Results 51 to 60 of about 107,976 (280)

Tuning ferroelectric phase transition temperature by enantiomer fraction

Nature Communications
Tuning phase transition temperature is one of the central issues in phase transition materials. Herein, we report a case study of using enantiomer fraction engineering as a promising strategy to tune the Curie temperature (TC) and related properties of ...
Chang‐Chun Fan, Cheng‐Dong Liu, Bei‐Dou Liang, Wei Wang, Ming‐Liang Jin, Chao‐Yang Chai, Chang‐Qing Jing, Tong‐Yu Ju, Xiang‐Bin Han, Wen Zhang   +9 more
semanticscholar   +1 more source

Determination of Enantiomer in Tofacitinib Citrate Using Reversed-Phase Chiral High-Performance Liquid Chromatography

Separations
Tofacitinib citrate (RR-isomer) is a janus kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis (RA) in adults who have had an inadequate response or intolerance to methotrexate. The presence of the enantiomer of tofacitinib citrate (
Xue Wang, Bo Jin, Zhijun Wang, Kaijing Guo, Tingting Zhang, Chen Ma   +5 more
doaj   +1 more source

Metallo-intercalators and metallo-insertors [PDF]

, 2007
Since the elucidation of the structure of double helical DNA, the construction of small molecules that recognize and react at specific DNA sites has been an area of considerable interest.
Barton, Jacqueline K., Pierre, Valerie C., Zeglis, Brian M.   +2 more
core   +1 more source

Identification and Quantitation of Enantiomers by Capillary Electrophoresis and Circular Dichroism Independent of Single Enantiomer Standard.

Analytical Chemistry, 2019
Identification and quantitation of enantiomers is a critical and challenging step in the process of chiral capillary electrophoresis (CE) analysis, especially when the optically pure enantiomers are expensive or commercially unavailable. Herein, a method
Mingxia Liu, Lixia Chen, Tingting Tian, Zhiguo Zhang, Xiangjun Li   +4 more
semanticscholar   +1 more source

Theory of Chiral Order in Random Copolymers

, 1995
Recent experiments have found that polyisocyanates composed of a mixture of opposite enantiomers follow a chiral ``majority rule:'' the chiral order of the copolymer, measured by optical activity, is dominated by whichever enantiomer is in the majority ...
A. L. Kholodenko, C. J. Eckhardt, C.-M. Chen, D. S. Chung, J. M. Schnur, J. M. Schnur, J. V. Selinger, J. V. Selinger, J. V. Selinger, J. V. Selinger, J.-C. Lin, M. M. Green, M. M. Green, M. Zhang, O. Heinonen, P. Nelson, P.-G. de Gennes, R. L. B. Selinger, R. Viswanathan, R. Zhang, S. Lifson, S. Lifson, T. Nattermann, T. Nattermann, W. Helfrich, Y. Imry   +25 more
core   +2 more sources

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. [PDF]

, 2008
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes.
ANZELLOTTI P., ANZINI M., BIAVA M., BOTTA M., CIRILLI R., FERRETTI R., FORLI ., GALLINELLA B., GHELARDINI C., GIORDANI A., LA TORRE F., MAKOVEC F., MANETTI F., NORCINI M., PATRIGNANI P., PERGOLA C., POCE G., PORRETTA G. C., ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, SUPINO S.   +20 more
core   +1 more source

Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance.

PLoS ONE, 2020
The enantiomers of many chiral drugs not only exhibit different pharmacological effects in regard to targets that dictate therapeutic and toxic effects, but are also handled differently in the body due to pharmacokinetic effects.
Grant C Churchill, Michael Strupp, Antony Galione, Frances M Platt   +3 more
doaj   +1 more source

Quantum mechanical considerations on algebraic structure of central molecular chirality [PDF]

, 2004
The chiral algebra of tetrahedral molecules, derived from Fischer projections, is discussed in the framework of quantum mechanics. A quantum chiral algebra is obtained whose operators, acting as rotations or inversions, commute with the Hamiltonian of ...
Avalos, Avalos, Barron, Barron, Barron, Capozziello, Capozziello, Eyring, Feringa, Gottfried, Gribbin, Harris, Hassani, Hund, Hund, Janoscheck, Kaku, King, Manson, Mason, McLellan, Quack, Quack, Quack, Wesendrup   +24 more
core   +1 more source

Enantiomers and Their Resolution

Encyclopedia, 2022
Enantiomers share the same chemical formula but have different chemical structures, i.e., type of isomers. Enantiomers are present in several drugs, perfumes, food, and are a fundamental part of biomolecules.
Rodrigo Santos, Karen V. Pontes, Idelfonso B. R. Nogueira   +2 more
doaj   +1 more source

Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazoles [PDF]

, 2019
New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B.
Carradori, Simone, Chimenti, Paola, Cirilli, Roberto, Guglielmi, Paolo, Petzer, Anél, Petzer, Jacobus P., Poli, Giulio, Rotondi, Giulia, Secci, Daniela   +8 more
core   +1 more source