Results 171 to 180 of about 5,412 (216)

Liquid-liquid chromatography in enantioseparations

Journal of Chromatography A, 2020
Modern liquid-liquid chromatography mainly refers to the following two kinds of chromatographic apparatuses: countercurrent chromatography based on hydrodynamic equilibrium systems and centrifugal partition chromatography based on hydrostatic equilibrium systems.
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Enantioseparation by Thin-Layer Chromatography

2019
Despite the fact that high-performance liquid chromatography is the predominant technique for analytical and preparative enantioseparations, chiral thin-layer chromatography (TLC) may represent an alternative, especially if fast analysis with simple equipment is required.
Rituraj, Dubey, Ravi, Bhushan
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Enantioseparation using helical polyacetylene derivatives

TrAC Trends in Analytical Chemistry, 2020
Abstract In the past few decades, the enantioseparations techniques have been quickly developed in order to meet the needs of single enantiomers in many fields. Polyacetylene derivatives have attracted considerable attention due to their rigid conjugated backbone with high stereoregularity that can be readily induced into a regular helical ...
Chunhong Zhang, Lijia Liu, Yoshio Okamoto   +2 more
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Planar Chromatography Enantioseparations on Noncommercial CCSPs

2007
Numerous chiral stationary phases were used for the direct separation of optical isomers in planar chromatography. Only few stationary phases have been commercialized as precoated plates because of the high cost of most chiral adsorbents and the difficulty to detect analytes on stationary phases showing a strong adsorbance during exposition to ...
LEPRI, LUCIANO, CINCINELLI, ALESSANDRA, DEL BUBBA, MASSIMO   +2 more
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Apparent and true enantioselectivity in enantioseparations

Chirality, 2000
The separation factor of two compounds in chromatography is the ratio of their equilibrium constants or retention factors. This parameter is universally employed to investigate their resolution and to optimize the experimental conditions of their analysis. In enantioseparations, the situation is more complex because there is a mixed retention mechanism.
G, Götmar, T, Fornstedt, G, Guiochon
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Cyclodextrin-Mediated Enantioseparations by Capillary Electrochromatography

2012
Immobilized cyclodextrin derivatives are used as chiral selectors in various modes of capillary electrochromatography (CEC). The present chapter describes three techniques in detail utilizing CDs in CEC: (1) open-tubular capillary electrochromatography (o-CEC), (2) packed capillary electrochromatography (p-CEC), and (3) monolithic capillary ...
Dorothee, Wistuba, Volker, Schurig
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Enantioseparation in microfluidic channels

Chemical Physics, 2010
Abstract Since the pharmaceutical or biological activity of enantiomers may be significantly different for the two chiral partner molecules, the separation of a racemic mixture into its component enantiomers represents a challenge of immense practical relevance.
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Chiral Mobile-Phase Additives in HPLC Enantioseparations

2012
High-performance liquid chromatography (HPLC) is one of the main separation techniques for chiral drugs. Among the chiral HPLC techniques available, the chiral mobile-phase additive (CMPA) technique is a valuable method for the direct enantioseparation of chiral chemical entities. In the CMPA method, the chiral selector is dissolved in the mobile phase
Lushan, Yu, Shengjia, Wang, Su, Zeng
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Preparative enantioseparations using supercritical fluid chromatography

Journal of Chromatography A, 2012
Chromatographic enantioseparation at the preparative scale is routinely used in pharmaceutical R&D to generate individual enantiomers. Supercritical fluid chromatography (SFC) has many advantages over liquid chromatography for these separations. These advantages include rapid screening of separation conditions at the analytical scale, more rapid ...
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Editorial Enantioseparations 2021

ELECTROPHORESIS, 2021
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