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Nature Reviews Disease Primers, 2022 Hepatic encephalopathy (HE) is a prognostically relevant neuropsychiatric syndrome that occurs in the course of acute or chronic liver disease. Besides ascites and variceal bleeding, it is the most serious complication of decompensated liver cirrhosis.
Dieter Häussinger +11 more
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DMW - Deutsche Medizinische Wochenschrift, 2001 Hepatic encephalopathy (HE) is a reversible syndrome of impaired brain function occurring in patients with advanced liver diseases. The precise pathophysiology of HE is still under discussion; the leading hypothesis focus on the role of neurotoxins, impaired neurotransmission due to metabolic changes in liver failure, changes in brain energy metabolism,
Srinivasan Dasarathy, Kevin D. Mullen
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International Journal of Clinical Practice, 2023 Objective. COVID-19 has evolved into a major global public health event. The number of people reporting insomnia is growing exponentially during the pandemic.
Hai-Tao Jin +7 more
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Mediators of Inflammation, 2022 The endothelial dysfunction, associated with inflammation and vascular permeability, remains the key event in the pathogenesis of cerebral ischemic stroke. Angiogenesis is essential for neuroprotection and neural repair following stroke.
Yongdan Cun +8 more
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Applied Bionics and Biomechanics, 2022 Carotid atherosclerotic plaque (CAP) is one of the leading causes of cerebral infarction. Western medicine usually uses lipid-lowering drugs to stabilize plaques. Currently, studies reporting on drugs that can reduce plaques are lacking.
Wentong Wang, Zhuli Liu, Yongxiong Wu
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PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease
Cell Death and Disease, 2022 A persistent accumulation of damaged mitochondria is part of prion disease pathogenesis. Normally, damaged mitochondria are cleared via a major pathway that involves the E3 ubiquitin ligase parkin and PTEN-induced kinase 1 (PINK1) that together initiate ...
Jie Li +12 more
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Frontiers in Surgery, 2021 Contrast-induced encephalopathy (CIE) is a rare complication of endovascular treatment and is extensively reported as a transient and reversible phenomenon.
Ying Zhang +8 more
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Chinese Medicine, 2022 Background Parkinson’s disease (PD) is a progressive neurodegenerative disease common in aged populations. Classified by Hoehn & Yahr stages, patients are often divided into mild/early stage, moderate/middle stage, and advanced/late stage.
Yuqing Hu +5 more
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MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis
Genes and Environment, 2021 Background Previous studies have shown the effect of MTHFR A1298C gene polymorphism on stroke risk. But the results of published studies remained inconclusive and controversial.
Xiaobo Dong +5 more
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Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration
Scientific Reports, 2021 Wilson's Disease (WD), an ATP7B-mutated inherited disease that affects copper transport, is characterised by liver and nervous system manifestations. Long non-coding (ln-c) RNAs are widely involved in almost all physiological and pathological processes ...
Juan Zhang +8 more
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