Results 101 to 110 of about 3,249 (212)
MoleculesThe tetrahydroisoquinoline skeleton is a pharmacologically significant core structure containing chiral centers, making enantiomeric separation crucial due to the potentially distinct biological effects of each enantiomer.
Erzsébet Várnagy +5 more
doaj +1 more source
Enantioseparation using chromatography and crystallization
, 2010 Due to the improved availability of selective stationary phases and recent developments of more productive operating modes, the number of applications of chiral preparative chromatography has been increased in the last years.
Seidel-Morgenstern, A.
core
Enantioseparation condition of D,L-tryptophan using ligand exchange chromatography
, 2008 75-80Chiral recognition mechanism and enantioseparation conditions of tryptophan enantiomers using ligand exchange chromatography are reported here. The effect of different kinds and concentration of ligands, bivalent copper ion, organic modifier, pH of ...
Yan, Hongyuan, Row, Kyung Ho
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Separations3,4-Methylenedioxypyrovalerone (MDPV) is an emerging, chiral, new psychoactive substance belonging to the synthetic cathinones group that has been frequently detected in wastewater effluents and aquatic environments.
Ariana Pérez-Pereira +6 more
doaj +1 more source
Monte Carlo simulation of the enantioseparation process
, 2012 By means of Monte Carlo simulation, a study of enantioseparation by capillary electrophoresis has been carried out. A simplified system consisting of two enantiomers S (R) and a selector chiral C, which reacts with the enantiomers to form complexes RC ...
Bustos Giunta, Victor Angel +3 more
core +1 more source
Thermodynamic Study on the Enantioseparation of Benzoin on a Chiralcel OD-RH Column
, 2007 利用Chiralcel OD-H手性柱拆分外消旋安息香化合物制备单一对映体标样,并对其进行圆二色光谱表征。在此基础上,采用甲醇、乙醇、乙腈为流动相考察了安息香在Chiralcel OD-RH柱上的色谱拆分行为和热力学特性。结果表明:以纯甲醇为洗脱液时,(S)-构型先出峰,安息香的拆分过程为焓控;以纯乙醇为洗脱液时,(R)-构型先出峰,拆分过程为熵控;而以纯乙腈为洗脱液时,虽然也是(R)-构型先出峰,但熵和焓对拆分均有贡献。文中还对比了安息香在Chiralcel OD-H柱的拆分性能。This paper
邱进坤, 阮源萍, 成芳
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, 2013 The HPLC enantioseparation of nine atropisomeric 3,3,5,5-tetrasubstituted-4,4- bipyridines was performed in normal and polar organic (PO) phase modes using two immobilized polysaccharide-based chiral columns, namely, Chiralpak IA and Chiralpak IC. The
Aubert, Emmanuel +8 more
core +1 more source
Crystallization of enantiomers : from the phase diagram to crystallization based enantioseparation
Often it is not recognized that crystallization methods can be applied for enantioseparation purposes. Thus, the intention of this lecture is to present and to discuss several aspects relevant to derive the feasibility of crystallization based ...
Lorenz, H.
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