Results 41 to 50 of about 88,128 (341)

Processes To Separate Enantiomers [PDF]

Angewandte Chemie International Edition, 2014
AbstractThe provision of pure enantiomers is of increasing importance not only for the pharmaceutical industry but also for agrochemistry and biotechnology. In general, there are two rival approaches to provide pure enantiomers. The “chiral” approach is based on developing an asymmetric synthesis of just one of the enantiomers, while the “racemic ...
Lorenz, H., Seidel-Morgenstern, A.
openaire   +3 more sources

Stereodivergent Synthesis of Three Contiguous Stereogenic Centers by Cu/Ir-Catalyzed Borylallylation. [PDF]

Angew Chem Int Ed Engl
An alkene borylallylation strategy enabled by cooperative Cu/Ir‐catalysis has been uncovered for accessing three contiguous stereogenic centres. This strategy is notable given the inherent challenges of constructing molecules with multiple stereocenters while maintaining high selectivity bearing diverse functional groups.
Das S, Dorn SK, Brown MK.
europepmc   +3 more sources

Enantiomeric Recognition and Separation by Chiral Nanoparticles

Molecules, 2019
Chiral molecules are stereoselective with regard to specific biological functions. Enantiomers differ considerably in their physiological reactions with the human body.
Ankur Gogoi, Nirmal Mazumder, Surajit Konwer, Harsh Ranawat, Nai-Tzu Chen, Guan-Yu Zhuo   +5 more
doaj   +1 more source

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. [PDF]

, 2008
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes.
ANZELLOTTI P., ANZINI M., BIAVA M., BOTTA M., CIRILLI R., FERRETTI R., FORLI ., GALLINELLA B., GHELARDINI C., GIORDANI A., LA TORRE F., MAKOVEC F., MANETTI F., NORCINI M., PATRIGNANI P., PERGOLA C., POCE G., PORRETTA G. C., ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, SUPINO S.   +20 more
core   +1 more source

Determination of Enantiomer in Tofacitinib Citrate Using Reversed-Phase Chiral High-Performance Liquid Chromatography

Separations
Tofacitinib citrate (RR-isomer) is a janus kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis (RA) in adults who have had an inadequate response or intolerance to methotrexate. The presence of the enantiomer of tofacitinib citrate (
Xue Wang, Bo Jin, Zhijun Wang, Kaijing Guo, Tingting Zhang, Chen Ma   +5 more
doaj   +1 more source

Pharmacokinetics of ketamine enantiomers

British Journal of Anaesthesia, 1995
Gerd Geißlinger, W. Hering, H.-D. Kamp, K O Vollmers   +3 more
openalex   +3 more sources

A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. [PDF]

, 2018
We describe here the results from the testing of a small molecule first-in-class apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, A03, that increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic ...
Bai, Dongsheng, Bilousova, Tina, Bredesen, Dale E, Campagna, Jesus, Cole, Gregory, Elias, Chris Jean, Hatami, Asa, Jagodzinska, Barbara, John, Varghese, Jun, Michael, Jung, Michael E, LaDu, Mary Jo, Pham, Johnny, Spilman, Patricia, Zhu, Chunni   +14 more
core   +3 more sources

Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance.

PLoS ONE, 2020
The enantiomers of many chiral drugs not only exhibit different pharmacological effects in regard to targets that dictate therapeutic and toxic effects, but are also handled differently in the body due to pharmacokinetic effects.
Grant C Churchill, Michael Strupp, Antony Galione, Frances M Platt   +3 more
doaj   +1 more source

Theory of Chiral Order in Random Copolymers

, 1995
Recent experiments have found that polyisocyanates composed of a mixture of opposite enantiomers follow a chiral ``majority rule:'' the chiral order of the copolymer, measured by optical activity, is dominated by whichever enantiomer is in the majority ...
A. L. Kholodenko, C. J. Eckhardt, C.-M. Chen, D. S. Chung, J. M. Schnur, J. M. Schnur, J. V. Selinger, J. V. Selinger, J. V. Selinger, J. V. Selinger, J.-C. Lin, M. M. Green, M. M. Green, M. Zhang, O. Heinonen, P. Nelson, P.-G. de Gennes, R. L. B. Selinger, R. Viswanathan, R. Zhang, S. Lifson, S. Lifson, T. Nattermann, T. Nattermann, W. Helfrich, Y. Imry   +25 more
core   +2 more sources

Quantum mechanical considerations on algebraic structure of central molecular chirality [PDF]

, 2004
The chiral algebra of tetrahedral molecules, derived from Fischer projections, is discussed in the framework of quantum mechanics. A quantum chiral algebra is obtained whose operators, acting as rotations or inversions, commute with the Hamiltonian of ...
Avalos, Avalos, Barron, Barron, Barron, Capozziello, Capozziello, Eyring, Feringa, Gottfried, Gribbin, Harris, Hassani, Hund, Hund, Janoscheck, Kaku, King, Manson, Mason, McLellan, Quack, Quack, Quack, Wesendrup   +24 more
core   +1 more source