Results 61 to 70 of about 2,821 (224)

A Comparative Study of Coupled Preferential Crystallizers for the Efficient Resolution of Conglomerate-Forming Enantiomers

Pharmaceutics, 2017
The separation of enantiomers is of great importance due to their possible differences in therapeutic properties. Preferential crystallization in various configurations of coupled batch crystallizers is used as an attractive means to separate the ...
Aniruddha Majumder, Zoltan K. Nagy
doaj   +1 more source

A Design of Experiments‐Based Chiral HPLC Method for the Quantification of Talazoparib and Enantiomeric Purity Determination in Pharmaceutical Formulations

Chirality, Volume 38, Issue 4, April 2026.
A design of experiments–based chiral HPLC method was developed for the enantiomeric separation and quantification of talazoparib in pharmaceutical formulations. Efficient resolution of the enantiomers (RS > 7) was achieved within 12 min. The method was validated and successfully applied to tablet analysis, and its environmental sustainability was ...
Sakine Atila Karaca, Sona Aliyeva, Duygu Yeniceli   +2 more
wiley   +1 more source

Chiral Stationary Phases and their Relationship with Enantiomer Structures in Enantioseparation Research of Analytical Laboratory

, 2017
Chiral stationary phases (CSPs) and molecular structure of enantiomers are two independent but related aspects in enantioseparation, which are discussed on the basis of the experimental data from the previous study.
Shun Yao
core   +1 more source

Enantioseparation by Sonochromatography

Bulletin of the Korean Chemical Society, 2006
Although chiral separation has been one of the main topics of chromatographic practice for over twenty-five years, it still presents many difficulties. In this work, the ultrasonic dependence of chiral resolution was investigated at various temperatures to improve resolution and reduce analysis time.
openaire   +2 more sources

Enantioseparation by Dual-flow Countercurrent Extraction: Its Application to the Enantioseparation of (.+-.)-Propranolol.

Chemical and Pharmaceutical Bulletin, 1996
Enantioseparation of (±)-propranolol has been demonstrated by countercurrent extraction with a two-phase system composed of a chloroform solution of didodecyl L-tartrate (100mM) and an acetate buffer (50mM, pH 4.4) containing boric acid (100mM). The free base of (±)-propranolol (1.6g) was dissolved in the aqueous phase and extracted five times by means
ABE, Yoshiohiro, SHOJI, Tomoko, FUKUI, Shikie, SASAMOTO, Maki, NISHIZAWA, Hideyuki   +4 more
openaire   +2 more sources

Multiple‐Use Microplate Assay for Submicromolar Ultra High‐Throughput Separation of Amines Based on their Degree of Substitution

ChemistryOpen, Volume 15, Issue 4, April 2026.
A reusable microplate platform for ultra‐high‐throughput, submicromolar separation of protonated amines – including alkyl‐, aryl‐, and aralkyl‐types – using a tris(pyridino)‐crown ether selector was introduced; the method enables rapid, zero‐energy, parallel purification fully compatible with automated synthesis workflows.
Panna Vezse, Tünde Tóth, Péter Huszthy, Ádám Golcs   +3 more
wiley   +1 more source

Enantioselective Determination of Amphetamine‐Type Stimulants in Environmental Waters Using SPE and CE–MS/MS

ELECTROPHORESIS, Volume 47, Issue 3, Page 250-260, March 2026.
ABSTRACT The growing concern over drug abuse, particularly involving amphetamine‐type substances (ATS), has led to their monitoring in environmental waters. These chiral compounds, commonly found in river water and wastewater treatment plant (WWTP) effluents, require analytical methods capable of enantiomeric discrimination, as their enantiomers can ...
Pol Clivillé‐Cabré, Francesc Borrull, Carme Aguilar, Marta Calull   +3 more
wiley   +1 more source

Evaluation and comparison of N-cycloalkylformylated chitosan bis(arylcarbamate)s as chiral selectors for enantioseparation

, 2017
In order to systematically investigate the structural dependence on the properties of N-cycloalkyl-formylated chitosan bis(arylcarbamate)s, 3,5-dimethylphenylcarbamates of N-cyclopropylformylated, N-cyclobutylformylated, N-cyclopentylformylated and N ...
Zheng-Wu Bai, Tang, Sheng, Ke-Qin Fu, Bai, Zheng-Wu, Shao-Hua Huang, Huang, Shao-Hua, Chen, Wei, Fu, Ke-Qin, Liu, Jian-De, Xiao-Chen Wang, Jian-De Liu, Sheng Tang, Fei Yang, Wei Chen, Wang, Xiao-Chen, Yang, Fei   +15 more
core   +1 more source

Isolation, Characterization, and Stability Assessment of Pure Enantiomers of Cathinone Derivatives via Semi-Preparative HPLC-UV Using a Phenomenex Lux^® 5 Column

Molecules
In addition to well-known traditional synthetic illicit drugs like cocaine, amphetamines, and heroin, an increasing number of new psychoactive substances (NPS) are appearing on the global drug market.
Stefanie Handl, Katrin Stelzeneder, Annaluna Ravelli, Martin G. Schmid   +3 more
doaj   +1 more source

Designing a Green Chiral High‐Performance Liquid Chromatography Method: Proof‐of‐Concept with Crizotinib

Chemistry–Methods, Volume 6, Issue 2, February 2026.
A sustainable HPLC approach was developed for the enantioseparation of crizotinib using polysaccharide‐based chiral stationary phases under polar‐organic and reversed‐phase conditions. Experimental‐design optimization and greenness/whiteness assessment (AGREE, Eco‐Scale, Complex MoGAPI, AMGS, and RGB‐fast) identified an ethanol–water system as the most
Ali Mhammad, Gergely Dombi, Máté Dobó, Eliza Tóth, Gergely Molnár, Arash Mirzahosseini, Zoltán‐István Szabó, Gergő Tóth   +7 more
wiley   +1 more source