Results 131 to 140 of about 10,075 (214)

Enantiomeric Excess Bupivacaine in a Lavender Oil NLC Tested in a Melanoma Model: Prolonged Release and Anticancer Effect. [PDF]

Mol Pharm
Geronimo G, Rodrigues da Silva GH, de Moura LD, de Carvalho FV, Mendonça TC, Olivo LB, Verlindo de Araújo B, Dalla Costa TC, Lavareze L, Mariano FV, de Paula E.   +10 more
europepmc   +1 more source

A Hydrogen‐Bonded Organic Biradical in the Gas Phase

Journal of Physical Organic Chemistry, Volume 39, Issue 7, July 2026.
Hydrogen‐bonded dimers of the TEMPOL radical are investigated by vibrational spectroscopy in the gas phase and shown to occur in at least two conformations, a stretched one with a strong hydrogen bond to the radical centre and a bent one with more pronounced London dispersion interactions. ABSTRACT Persistent organic radicals from the TEMPO family such
Dana Donnerstag, Elisabeth Sennert, Martin A. Suhm   +2 more
wiley   +1 more source

Discovery of pseudobaptigenin synthase in fungal‐infected Trifolium pratense roots

The Plant Journal, Volume 127, Issue 1, July 2026.
Significance Statement The discovery of pseudobaptigenin synthase in red clover (CYP76F319), catalyzing the formation of a methylenedioxy bridge to convert calycosin to pseudobaptigenin. The integration of metabolomic and transcriptomic datasets to describe the defense response in red clover roots to hemibiotrophic and necrotrophic fungi.
Lee Marie Raytek, Lan Liu, Stéphane Bayen, Mehran Dastmalchi   +3 more
wiley   +1 more source

Merging Biocatalysis and Chemocatalysis in Flow: State‐of‐the‐Art and Future Directions for Sustainable Synthesis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis, Matteo Damian, Francesco G. Mutti   +2 more
wiley   +2 more sources

Crystal Structure and Conformational Dynamics of N─N Bond‐Forming Piperazate Synthase

ChemBioChem, Volume 27, Issue 12, 26 June 2026.
Piperazate synthases (PZSs) catalyze the key N─N bond formation in the biosynthesis of the rare amino acid piperazic acid. X‐ray crystal structures of apo‐ and holo‐SbPZS show a dimeric enzyme with two heme‐containing active sites, where histidine residues coordinate the iron centers.
Nikita Pal, Simon Schröder, Amit Singh Sahrawat, Christian C. Gruber, Martin A. Hayes, Bastian Daniel, Sandy Schmidt, Karl Gruber   +7 more
wiley   +1 more source

Spiro‑Linked Double Tetraphenylethenes: Solid‐State Emission and Circularly Polarized Luminescence Imaging

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Two spirobisanthracene‐tetraphenylethene (SBA‐TPE) hybrid compounds are synthesized and their photophysical properties in the solid state reported. Circularly polarized luminescence in aggregates, films and dispersions is evaluated. Circularly polarized luminescence imaging is evaluated over crystals revealing discrimination of different types of ...
José L. Páez, Riccardo Rubino, Giulia Micolonghi, Marco Reale, Alice Sciortino, Victor Blanco, Angel Orte, Carlos M. Cruz   +7 more
wiley   +2 more sources

Synthesis of 2‐Aza‐Bicyclo[4.3.0]nonane Derivatives Related to the Camporidines via Intramolecular [3+2]‐Cycloaddition

European Journal of Organic Chemistry, Volume 29, Issue 24, 23 June 2026.
The intramolecular nitrile oxide olefin [3 + 2]‐cycloaddition offers a reliable entry toward 2‐aza‐bicyclo[4.3.0]‐nonanes, a substructure found in several bioactive piperidine alkaloids. The required oxime precursors were prepared in non‐racemic form by Ir‐catalyzed asymmetric allylation and ring‐closing metathesis.
Alicia Köcher, Tobias Wilczek, Nora Katharina Korber, Jörg-Martin Neudörfl, Bernd Goldfuss, Hans-Günther Schmalz   +5 more
wiley   +1 more source

Lithium Diisopropylamide‐Mediated Ring‐Opening of Tetrahydrofuran in the Synthesis of Polyhydroxylated Indolizidines

European Journal of Organic Chemistry, Volume 29, Issue 24, 23 June 2026.
Chiral tri‐ and pentahydroxy spirocyclopentane‐indolizidines were synthesized using lithium diisopropylamide “LDA” promoted diallylation and tetrahydrofuran “THF” ring‐opening in a one‐pot procedure as a key step. The sequence leading to the targeted hydroxy‐spiroindolizidines was achieved by cis‐dihydroxylation followed by reduction of the enamine and
Paula Fraňová, Peter Šafář, Marchalín Štefan, Petra Pažitná, Ivana Žídeková, Ján Moncol, Adam Daïch   +6 more
wiley   +1 more source

Asymmetric Michael Addition of Cyanide to α,β‐Unsaturated Aldehydes Catalyzed by Diarylmethyl‐Substituted Diphenylprolinol Silyl Ethers: Thermodynamically Controlled Product Formation under Kinetic Enantioselective Catalysis

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
Asymmetric Michael addition of cyanide to α,β‐unsaturated aldehydes catalyzed by diarylmethyl‐substituted diphenylprolinol silyl ethers:Thermodynamically controlled product formation under kinetic enantioselective catalysis. Diphenylprolinol silyl ether catalyzed asymmetric Michael/1,2‐addition reaction of cyanide to α,β‐unsaturated aldehydes at high ...
Konstantinos Daskalakis, Naoki Mori, Satrajit Indu, Riku Fukami, Yujiro Hayashi   +4 more
wiley   +1 more source

1,1‐and 1,2‐Diborylalkenes: Preparation and Synthetic Applications

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
In this review, we highlight recent advances in the synthesis and reactivity of 1,1‐diborylalkenes and 1,2‐diborylalkenes, along with various transformations leading to C‐C, C‐heteroatom, and multicomponent products. By providing a comprehensive and practical resource, this review aims to assist researchers in exploring the synthetic utility of 1,1 and
Jayaram Vankudoth, Maruti Mali, Fabienne Berrée   +2 more
wiley   +1 more source