Results 51 to 60 of about 309,185 (347)

Hepatic Encephalopathy: Definition, Clinical Grading and Diagnostic Principles

Drugs, 2019
In general, hepatic encephalopathy (HE) is defined as a brain dysfunction caused by liver insufficiency and/or portal-systemic blood shunting. This article relates to the so-called type C HE: that is, HE in patients with liver cirrhosis.
K. Weissenborn
semanticscholar   +1 more source

Astragaloside IV Treats Parkinson’s Disease by Regulating the Proliferation and Differentiation of NSCs through the SHH–Nurr1 Pathway

Stem Cells International
Recently, there has been a surge of interest in enhancing the differentiation of neural stem cells (NSCs) and supplementing dopamine neurons as a potential treatment for Parkinson’s disease, the second most prevalent neurodegenerative disorder.
Zicong Wu, Jianing Zhang, Han Gao, Wentao Li   +3 more
doaj   +1 more source

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

FEBS Letters, EarlyView.
We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio, Sofia Lövestam, Michael A. Metrick II, Thomas Löhr, Peifeng Xu, Nicholas C. T. Gallagher, Bernardino Ghetti, Byron Caughey, Sjors H. W. Scheres, Michele Vendruscolo   +9 more
wiley   +1 more source

Hypertensive encephalopathy. [PDF]

Stroke, 1982
Hypertensive encephalopathy is examined in the context of an acute cerebral episode precipitated by sudden, severe hypertension. Since it is a medical emergency and responds to prompt and vigorous treatment, the author discusses its clinical manifestations, diagnosis, pathology, pathogenesis, and treatment.
openaire   +3 more sources

Exploring if Longitudinal Changes on PET Imaging Can Serve as a Biomarker for Stiff Person Syndrome Spectrum Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify metabolic patterns in the brain and musculoskeletal system of stiff person syndrome spectrum disorders (SPSD) patients over time using PET imaging and evaluate the impact of immune therapy on metabolic activity as a surrogate for treatment response.
Munther M. Queisi, Samantha N. Roman, Mohammad S. Sadaghiani, Lilja B. Solnes, Scott D. Newsome   +4 more
wiley   +1 more source

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome

Annals of Neurology, 2020
SCN8A encephalopathy is a developmental and epileptic encephalopathy (DEE) caused by de novo gain‐of‐function mutations of sodium channel Nav1.6 that result in neuronal hyperactivity.
Guy M. Lenk, P. Jafar‐nejad, Sophie F. Hill, Lucas D. Huffman, Corrine Smolen, Jacy L. Wagnon, Hayley Petit, Wenxi Yu, Julie Ziobro, K. Bhatia, J. Parent, R. Giger, F. Rigo, M. Meisler   +13 more
semanticscholar   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Characteristics of Cerebral Palsy in the Midwestern US

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebral palsy (CP) is the most common lifelong motor disability worldwide. Yet, data is limited on how CP manifests in the US. Our objective was to characterize and determine factors affecting functional outcomes in a large population of young people with CP in the Midwestern US.
Susie Kim, Kelsey Steffen, Lauren Gottschalk‐Henneberry, Jennifer Miros, Amy Robichaux‐Viehoever, Karen Taca, Bhooma R. Aravamuthan   +6 more
wiley   +1 more source

Prevalence of diabetes in the USA from the perspective of demographic characteristics, physical indicators and living habits based on NHANES 2009-2018

Frontiers in Endocrinology, 2023
ObjectiveTo determine differences in DM in the U.S. population according to demographic characteristics, physical indicators and living habits.Methods23 546 participants in the 2009 to 2018 National Health and Nutrition Examination Survey (NHANES) who ...
Ling Fang, Huafang Sheng, Yingying Tan, Qi Zhang   +3 more
doaj   +1 more source

Wernicke’s encephalopathy [PDF]

Neurology, 2002
A 57-year-old alcoholic man was admitted for nausea, vomiting, and diarrhea for 1 month, and confusion, imbalance, and auditory and visual hallucinations for 1 week. His daughter …
A. Moghekar, David S. Zee, P. Ramulu, V. Chaudhry, S. G. Reich   +4 more
openaire   +3 more sources