Results 91 to 100 of about 5,412 (216)

A Novel Two-Step Liquid-Liquid Extraction Procedure Combined with Stationary Phase Immobilized Human Serum Albumin for the Chiral Separation of Cetirizine Enantiomers along with M and P Parabens

Molecules, 2016
The research into the separation of drug enantiomers is closely related to the safety and efficiency of the drugs. The aim of this study was to develop a simple and validated HPLC method to analyze cetirizine enantiomers.
Aleksandra Chmielewska, Lucyna Konieczna, Tomasz Bączek   +2 more
doaj   +1 more source

Molecular modeling studies, synthesis, configurational stability and biological activity of 8-chloro-2,3,5,6-tetrahydro-3,6-dimethyl-pyrrolo[1,2,3-de]-1,2,4-benzothiadiazine 1,1-dioxide [PDF]

, 2011
The potential therapeutic benefit of compounds able to activate AMPA receptors (AMPArs) has led to a search for new AMPAr positive modulators. Among them, 8-chloro-2,3,5,6-tetrahydro-3,6-dimethyl-pyrrolo[1,2,3-de]-1,2,4-benzothiadiazine 1,1-dioxide (1 ...
Battisti, UMBERTO MARIA, Braghiroli, Daniela, Cannazza, Giuseppe, Carrozzo, Marina Maria, Giulia,, K., Jozwiak, L., Troisi, Parenti, Carlo, Puja, Giulia   +8 more
core   +1 more source

HPLC and SFC Enantioseparation of (±)-Trans-β-Lactam Ureas on Immobilized Polysaccharide-Based Chiral Stationary Phases—The Introduction of Dimethyl Carbonate as an Organic Modifier in SFC

Separations
A series of nine racemic trans-β-lactam ureas were analyzed for enantiomer separation by high-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC).
Mladenka Jurin, Darko Kontrec, Marin Roje   +2 more
doaj   +1 more source

Quantum chemistry calculation aided design of chiral ionic liquid-based extraction system for amlodipine separation [PDF]

, 2018
Amlodipine is a widely used medication in treating hypertension, which is also known as a chiral compound. So far efforts have been made to obtain optically pure (S)-amlodipine because (R)-amlodipine has poor efficacy and is ...
Becke, Bhattacharyya, Boys, Cao, Cui, Dong, Fileti, Fileti, Frisch, Fumio, Gong, Gotrane, Grimme, Holbach, Kapnissi-Christodoulou, Keith, Kimaru, Latosińska, Lee, Lee, Meng, Meredith, Parr, Peng, Po, Schuur, Sesin, Sun, Sun, Sunsandee, Tang, Tang, Tang, Tao, Wang, Wu, Wu, Xie, Xing, Yang, Yang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao   +48 more
core   +1 more source

Enzymatic and chromatographic resolution procedures applied to the synthesis of the phosphoproline enantiomers [PDF]

, 2015
Financial support to this work was provided by Ministerio de Economía y Competitividad–FEDER (grants CTQ2011-24237,CTQ2013-44153-P, and CTQ2013-40855 ...
Arizpe, Alicia, Cativiela, Carlos, Gotor Fernández, Vicente, Gotor Santamaría, Vicente Miguel, Jiménez, Ana I., Pueyo, María J., Rodríguez Mata, María, Sayago García, Francisco Javier   +7 more
core   +2 more sources

Enantioseparation by Dual-flow Countercurrent Extraction: Its Application to the Enantioseparation of (.+-.)-Propranolol.

Chemical and Pharmaceutical Bulletin, 1996
Enantioseparation of (±)-propranolol has been demonstrated by countercurrent extraction with a two-phase system composed of a chloroform solution of didodecyl L-tartrate (100mM) and an acetate buffer (50mM, pH 4.4) containing boric acid (100mM). The free base of (±)-propranolol (1.6g) was dissolved in the aqueous phase and extracted five times by means
Yoshiohiro ABE, Tomoko SHOJI, Shikie FUKUI, Maki SASAMOTO, Hideyuki NISHIZAWA   +4 more
openaire   +2 more sources

Chirality in optical trapping and optical binding [PDF]

, 2015
Optical trapping is a well-established technique that is increasingly used on biological substances and nanostructures. Chirality, the property of objects that differ from their mirror image, is also of significance in such fields, and a subject of much ...
Ahuja, Barron, Bentley, Cintas, Fernandes, Loudon, Subramanian   +6 more
core   +2 more sources

The enantioselective potential of amylose tris(3‑chloro-5-methylphenyl carbamate)-based chiral stationary phase in sub/supercritical fluid and normal phase liquid chromatography

Journal of Chromatography Open
The enantioselective potential of amylose tris (3‑chloro-5-methylphenylcarbamate) based chiral stationary phase in sub/supercritical fluid chromatography and normal phase liquid chromatography was evaluated.
Denisa Folprechtová, Patricia Maestro Martínez, Květa Kalíková   +2 more
doaj   +1 more source

Dynamical Casimir-Polder interaction between a chiral molecule and a surface

, 2015
We develop a dynamical approach to study the Casimir-Polder force between a initially bare molecule and a magnetodielectric body at finite temperature.
Barcellona, Pablo, Buhmann, Stefan Yoshi, Passante, Roberto, Rizzuto, Lucia   +3 more
core   +1 more source

Preparative separation of profen enantiomers by liquid chromatography [PDF]

, 2007
Profens. or 2•aryfpropionic acids. are an important sub-class of the frequently prescribed non-steraidal anti-inflammatory drugs (NSAIDs). Some of the main primary indications for NSAIDs therapy include rheumatoid arthritis, osteoarthritis, acute gouty
Graça, Nuno S., Pais, Luís S., Ribeiro, António E., Rodrigues, Alírio   +3 more
core   +3 more sources