Results 171 to 180 of about 691,764 (293)

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D‐Peptide‐Ruthenium Prodrug Conjugate

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang, Peiyuan Wang, Hildert Bronkhorst, Yurii Husiev, Ludovic Bretin, Maarten N. van Ginkel, Wen Sun, Sylvestre Bonnet   +7 more
wiley   +1 more source

Coumarin-Containing Chiral Discriminating Agents. VII. New Crystalline <SUP>1</SUP>H-NMR Enantiomeric Excess Determination Reagent for Alcohols and Amines, (R)-(-)- and (S)-(+)-O-Coumarinylmandelic Acids

, 1997
Kazuo Nagasawa, Nobuyuki Seto, C Hara, Kiyonori Ito   +3 more
openalex   +2 more sources

Biocatalytic Asymmetric Michael Addition of Thiols to α,β‐Unsaturated Aldehydes via Enzyme‐Bound Iminium Ion Intermediates

Advanced Synthesis &Catalysis, Volume 368, Issue 3, 3 February 2026.
Biocatalytic stereo‐controlled C–S bond formation unlocked! Engineered, cofactor‐independent 4‐oxalocrotonate tautomerase variants catalyze enantioselective thia‐Michael additions of aliphatic thiols to cinnamaldehyde, affording (R)‐β‐thioenals with up to 99% conversion and high enantiopurity (up to 95:5 e.r.).
Michele Crotti, Pieter G. Tepper, Thim de Jong, Gerrit J. Poelarends   +3 more
wiley   +1 more source

Design and Experimental Validation of a Photocatalyst Recommender Based on a Large Language Model

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Choosing a photocatalyst for a given reaction can be challenging due to complex mechanisms and multiple parameters that govern the outcome of a photocatalyzed reaction. Herein, we disclose a machine learning (ML) model that can suggest catalysts for a given reaction using an online portal.
Francis Millward, Michał Kulczykowski, Jay Badland‐Shaw, Sara Szymkuc, Rajan Suraksha, Aniket Kumar Srivastawa, Violaine Manet, Máire Griffin, Megan Bryden, Thomas Comerford, Lea Hämmerling, Aminata Mariko, Bartosz A. Grzybowski, Eli Zysman‐Colman   +13 more
wiley   +2 more sources

ENANTIOMERIC EXCESS MEASUREMENTS OF ISOPULEGOL USING CHIRAL TAG SPECTROSCOPY [PDF]

, 2018
Kevin Mayer, Luca Evangelisti, Brooks H. Pate, Caitlin Embly   +3 more
openalex   +1 more source

Molecular basis and biological relevance of bacterial and plant pinoresinol/lariciresinol reductase specificities

Protein Science, Volume 35, Issue 2, February 2026.
Abstract A bacterial pinoresinol/lariciresinol reductase (PLR) homolog named NrPinZ was obtained from a Novosphingobium rhizosphaerae sp. LY bacterial strain, with NrPinZ being part of its 5‐step biochemical system catabolizing pinoresinol into coniferyl aldehyde and vanillin.
Clyde A. Smith, Diana L. Bedgar, Michael A. Costa, Syed G. A. Moinuddin, Marco N. Allemann, Joshua K. Michener, Laurence B. Davin, Norman G. Lewis   +7 more
wiley   +1 more source

WILL CHIRAL TAG ROTATIONAL SPECTROSCOPY ALWAYS GIVE ACCURATE ENANTIOMERIC EXCESS DETERMINATATIONS? [PDF]

, 2023
Brooks H. Pate, Chambers Taylor Heman-Ackah   +1 more
openalex   +1 more source

Estrone‐α‐2‐Deoxy‐Glucoside as a Targeted Therapy for Triple‐Negative Breast Cancer: Aromatase Inhibition and Cytotoxicity

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Estrone‐α‐2DG, synthesized via a one‐pot multi‐enzyme system, selectively inhibits aromatase (IC50 = 0.101μM) and triple negative breast cancer cells (IC50 = 20.46 μM), offering a dual function therapeutic scaffold. ABSTRACT Aromatase inhibitors (AIs) are vital in the treatment of estrogen‐dependent breast cancer, especially in postmenopausal women. In
Tzu‐Yu Huang, Meng‐Ru Wang, Feng‐Pai Chou, Sheng‐Cih Huang, Po‐Yun Hsiao, Tung‐Kung Wu   +5 more
wiley   +1 more source

EnzyKR: a chirality-aware deep learning model for predicting the outcomes of the hydrolase-catalyzed kinetic resolution. [PDF]

Chem Sci, 2023
Ran X, Jiang Y, Shao Q, Yang ZJ.
europepmc   +1 more source

Enantioselective Syntheses of Secondary Alkylboronates via Asymmetric Regioselective Reduction of 1,3‐Dienylboronates

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
We report herein the development of catalytic asymmetric synthesis of secondary alkyl boronates. Under the optimal conditions, Cu‐catalyzed semi‐reduction of 1‐alkyl‐ or 1,3‐dialkyl‐substituted 1‐boryl‐1,3‐butadienes forms secondary alkyl boronates with excellent regioselectivities and enantioselectivities.
Wen‐Bin Cao, Lingfei Hu, Jiaming Liu, George Chen, Gang Lu, Ming Chen   +5 more
wiley   +2 more sources