II) phenanthroline‐based complexes are reported. They exhibit photoselectivity indexes ranging from 10 to 44 in PC‐3 cells, while impacting cell migration and resistance to detachment after irradiation with blue light.
Elena de la Torre‐Rubio +5 more
wiley +1 more source
Screening of metallohelices for enantioselective targeting SARS-CoV-2 RNA G-quadruplex. [PDF]
Nucleic Acids ResSun Y +11 more
europepmc +1 more source
Chemistry – A European Journal, EarlyView.We employed a systematic quantum chemistry‐based computational approach for simulating chiral HPLC, incorporating high‐level DFT methods. For the popular polysaccharide‐based CSPs, 90%$\%$ of determined elution orders were computed correctly. Abstract We assess the capability of modern quantum chemical methods to simulate enantioseparation on chiral ...
Linda Nelles‐Ziegler +2 more
wiley +1 more source
Integrating Catalysis and Analysis: Accelerated Asymmetric Reaction Development With a Multitasking Reactivity Umpolung/Chiroptical Reporter Auxiliary. [PDF]
ChemistryKariapper FS, Bouda M, Wolf C.
europepmc +1 more source