Results 1 to 10 of about 75,080 (214)

Liraglutide Attenuates Disease Severity in Experimental Autoimmune Encephalomyelitis by Modulating Splenic T Helper Cell Subsets [PDF]

Brain and Behavior
Objective To investigate the therapeutic effects of liraglutide, a glucagon‐like peptide‐1 receptor agonist, on clinical progression and splenic T‐cell subsets in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis ...
Shuang Song, Bin Li, Ruoyi Guo, Yi Zhou, Yumei Xue, Li Guo   +5 more
doaj   +2 more sources

Macrophage-targeted PEGylated liposomes ameliorate experimental autoimmune encephalomyelitis [PDF]

Frontiers in Immunology
Macrophages are the predominant immune cell type found in active multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) lesions, where they contribute to demyelination and axonal damage. Depending on the lesion stage, these cells can
Alexander Muselman, Lewis W. Yu, Khoa D. Nguyen, Mohammed Inayathullah, Qiang Liu, Kyle D. Brewer, Andrey V. Malkovskiy, Jayakumar Rajadas, Jayakumar Rajadas, Edgar G. Engleman, Edgar G. Engleman   +10 more
doaj   +2 more sources

RETRACTED: Haghmorad et al. Oral Administration of Myelin Oligodendrocyte Glycoprotein Attenuates Experimental Autoimmune Encephalomyelitis through Induction of Th2/Treg Cells and Suppression of Th1/Th17 Immune Responses. Curr. Issues Mol. Biol. 2022, 44, 5728–5740 [PDF]

Current Issues in Molecular Biology
The journal retracts the article “Oral Administration of Myelin Oligodendrocyte Glycoprotein Attenuates Experimental Autoimmune Encephalomyelitis through Induction of Th2/Treg Cells and Suppression of Th1/Th17 Immune Responses” [...]
Dariush Haghmorad, Bahman Yousefi, Majid Eslami, Ali Rashidy-Pour, Mahdieh Tarahomi, Maryam Jadid Tavaf, Azita Soltanmohammadi, Simin Zargarani, Aleksandr Kamyshnyi, Valentyn Oksenych   +9 more
doaj   +2 more sources

B cell-specific METTL3 depletion exacerbates experimental autoimmune encephalomyelitis [PDF]

Cellular and Molecular Life Sciences
N6-methyladenosine (m6A), the most prevalent RNA modification, plays a pivotal role in regulating mRNA metabolism and cellular processes such as immune responses.
Xuzhong Pei, Xiying Wang, Jie Ding, Haojun Yu, Chunran Xue, Chong Xie, Yi Chen, Xinyu Lin, Hong Yang, Yangtai Guan   +9 more
doaj   +2 more sources

Evaluation of methods of modeling and formation of experimental allergic encephalomyelitis [PDF]

Research Results in Pharmacology, 2022
Introduction: Experimental autoimmune (allergic) encephalomyelitis (EAE) induced by intradermal injection of homogenate of the brain, spinal cord and peripheral nerve with Freund’s stimulator, refers to a true autoimmune disease of the nervous system.
Oleksandr O. Nefodov, Igor F. Belenichev, Mykola P. Fedchenko, Olena O. Popazova, Victor P. Ryzhenko, Oksana V. Morozova   +5 more
doaj   +3 more sources

Genetic Background Can Result in a Marked or Minimal Effect of Gene Knockout (GPR55 and CB2 Receptor) in Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis [PDF]

, 2013
PMCID ...
A Compston, A Shetty, A Zimmer, AC Howlett, AE Bygrave, C Bolton, C Delarasse, C Delarasse, C Teuscher, Carolyn Tanner, CS Wu, CS Wu, D Baker, D Baker, D Baker, D Baker, D Baker, D Baker, D Baker, D McHugh, David Baker, David L. Selwood, DL Smith-Bouvier, E de Lago, E Kozela, E Montero, E Zurita, F Docagne, F Wu, G Disanto, G Musumeci, G Paltser, G Pryce, G Pryce, G Wotherspoon, Gareth Pryce, Gavin Giovannoni, Gregory J. Michael, H Kataoka, HM Vesterinen, I Mendel, J Corey-Bloom, J Karlsson, J Palazuelos, JA Encinas, JB Davis, JH Slingsby, JK O'Neill, JL Croxford, JL Croxford, JM Coquet, JP Zajicek, K Li, K Maresz, KM Spach, L Cristino, LM Olsson, LS Whyte, M Sundvall, M Webb, MF Festing, NA Balenga, NE Buckley, O Ofek, PC Staton, PD Fillmore, PM Hoi, RA Ross, RA Ross, RC Axtell, RG Pertwee, RG Pertwee, RJ Butterfield, Roberto Furlan, RS Graves, Ruth A. Ross, S Al-Izki, S Al-Izki, S Amor, S Amor, S Amor, S Katona, S Levine, S Levine, S Rossi, S Saadoun, Samuel J. Jackson, SC Landis, SJ Allen, Sofia Sisay, V Devonshire, Y Okuda, ZY Lou   +92 more
core   +12 more sources

MicroRNAs as disease progression biomarkers and therapeutic targets in experimental autoimmune encephalomyelitis model of multiple sclerosis

Neural Regeneration Research, 2020
Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain, spinal cord and optic nerve leading to demyelination.
Bridget Martinez, Philip V Peplow
doaj   +1 more source

Should mast cells be considered therapeutic targets in multiple sclerosis?

Neural Regeneration Research, 2020
Mast cells are immune cells of the myeloid lineage that are found throughout the body, including the central nervous system. They perform many functions associated with innate and specific immunity, angiogenesis, and vascular homeostasis.
Karen Henriette Pinke, Sofia Fernanda Gonçalves Zorzella-Pezavento, Vanessa Soares Lara, Alexandrina Sartori   +3 more
doaj   +1 more source

Amelioration of experimental autoimmune encephalomyelitis by anatabine. [PDF]

PLoS ONE, 2013
Anatabine, a naturally occurring alkaloid, is becoming a commonly used human food supplement, taken for its claimed anti-inflammatory properties although this has not yet been reported in human clinical trials.
Daniel Paris, David Beaulieu-Abdelahad, Myles Mullan, Ghania Ait-Ghezala, Venkat Mathura, Corbin Bachmeier, Fiona Crawford, Michael J Mullan   +7 more
doaj   +1 more source

Contribution of pannexin1 to experimental autoimmune encephalomyelitis. [PDF]

PLoS ONE, 2013
Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. We tested the hypothesis that
Sarah E Lutz, Estibaliz González-Fernández, Juan Carlos Chara Ventura, Alberto Pérez-Samartín, Leonid Tarassishin, Hiromitsu Negoro, Naman K Patel, Sylvia O Suadicani, Sunhee C Lee, Carlos Matute, Eliana Scemes   +10 more
doaj   +1 more source