Results 51 to 60 of about 453,156 (401)

Sepsis-associated encephalopathy: a vicious cycle of immunosuppression

Journal of Neuroinflammation, 2020
Sepsis-associated encephalopathy (SAE) is commonly complicated by septic conditions, and is responsible for increased mortality and poor outcomes in septic patients.
C. Ren, R. Yao, Hui Zhang, Yong-wen Feng, Yong-ming Yao   +4 more
semanticscholar   +1 more source

Copper deposition in Wilson’s disease causes male fertility decline by impairing reproductive hormone release through inducing apoptosis and inhibiting ERK signal in hypothalamic-pituitary of mice

Frontiers in Endocrinology, 2022
Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism characterized by liver and central nervous system dysfunction. Considerable evidence suggests that infertility is also very common in male patients with WD, but the exact ...
Tingting Wang, Limin Wu, Qiuying Chen, Kuiyu Chen, Fang Tan, Jiabo Liu, Xiang Liu, Hui Han   +7 more
doaj   +1 more source

Validity of the 2014 traumatic encephalopathy syndrome criteria for CTE pathology

Alzheimer's & Dementia, 2021
Validity of the 2014 traumatic encephalopathy syndrome (TES) criteria, proposed to diagnose chronic traumatic encephalopathy (CTE) in life, has not been assessed.
Jesse B. Mez, M. Alosco, Daniel H. Daneshvar, Nicole Saltiel, Zachary H. Baucom, Bobak Abdolmohammadi, Madeline Uretsky, Raymond Nicks, Brett M. Martin, J. Palmisano, Christopher J. Nowinski, Philip H. Montenigro, Todd M. Solomon, Ian Mahar, Jonathan D. Cherry, Victor E. Alvarez, Brigid Dwyer, L. Goldstein, D. Katz, R. Cantu, N. Kowall, Yorghos Tripodis, B. Huber, T. Stein, R. Stern, A. Mckee   +25 more
semanticscholar   +1 more source

DNM1 encephalopathy: A new disease of vesicle fission. [PDF]

, 2017
ObjectiveTo evaluate the phenotypic spectrum caused by mutations in dynamin 1 (DNM1), encoding the presynaptic protein DNM1, and to investigate possible genotype-phenotype correlations and predicted functional consequences based on structural modeling ...
Campbell, Colleen A, Cervenka, Mackenzie C, Cilio, Maria R, Cohen, Julie S, Dlugos, Dennis J, Epi4K Consortium, EuroEPINOMICS-RES NLES Working Group, Fatemi, Ali, Helbig, Ingo, Helbig, Katherine L, Hernandez-Hernandez, Laura, Hollingsworth, Georgie, Huether, Robert, Joshi, Charuta N, Kaplan, Richard A, Kirsch, Heidi, Kolbe, Diana L, Lawson, John A, Littlejohn, Rebecca, Lourenço, Charles, Maher, Bridget, McClellan, Rebecca, McLean, Scott D, Muhle, Hiltrud, Møller, Rikke S, Neubauer, Bernd A, Nunes, Mark E, Palmer, Elizabeth, Pena, Sérgio DJ, Pendziwiat, Manuela, Sagawa, Yoshimi, Sarco, Dean P, Scheffer, Ingrid E, Shinde, Deepali N, Sisodiya, Sanjay M, Slavotinek, Anne, Stephani, Ulrich, von Spiczak, Sarah, Yuen, Amy   +38 more
core   +2 more sources

Sepsis-Associated Encephalopathy: From Delirium to Dementia?

Journal of Clinical Medicine, 2020
Sepsis is a major cause of death in intensive care units worldwide. The acute phase of sepsis is often accompanied by sepsis-associated encephalopathy, which is highly associated with increased mortality.
Ha-Yeun Chung, Jonathan Wickel, F. Brunkhorst, C. Geis   +3 more
semanticscholar   +1 more source

Brain dysfunction in COVID‐19 and CAR‐T therapy: cytokine storm‐associated encephalopathy

Annals of Clinical and Translational Neurology, 2021
Many neurological manifestations are associated with COVID‐19, including a distinct form of encephalopathy related to cytokine storm, the acute systemic inflammatory syndrome present in a subgroup of COVID‐19 patients.
Umberto Pensato, L. Muccioli, I. Cani, D. Janigro, P. Zinzani, M. Guarino, P. Cortelli, F. Bisulli   +7 more
semanticscholar   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Comprehensive analysis of the coding and non-coding RNA transcriptome expression profiles of hippocampus tissue in tx-J animal model of Wilson's disease

Scientific Reports, 2023
Wilson's disease (WD) is an autosomal recessive disorder with a genetic basis. The predominant non-motor symptom of WD is cognitive dysfunction, although the specific genetic regulatory mechanism remains unclear.
Dan Wang, Daojun Xie, Juan Zhang, Biao Cai, Bo Yang, Lei Zhou, Xiaofeng Huang   +6 more
doaj   +1 more source

Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie [PDF]

, 2010
With increased awareness of the diversity of transmissible spongiform encephalopathy (TSE) strains in the ruminant population, comes an appreciation of the need for improved methods of differential diagnosis. Exposure to bovine spongiform encephalopathy (
Bossers, A., Jacobs, J.G., Keulen, L.J.M., van, Langeveld, J.P.M., Sauer, M., Tang, Y.   +5 more
core   +2 more sources

Yi-nao-jie-yu Prescription Exerts a Positive Effect on Neurogenesis by Regulating Notch Signals in the Hippocampus of Post-stroke Depression Rats

Frontiers in Psychiatry, 2018
Post-stroke depression (PSD) is one of the most frequent complications of stroke. The Yi-nao-jie-yu prescription (YNJYP) is an herbal prescription widely used as a therapeutic agent against PSD in traditional Chinese medicine.
Huiling Tian, Xiaoli Li, Qisheng Tang, Wen Zhang, Qingmeng Li, Xinyue Sun, Ruizhen Zhao, Chongyang Ma, Haipeng Liu, Yushan Gao, Fei Han   +10 more
doaj   +1 more source