Results 261 to 270 of about 42,748 (282)

The pharmacokinetics of the enantiomers of atenolol

Clinical Pharmacology and Therapeutics, 1989
A number of studies have demonstrated that lipophilic beta-adrenoceptor blocking agents, eliminated almost exclusively by hepatic metabolism, are stereoselectively metabolized in human beings. Previous studies in our laboratory have demonstrated that pindolol, a beta-adrenoceptor blocking agent of intermediate lipophilicity that is eliminated by both ...
Rebecca A Boyd, Kathleen M. Giacomini, Oluta Don-Pedro, Shu K Chin, Roger L. Williams   +4 more
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Stochastic Detection of Enantiomers

Journal of the American Chemical Society, 2006
The rapid quantification of the enantiomers of small chiral molecules is very important, notably in pharmacology. Here, we show that the enantiomers of drug molecules can be distinguished by stochastic sensing, a single-molecule detection technique.
Xiaofeng Kang, Stephen Cheley, Xiyun Guan, Hagan Bayley   +3 more
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CHROMATOGRAPHIC RESOLUTION OF ENANTIOMERS

Chemical Engineering Communications, 1998
Abstract In the pharmaceutical industry, the increasing demand of new single enantiomer products has raised a great interest towards chromatographic separation methods. While analytical applications of high performance liquid chromatography and gas chromatography are well established, the scaling up to preparative applications still needs a better ...
MAZZOTTI, MARCO GIUSEPPE, STORTI, GIUSEPPE, GELOSA, DAVINO, Lorenzetti, L., PEDEFERRI, MARIAPIA, MORBIDELLI, MASSIMO   +5 more
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Enantiomer specific pharmacokinetics

Pharmacology & Therapeutics, 1990
To indicate the extent of differences in the pharmacokinetics of enantiomers with respect to absorption and disposition phenomena. To emphasise the potential benefits of studying enantiospecific pharmacokinetics, that is, kinetics based on the measurement of the time-course of separate isomers rather than of the total, racemic drug ...
M.S. Lennard, G.T. Tucker
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Sympathomimetic enantiomers and asthma

Chirality, 1998
Airways of asthma patients can become hyperresponsive to airway spasmogens following regular use of isoprenaline or beta 2-selective sympathomimetics. Hyper-reactivity that results from acute exposure of animals to these drugs is pre-empted by vagal section (a procedure which does not influence spasmolytic efficacy of sympathomimetics), is not ...
Dean A. Handley, John Morley, J. R. McCullough, S. D. Crowther   +3 more
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Ketamine enantiomers and acetylcholinesterase

Biochemical Pharmacology, 1991
(-)-ketamine was found to be more potent than (+)-ketamine in all the studied reactions with acetylcholinesterase. In most cases the difference was small but for two rate constants the (-)-form was unique in having effects. Thus, the stereoselectivity of ketamine in this system is the opposite of most other systems studied.
Mona L. Koch, Elisabet Artursson, Gertrud Puu   +2 more
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Selective radiolysis of enantiomers

Radiation and Environmental Biophysics, 1976
The gamma-induced decarboxylation of beta-phenylalanine in the solid state is a chain reaction. Both enantiomers and the racemate of beta-phenylalanine-1-14C show different exponential dose-effect curves for the radiation-induced cleavage of 14CO2.
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Enantiomers in arthritic disorders

Pharmacology & Therapeutics, 1990
Drugs which have a center of asymmetry are often administered as an equal mixture of the two possible enantiomeric forms i.e. a racemate. However, there are frequently large pharmacodynamic and pharmacokinetic differences between enantiomers. Consequently, it is possible that while one enantiomer mediates the antiinflammatory or antirheumatic action ...
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Kinetics of misonidazole enantiomers

Clinical Pharmacology and Therapeutics, 1984
The kinetics of misonidazole enantiomers were followed in nine healthy subjects after a single oral dose of racemic misonidazole (1.0 gm/m2). Mean clearance of (+)-misonidazole was 14% greater than that for (-)-misonidazole and mean volume of distribution was slightly greater (3%) for the (+)-enantiomer.
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Ifosfamide enantiomers: pharmacokinetics in children

Cancer Chemotherapy and Pharmacology, 1994
Ifosfamide, like other oxazaphosphorine drugs, is chiral and there is some evidence, mainly from animal studies, of stereo-selective differences in metabolism, excretion and cytotoxic activity between the two enantiomers. The pharmacokinetics of racemic ifosfamide (RAC-IFO), R-ifosfamide (R-IFO) and S-ifosfamide (S-IFO) were studied in five children ...
Prasad, V. K., Corlett, S. A., Abaasi, K., Heney, D., Lewis, I., Chrystyn, H.   +5 more
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