Results 71 to 80 of about 42,748 (282)
Advanced Science, EarlyView.This study presents a novel approach for intraoperative identification of the IDH1 genotype in glioma patients using a surface‐enhanced Raman scattering (SERS) probe to measure glutathione and hydrogen peroxide. By integrating AI‐driven deep learning algorithms, the method achieves rapid and accurate genotype differentiation, offering the potential to ...
Hang Yin +14 more
wiley +1 more source
Frontiers in Endocrinology, 2016 We are developing an orally available small molecule, allosteric TSH receptor (TSHR) agonist for follow up diagnostics of patients with thyroid cancer.
Susanne Neumann +7 more
doaj +1 more source
Advanced Science, EarlyView.Chiral nano‐inorganics, free of organic chiral ligands, provide a novel platform to direct symmetry breaking in molecular systems, through inorganic‐to‐organic chirality transfer via enantiospecific inorganic–organic interactions, circularly polarized light, and electron spin‐driven enantiopreferential reactions governed by chiral‐induced spin ...
Tao Yao +3 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2016 Single crystal X-ray diffraction has been used as one of the common methods for the unambiguous determination of the absolute stereostructure of chiral molecules.
Reji Thomas, Nobuyuki Tamaoki
doaj +1 more source
A Review of Use of Enantiomers in Homeopathy [PDF]
ISRN Toxicology, 2012 This paper reviews publications of laboratory experiments using pairs of enantiomers in homeopathy. Many molecules in nature have geometry which enables them to exist as nonsuperimposable mirror images or enantiomers. Modulation of toxicity of such molecules provides possibility for therapeutics, since they target multiple points in biochemical ...
openaire +4 more sources
Advanced Science, EarlyView.Chirality governs the limbal epithelial stem cell fate. Right‐handed chirality enhances cell proliferation and differentiation, while left‐handed chirality partially maintains cell stemness. By activating the Notch pathway, 3D right‐handed chiral hydrogel offers a drug‐free and cell‐free strategy for effective corneal regeneration.
Shiding Li +8 more
wiley +1 more source
New Butenolides and Cyclopentenones from Saline Soil-Derived Fungus Aspergillus Sclerotiorum
Molecules, 2019 Three new γ-hydroxyl butenolides (1−3), a pair of new enantiomeric spiro-butenolides (4a and 4b), a pair of enantiomeric cyclopentenones (5a new and 5b new natural), and six known compounds (6−11), were isolated from Aspergillus ...
Li-Ying Ma +6 more
doaj +1 more source
Advanced Science, EarlyView.This work introduces E‐GeoGNN, a graph neural network framework that systematically encodes molecular structural information through three hierarchical correlation graphs: atom‐bond graph, bond‐angle graph, and angle‐dihedral graph. By incorporating quantum and geometric dual‐scale self‐supervised pretraining, Q‐GEM is proposed, a novel molecular ...
Zhijiang Yang +7 more
wiley +1 more source
Molecules, 2015 Pyridinesulfonamide is an important fragment which has a wide range of applications in novel drugs. R- and S-isomers of 5-bromo-2-chloro-N-(1-phenylethyl)pyridine-3-sulfonamide have been synthesized, and the stereostructures have been researched.
Zhixu Zhou +5 more
doaj +1 more source
Advanced Science, EarlyView.FM‐DEL1 and FM‐DEL2 are constructed by installing one or two sets of building blocks on a phenylalanine central scaffold. FM‐DELs are screened against markers of prostate, and renal cell carcinoma, and against an immunological target expressed on the surface of natural killer cells.
Francesca Migliorini +12 more
wiley +1 more source