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Supercritical fluid chromatography for the enantioseparation of pharmaceuticals
Journal of Pharmaceutical and Biomedical Analysis, 2012Chirality has a significant impact on drug discovery and development processes in the pharmaceutical industry. As the number of enantiopure drugs launched onto the market is yearly increasing, the need for fast and performant enantioseparation methods with minimal costs is becoming more compelling.
Katrijn, De Klerck +2 more
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Planar Chromatography Enantioseparations on Noncommercial CCSPs
2007Numerous chiral stationary phases were used for the direct separation of optical isomers in planar chromatography. Only few stationary phases have been commercialized as precoated plates because of the high cost of most chiral adsorbents and the difficulty to detect analytes on stationary phases showing a strong adsorbance during exposition to ...
LEPRI, LUCIANO +2 more
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Modeling and Optimization of Enantioseparation by Capillary Electrochromatography
Analytical Chemistry, 1998Both electrophoretic and chromatographic transport mechanisms are combined in electrochromatographic separation. In this paper, we developed a model of enantioselectivity in capillary electrochromatography (CEC) which can be applied in the separation of both neutral and ionic compounds.
Y, Deng +5 more
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Enantioseparations of pharmaceuticals with capillary electrochromatography: A review
Journal of Pharmaceutical and Biomedical Analysis, 2016The chiral separation of pharmaceuticals is one of the major research topics in the pharmaceutical industry. Chromatographic techniques are most frequently used in this context. Separations in capillary electrochromatography (CEC) are an alternative and achieved by chromatographic retention and electrophoretic mobility principles.
Declerck, Sven +2 more
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Enantioseparation in microfluidic channels
Chemical Physics, 2010Abstract Since the pharmaceutical or biological activity of enantiomers may be significantly different for the two chiral partner molecules, the separation of a racemic mixture into its component enantiomers represents a challenge of immense practical relevance.
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Enantioseparation by Thin-Layer Chromatography
Both high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC) techniques should be considered complementary rather than competing, with TLC being used widely in organic synthesis and analytical research. Chiral TLC provides an easy technique for the resolution, isolation, and routine quality control of the enantiomeric purity ...openaire +2 more sources
Enantioseparations in super- and subcritical fluid chromatography
Journal of Chromatography A, 2001The separation of chiral compounds by sub- and supercritical fluid chromatography has been a field of great progress since the first demonstration of a chiral separation by SFC in 1985. Almost all of the chiral selectors used in gas or liquid chromatography have been successfully applied to sub-/supercritical chromatography.
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Contemporary theory of enantioseparations in capillary electrophoresis
Journal of Chromatography A, 2018The first separation of enantiomers in capillary electrophoresis (CE) counts slightly longer than three decades. Fast development of the practice and theory of chiral CE occurred in the past 30 years and today one can consider this technology to have a solid and mature theoretical background.
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