Results 161 to 170 of about 3,249 (212)
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Recent advances in electrodriven enantioseparations
Journal of Separation Science, 2012Capillary electromigration techniques have developed into significant analytical separation tools especially for enantioseparations. While CE can be considered a mature technique as documented by its wide applications, CEC is still in a developmental state despite many research efforts.
Pavel, Jáč, Gerhard K E, Scriba
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Enantioseparation of nonproteinogenic amino acids
Analytical and Bioanalytical Chemistry, 2009The enantioseparation of structurally related N-protected beta-/gamma-amino acids, beta-/gamma-amino amides, and beta-/gamma-amino nitriles by using six different commercially available chiral stationary phases (CSPs) is reported. The synthetic key step to introduce stereochemical asymmetry into all compounds is an enzymatic kinetic resolution of the ...
Margit, Winkler, Norbert, Klempier
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Homochiral metal–organic frameworks for enantioseparation
Chemical Society Reviews, 2021Contextualising rational structural design, according to the enantioselective mechanisms of homochiral metal–organic frameworks, we discuss enantioselective separations primed to deliver purification performances and analytical utilities thereof.
Juan Liu +4 more
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Apparent and true enantioselectivity in enantioseparations
Chirality, 2000The separation factor of two compounds in chromatography is the ratio of their equilibrium constants or retention factors. This parameter is universally employed to investigate their resolution and to optimize the experimental conditions of their analysis. In enantioseparations, the situation is more complex because there is a mixed retention mechanism.
G, Götmar, T, Fornstedt, G, Guiochon
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Enantioseparations by Thin-Layer Chromatography
2012An up-to-date overview of thin-layer chromatography (TLC) techniques for chiral separations of various significant and/or recent examples of enantioresolutions is reported. Furthermore, examples for chiral separations obtained on achiral commercially available C18 TLC plates are described in detail.
DEL BUBBA, MASSIMO +3 more
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Liquid-liquid chromatography in enantioseparations
Journal of Chromatography A, 2020Modern liquid-liquid chromatography mainly refers to the following two kinds of chromatographic apparatuses: countercurrent chromatography based on hydrodynamic equilibrium systems and centrifugal partition chromatography based on hydrostatic equilibrium systems.
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Chirality, 2018 Supercritical fluid chromatography (SFC) is already used for enantioseparation in the pharmaceutical industry, but it is rarely used for the separation of chiral pesticides.
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Enantioseparation by Thin-Layer Chromatography
2019Despite the fact that high-performance liquid chromatography is the predominant technique for analytical and preparative enantioseparations, chiral thin-layer chromatography (TLC) may represent an alternative, especially if fast analysis with simple equipment is required.
Rituraj, Dubey, Ravi, Bhushan
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Recent advances in microchip enantioseparation and analysis
ELECTROPHORESIS, 2020AbstractThis review summarizes recent developments (over the past decade) in the field of microfluidics‐based solutions for enantiomeric separation and detection. The progress in various formats of microchip electrodriven separations, such as MCE, microchip electrochromatography, and multidimensional separation techniques, is discussed.
Nan Lu, Jörg P. Kutter
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Supercritical fluid chromatography for the enantioseparation of pharmaceuticals
Journal of Pharmaceutical and Biomedical Analysis, 2012Chirality has a significant impact on drug discovery and development processes in the pharmaceutical industry. As the number of enantiopure drugs launched onto the market is yearly increasing, the need for fast and performant enantioseparation methods with minimal costs is becoming more compelling.
Katrijn, De Klerck +2 more
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