Results 101 to 110 of about 10,075 (214)

Effect of molecular perturbation on cocrystal formation: theophylline and its 8‐halo analogues with flavonoids

Acta Crystallographica Section C, EarlyView.
The tendency for alkaloid–flavonoid cocrystal formation is found to be markedly different for theophylline (Tph) compared to its 8‐halo analogues. Through screening with 13 common flavonoids, Tph is found to form cocrystals with six flavonoids, whereas 8‐Cl‐Tph and 8‐Br‐Tph each form cocrystals with just two, myricetin and kaempferol.
Weijian Ye, Herman H-Y. Sung, Ian D. Williams   +2 more
wiley   +1 more source

Catalytic Enantioselective Multicomponent Reactions of Sulfoxonium Ylides Enabled by a Formal Rearrangement—A Versatile Entry to Enantioenriched α‐Sulfanyl Carbonyl Compounds

Angewandte Chemie, Volume 138, Issue 28, 6 July 2026.
A catalytic network embedding a formal rearrangement enables the first catalytic enantioselective multicomponent reaction (MCR) of sulfur ylides. In the presence of a bulky chiral phosphoric acid, the reaction combines sulfoxonium ylides, aldehydes and thiols, and affords synthetically versatile β‐hydroxy‐α‐sulfanyl carbonyl compounds in ...
Nicolò Santarelli, Pietro Pecchini, Nunzio Matera, Andrea Pellegrini, Riccardo Fabbri, Irati Celada Cubero, Leire Navarro Rubio, Cristina Di Pietro, Andrea Mazzanti, Mariafrancesca Fochi, Luca Bernardi   +10 more
wiley   +2 more sources

Kinetics of enzyme-catalysed desymmetrisation of prochiral substrates: product enantiomeric excess is not always constant. [PDF]

Beilstein J Org Chem, 2021
Halling PJ.
europepmc   +1 more source

Temperature interacts with jack pine host defences to influence the growth of mountain pine beetle‐associated fungi

Agricultural and Forest Entomology, EarlyView.
Optimal growing temperatures varied with mountain pine beetle‐associated fungal species. There was only a marginal impact of temperature on the response of fungi to defensive monoterpenes of novel host pine. Interspecific facilitation occurred for Leptiographuim longiclavatum when grown in Ophiostoma montium‐induced treatments at optimal temperatures ...
Adrienne C. Bailey, Jennifer G. Klutsch, Kaitlyn Carey, Laureen F. I. Echiverri, Leah Flaherty   +4 more
wiley   +1 more source

Selected Ion Monitoring Using Low-Cost Mass Spectrum Detectors Provides a Rapid, General, and Accurate Method for Enantiomeric Excess Determination in High-Throughput Experimentation. [PDF]

ACS Catal, 2022
Korch KM, Hayes JC, Kim RS, Sampson J, Kelly AT, Watson DA.   +5 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

One-pot analysis of enantiomeric excess of free amino acids by electrospray ionization mass spectrometry. [PDF]

RSC Adv, 2021
Nakakoji T, Sato H, Ono D, Miyake H, Mieda E, Shinoda S, Tsukube H, Kawasaki H, Arakawa R, Shizuma M.   +9 more
europepmc   +1 more source

Serine Octamer Substitution Reactions With α‐Hydroxy Acids

Rapid Communications in Mass Spectrometry, Volume 40, Issue 18, 30 September 2026.
ABSTRACT Rationale The amino acid serine forms chiral magic number clusters, which can be studied using mass spectrometry (MS). Serine octamer clusters are also known to incorporate one or two nonserine monomers with serine monomers to make up the octamer.
Keerthana Unni, Brison A. Shira, Dylan T. Holden, Thalappil Pradeep, R. Graham Cooks   +4 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.
Sule Erol Gunal, Senel Teke Tuncel, İlke Demir, İpek Baysal, Gökçen Telli, Safiye Sag Erdem, Gulberk Ucar, Michaela Hanzlova, Kamil Musilek, İlknur Dogan, Nesrin Gokhan Kelekci   +10 more
wiley   +1 more source

Development of an Efficient Stereoretentive Para‐Claisen‐Cope Rearrangement

ChemistryEurope
A stereoretentive para‐Claisen‐Cope rearrangement of chiral aryl‐allyl ethers is reported, achieving near‐perfect chirality transfer thereby furnishing products with exceptional enantiomeric excess (up to > 98% ee) as single regioisomers.
Johanna Breinsperger, Maximilian Kaiser, Nicolas Kratena, Peter Gärtner   +3 more
doaj   +1 more source