Results 41 to 50 of about 107,976 (280)

Human UDP-Glucuronosyltransferase 2B4 and 2B7 Are Responsible for Naftopidil Glucuronidation in Vitro

Frontiers in Pharmacology, 2018
Naftopidil (NAF) is widely used for the treatment of benign prostatic hyperplasia and prevention of prostate cancer in elderly men. These patients receive a combination of drugs, which involves high risk for drug–drug interaction.
Xia-Wen Liu, Yi Rong, Xing-Fei Zhang, Jun-Jun Huang, Yi Cai, Bi-Yun Huang, Liu Zhu, Bo Wu, Ning Hou, Cheng-Feng Luo   +9 more
doaj   +1 more source

Antiradical and Antibacterial Activity of Essential Oils from the Lamiaceae Family Plants in Connection with their Composition and Optical Activity of Components

International Journal of Secondary Metabolite, 2018
Antiradical activity of essential oils of korean mint (Agastache rugosa (Fisch. et Mey)), blue giant hyssop (Agastache foeniculum (Pursh) Kuntze), hyssop (Hyssopus officinalis L.), lavander (Lavandula angustifolia L.), peppermint (Mentha piperita L ...
Hanna G. Shutava, Tatsiana G. Shutava, Natalya A. Kavalenka, Halina N. Supichenka   +3 more
doaj   +1 more source

Stereochemistry of Simple Molecules inside Nanotubes and Fullerenes: Unusual Behavior of Usual Systems

Molecules, 2020
Over the past three decades, carbon nanotubes and fullerenes have become remarkable objects for starting the implementation of new models and technologies in different branches of science.
Valerij Kuznetsov
doaj   +1 more source

A stereo-selective growth inhibition profile of ginsenoside Rh2 on human colon cancer cells

CyTA - Journal of Food, 2019
We compared the stereo-selective growth inhibition effects of purified enantiomeric pairs of ginsenoside Rh2 (20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2) on human colon cancer cells in vitro with non-invasive real-time cellular analysis. When 50 μM,
Yunju Jeong, Seockmo Ku, Hyun Ju You, Geun Eog Ji   +3 more
doaj   +1 more source

Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation [PDF]

, 2014
Robenacoxib and ketoprofen are acidic nonsteroidal anti‐inflammatory drugs (NSAIDs). Both are licensed for once daily administration in the cat, despite having short blood half‐lives.
Arifah, Boddy, Bombardier, Brune, Castro, Dayneka, Delatour, Farkouh, Fosse, Foster, Giraudel, Giraudel, Hayball, Higgins, Jung, Kamata, Kelley, King, Kristensen, Kuge, Kuge, Lam, Landoni, Landoni, Landoni, Lees, Lees, Lepist, Littell, Mysler, Nantel, Ollerstam, Owens, Pelligand, Pelligand, Renner, Renner, Rudy, Schmid, Scott, Silverstein, Suesa, Tomlinson, Toutain, Vasquez-Bahena, Viswanathan, Wallace, Warner, Yamaoka   +48 more
core   +1 more source

Homochirality in biomineral suprastructures induced by assembly of single-enantiomer amino acids from a nonracemic mixture

Nature Communications, 2019
Since Pasteur first successfully separated right-handed and left-handed tartrate crystals in 1848, the understanding of how homochirality is achieved from enantiomeric mixtures has long been incomplete.
Wenge Jiang, Dimitra Athanasiadou, Shaodong Zhang, R. Demichelis, Katarzyna B. Koziara, P. Raiteri, V. Nelea, W. Mi, Jun‐An Ma, J. Gale, M. McKee   +10 more
semanticscholar   +1 more source

Enantioselective Protonation of Radical Anion Intermediates in Photoallylation and Photoreduction Reactions of 3,3-Diaryl-1,1-dicyano-2-methylprop-1-ene with Allyltrimethylsilane

Molecules, 2019
Photoreactions of acetonitrile solutions of 3,3-diaryl-1,1-dicyano-2-methylprop-1-enes (1a–c) with allyltrimethylsilane (2) in the presence of phenanthrene as a photoredox catalyst and acetic acid as a proton source formed photoallylation (3) and ...
Hajime Maeda, Masayuki Iida, Daisuke Ogawa, Kazuhiko Mizuno   +3 more
doaj   +1 more source

Total Chiral Symmetry Breaking during Crystallization: Who needs a "Mother Crystal"? [PDF]

, 2005
Processes that can produce states of broken chiral symmetry are of particular interest to physics, chemistry and biology. Chiral symmetry breaking during crystallization of sodium chlorate occurs via the production of secondary crystals of the same ...
Cristobal Viedma, D. K. Kondepudi, F. S. Kipping, K. Soai, R. L. Joesten, R. W. G. Wyckoff, W. A. Bonner, W. A. Bonner   +7 more
core   +3 more sources

Enantiomeric Recognition and Separation by Chiral Nanoparticles

Molecules, 2019
Chiral molecules are stereoselective with regard to specific biological functions. Enantiomers differ considerably in their physiological reactions with the human body.
Ankur Gogoi, Nirmal Mazumder, Surajit Konwer, Harsh Ranawat, Nai-Tzu Chen, Guan-Yu Zhuo   +5 more
doaj   +1 more source

A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. [PDF]

, 2018
We describe here the results from the testing of a small molecule first-in-class apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, A03, that increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic ...
Bai, Dongsheng, Bilousova, Tina, Bredesen, Dale E, Campagna, Jesus, Cole, Gregory, Elias, Chris Jean, Hatami, Asa, Jagodzinska, Barbara, John, Varghese, Jun, Michael, Jung, Michael E, LaDu, Mary Jo, Pham, Johnny, Spilman, Patricia, Zhu, Chunni   +14 more
core   +3 more sources