Results 291 to 300 of about 88,128 (341)

Chromatographic separation of enantiomers

Pharmaceutisch Weekblad Scientific Edition, 1988
In this paper a review is presented on the chromatographic analysis of enantiomers with special attention to high pressure liquid chromatography. Also, some examples of resolution of racemates by thin layer chromatography and gas chromatography are given.
K G, Feitsma, B F, Drenth
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The Enantiomer of Cholesterol

The Journal of Membrane Biology, 2004
Cholesterol plays a variety of significant roles in biological systems. However, the mechanisms by which cholesterol functions remain largely unclear. The enantiomer of cholesterol (ent-cholesterol)--which has identical physical properties, but opposite three-dimensional configuration compared to cholesterol--is a unique tool that can be used to better
E J, Westover, D F, Covey
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Stochastic Detection of Enantiomers

Journal of the American Chemical Society, 2006
The rapid quantification of the enantiomers of small chiral molecules is very important, notably in pharmacology. Here, we show that the enantiomers of drug molecules can be distinguished by stochastic sensing, a single-molecule detection technique.
Xiao-Feng, Kang, Stephen, Cheley, Xiyun, Guan, Hagan, Bayley   +3 more
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Biotransformation of deprenyl enantiomers

European Journal of Drug Metabolism and Pharmacokinetics, 1999
Rats were treated with either (-)- or (+)-deprenyl, and the metabolites extracted from the plasma, liver, kidney and heart homogenates were studied by chiral capillary electrophoresis (CE). Stereoselective dealkylation of both optical isomers with the formation of desmethyldeprenyl (DD), methamphetamine (MA), and amphetamine (A) was found.
E, Szökö, H, Kalász, K, Magyar
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Ketamine enantiomers and acetylcholinesterase

Biochemical Pharmacology, 1991
(-)-ketamine was found to be more potent than (+)-ketamine in all the studied reactions with acetylcholinesterase. In most cases the difference was small but for two rate constants the (-)-form was unique in having effects. Thus, the stereoselectivity of ketamine in this system is the opposite of most other systems studied.
G, Puu, M, Koch, E, Artursson
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Sympathomimetic enantiomers and asthma

Chirality, 1998
Airways of asthma patients can become hyperresponsive to airway spasmogens following regular use of isoprenaline or beta 2-selective sympathomimetics. Hyper-reactivity that results from acute exposure of animals to these drugs is pre-empted by vagal section (a procedure which does not influence spasmolytic efficacy of sympathomimetics), is not ...
D A, Handley, J R, McCullough, S D, Crowther, J, Morley   +3 more
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CHROMATOGRAPHIC RESOLUTION OF ENANTIOMERS

Chemical Engineering Communications, 1998
Abstract In the pharmaceutical industry, the increasing demand of new single enantiomer products has raised a great interest towards chromatographic separation methods. While analytical applications of high performance liquid chromatography and gas chromatography are well established, the scaling up to preparative applications still needs a better ...
MAZZOTTI, MARCO GIUSEPPE, STORTI, GIUSEPPE, GELOSA, DAVINO, Lorenzetti, L., PEDEFERRI, MARIAPIA, MORBIDELLI, MASSIMO   +5 more
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Resolution of aristeromycin enantiomers

Journal of Medicinal Chemistry, 1985
L'activite biologique des analogues carbocycliques de l'adenosine et de l'adenosine monophosphate peut etre attribuee exclusivement a la presence de l'enantiomere(−) dans les melanges ...
P, Herdewijn, J, Balzarini, E, De Clercq, H, Vanderhaeghe   +3 more
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Spin crossover properties of enantiomers, co-enantiomers, racemates, and co-racemates

Dalton Transactions, 2016
Spin-crossover Puzzle: SCO co-enantiomers, racemates, and co-racemates were successfully assembled via cocrystallization of four prefabricated enantiomeric iron(ii) modules 4R, 4S, 5R and 5S.
Long-Fang, Qin, Chun-Yan, Pang, Wang-Kang, Han, Feng-Li, Zhang, Lei, Tian, Zhi-Guo, Gu, Xuehong, Ren, Zaijun, Li   +7 more
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Crystallization of enantiomers

Chemical Engineering and Processing: Process Intensification, 2006
Abstract Pure enantiomers are of large interest for several industries. Chemical synthesis is frequently not selective and provides racemic mixtures causing a large interest in efficient separation processes. Preparative chromatography is nowadays a powerful and flexible but expensive technology.
Lorenz, H., Perlberg, A., Sapoundjiev, D., Elsner, M., Seidel-Morgenstern, A.   +4 more
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