Results 31 to 40 of about 107,976 (280)

Structure and mechanism of acetolactate decarboxylase [PDF]

, 2013
Acetolactate decarboxylase catalyzes the conversion of both enantiomers of acetolactate to the (R)-enantiomer of acetoin, via a mechanism that has been shown to involve a prior rearrangement of the non-natural (R)-enantiomer substrate to the natural (S ...
Anand R., Chan K. K., Collaborative Computational Project Number 4, Crout D. H. G., Crout D. H. G., Crout D. H. G., Crout D. H. G., Crout D. H. G., Dean Rea, DeLano W. L., Dolin M. I., Drake A. F., Dulieu C., Fisher Z., Fusetti F., Gerlt J. A., Hall D. R., Hill R. K., Ho M.-C., Jones T. A., Kabsch W., Løken J. P, Martin Wills, Moen A. R., Murshudov G. N., Najmudin S., Okrasa K., Perrakis A., Read R. J., Robins D. J., Shabir Najmudin, Stritzke K., Størmer F. C., Victoria A. Marlow, Vilmos Fülöp, Vinogradov M., Yan Y.   +36 more
core   +1 more source

The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy

Frontiers in Pharmacology, 2022
In an ex vivo rat ocular hypertension (OHT) model, the neurosteroid allopregnanolone (AlloP) exerts neuroprotective effects via enhancement of both GABAA receptors and autophagy.
Makoto Ishikawa, Makoto Ishikawa, Toru Nakazawa, Toru Nakazawa, Toru Nakazawa, Toru Nakazawa, Hiroshi Kunikata, Hiroshi Kunikata, Kota Sato, Kota Sato, Takeshi Yoshitomi, Takeshi Yoshitomi, Kathiresan Krishnan, Douglas F. Covey, Douglas F. Covey, Douglas F. Covey, Douglas F. Covey, Charles F. Zorumski, Charles F. Zorumski, Charles F. Zorumski, Yukitoshi Izumi, Yukitoshi Izumi, Yukitoshi Izumi   +22 more
doaj   +1 more source

Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography [PDF]

, 2017
By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ(9)-THC in medicinal marijuana (Bedrocan®).
Cavazzini, A, D'Acquarica, I, Gasparrini, F., Ismail, O, Manzo, C, Mazzoccanti, G, Villani, C, Wilcox, M   +7 more
core   +2 more sources

A Validated Chiral LC–MS/MS Method for the Enantioselective Determination of (S)-(+)- and (R)-(-)-Ibuprofen in Dog Plasma: Its Application to a Pharmacokinetic Study

Pharmaceutics, 2023
The purpose of this study was to develop a method for simultaneously separating ibuprofen enantiomers using electrospray ionization (ESI) liquid chromatography with tandem mass spectrometry (LC–MS/MS).
Sanghee Choi, Wang-Seob Shim, Jiyoung Yoon, Doowon Choi, Jinseong Lee, Soo-Heui Paik, Eun-Kyoung Chung, Kyung-Tae Lee   +7 more
doaj   +1 more source

Chirality in optical trapping and optical binding [PDF]

, 2015
Optical trapping is a well-established technique that is increasingly used on biological substances and nanostructures. Chirality, the property of objects that differ from their mirror image, is also of significance in such fields, and a subject of much ...
Ahuja, Barron, Bentley, Cintas, Fernandes, Loudon, Subramanian   +6 more
core   +2 more sources

Structural basis of thalidomide enantiomer binding to cereblon

Scientific Reports, 2018
Thalidomide possesses two optical isomers which have been reported to exhibit different pharmacological and toxicological activities. However, the precise mechanism by which the two isomers exert their different activities remains poorly understood. Here,
Tomoyuki Mori, Takumi Ito, Shujie Liu, H. Ando, S. Sakamoto, Y. Yamaguchi, Etsuko Tokunaga, N. Shibata, H. Handa, T. Hakoshima   +9 more
semanticscholar   +1 more source

Enantioseparation Using Cellulose Tris(3,5-dimethylphenylcarbamate) as Chiral Stationary Phase for HPLC: Influence of Molecular Weight of Cellulose

Molecules, 2016
The cellulose oligomers with different degrees of polymerization (DP), 7, 11, 18, 24, 26, 40 and 52, were prepared by hydrolysis of microcrystalline cellulose with phosphoric acid. These oligomers including the starting microcrystalline cellulose (DP 124)
Yuji Okada, Chiyo Yamamoto, Masami Kamigaito, Yuan Gao, Jun Shen, Yoshio Okamoto   +5 more
doaj   +1 more source

Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice

Molecules, 2009
Proteins and peptides in mammals are based exclusively on L-amino acids. Recent investigations show that D-amino acids exhibit physiological effects in vivo, despite of their very small quantities. We have investigated the hepatoprotective effects of the
Dražen Vikić-Topić, Biserka Pokrić, Saša Kazazić, Paško Konjevoda, Tomislav Kelava, Nikola Štambuk, Karlo Houra, Petra Turčić, Mirna Bradamante   +8 more
doaj   +1 more source

Biocatalytic Route to Chiral Precursors of β-Substituted-γ-Amino Acids [PDF]

, 2011
In this work, we utilized commercial lipases (from Thermomyces lanuginosa, Rhizopus delemar, and Mucor miehei) as biocatalysts for the efficient synthesis of precursors of β-substituted-γ-amino acids.
Martinez, Carlos A., Mukherjee, Herschel
core   +2 more sources

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance This report highlights a rare and exciting discovery of an unnatural enantiomer of a natural product [a cyclooligomeric depsipeptide (COD)] that potently inhibits ryanodine receptor type 2 (RyR2), a target for therapeutic development for ...
Suzanne M. Batiste, Daniel J. Blackwell, Kyungsoo Kim, D. O. Kryshtal, N. Gómez-Hurtado, Robyn T. Rebbeck, Răzvan L. Cornea, J. Johnston, B. Knollmann   +8 more
semanticscholar   +1 more source