Results 161 to 170 of about 3,397 (210)
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Enantioseparation of nonproteinogenic amino acids
Analytical and Bioanalytical Chemistry, 2009The enantioseparation of structurally related N-protected beta-/gamma-amino acids, beta-/gamma-amino amides, and beta-/gamma-amino nitriles by using six different commercially available chiral stationary phases (CSPs) is reported. The synthetic key step to introduce stereochemical asymmetry into all compounds is an enzymatic kinetic resolution of the ...
Margit, Winkler, Norbert, Klempier
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Apparent and true enantioselectivity in enantioseparations
Chirality, 2000The separation factor of two compounds in chromatography is the ratio of their equilibrium constants or retention factors. This parameter is universally employed to investigate their resolution and to optimize the experimental conditions of their analysis. In enantioseparations, the situation is more complex because there is a mixed retention mechanism.
G, Götmar, T, Fornstedt, G, Guiochon
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Enantioseparations by Thin-Layer Chromatography
2012An up-to-date overview of thin-layer chromatography (TLC) techniques for chiral separations of various significant and/or recent examples of enantioresolutions is reported. Furthermore, examples for chiral separations obtained on achiral commercially available C18 TLC plates are described in detail.
DEL BUBBA, MASSIMO +3 more
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Liquid-liquid chromatography in enantioseparations
Journal of Chromatography A, 2020Modern liquid-liquid chromatography mainly refers to the following two kinds of chromatographic apparatuses: countercurrent chromatography based on hydrodynamic equilibrium systems and centrifugal partition chromatography based on hydrostatic equilibrium systems.
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Enantioseparation by Thin-Layer Chromatography
2019Despite the fact that high-performance liquid chromatography is the predominant technique for analytical and preparative enantioseparations, chiral thin-layer chromatography (TLC) may represent an alternative, especially if fast analysis with simple equipment is required.
Rituraj, Dubey, Ravi, Bhushan
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Recent advances in microchip enantioseparation and analysis
ELECTROPHORESIS, 2020AbstractThis review summarizes recent developments (over the past decade) in the field of microfluidics‐based solutions for enantiomeric separation and detection. The progress in various formats of microchip electrodriven separations, such as MCE, microchip electrochromatography, and multidimensional separation techniques, is discussed.
Nan Lu, Jörg P. Kutter
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Supercritical fluid chromatography for the enantioseparation of pharmaceuticals
Journal of Pharmaceutical and Biomedical Analysis, 2012Chirality has a significant impact on drug discovery and development processes in the pharmaceutical industry. As the number of enantiopure drugs launched onto the market is yearly increasing, the need for fast and performant enantioseparation methods with minimal costs is becoming more compelling.
Katrijn, De Klerck +2 more
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Enantioseparations of pharmaceuticals with capillary electrochromatography: A review
Journal of Pharmaceutical and Biomedical Analysis, 2016The chiral separation of pharmaceuticals is one of the major research topics in the pharmaceutical industry. Chromatographic techniques are most frequently used in this context. Separations in capillary electrochromatography (CEC) are an alternative and achieved by chromatographic retention and electrophoretic mobility principles.
Declerck, Sven +2 more
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Modeling and Optimization of Enantioseparation by Capillary Electrochromatography
Analytical Chemistry, 1998Both electrophoretic and chromatographic transport mechanisms are combined in electrochromatographic separation. In this paper, we developed a model of enantioselectivity in capillary electrochromatography (CEC) which can be applied in the separation of both neutral and ionic compounds.
Y, Deng +5 more
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Planar Chromatography Enantioseparations on Noncommercial CCSPs
2007Numerous chiral stationary phases were used for the direct separation of optical isomers in planar chromatography. Only few stationary phases have been commercialized as precoated plates because of the high cost of most chiral adsorbents and the difficulty to detect analytes on stationary phases showing a strong adsorbance during exposition to ...
LEPRI, LUCIANO +2 more
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