Results 41 to 50 of about 1,264,841 (338)

Polska wieś jako szara strefa. Sołtysi na poziomie mezo w Generalnym Gubernatorstwie 1939–1945

Zagłada Żydów, 2023
Artykuł skupia się na instytucjach zakorzenionych w polskim życiu wiejskim, które Niemcy włączyli jako najniższy poziom administracyjny w okupowanej Polsce w latach 1939–1945. Autor określa te instytucje jako kluczowe elementy poziomu mezo wpływające na
Tomasz Frydel
doaj   +1 more source

The Locus Ceruleus in PTSD [PDF]

, 2009
NO ABSTRACT: This is 750 word encyclopedia ...
Bracha, Dr. H. Stefan, Lenze, Stacy M., Macy, Caitlin, Shelton, Jessica M., Tsang-Mui-Chung, Michelle   +4 more
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Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Anapedia – An Open Web-based Encyclopedia for Indonesian Children

Journal of Information Systems Engineering and Business Intelligence, 2019
Background: The limited number of web and child applications becomes a challenge especially providing web or education app that can be a source of information referral to help the school task, especially for the needs of children in Indonesia. Objective:
Nur Hayatin, Rizky Ade Mahendra, Dwi Arif Al-mubarok, Ahmad Dhana Renomi, Elbert Setiadharma, Adhi Bagus Setiawan, Tri Fidriyan Arya, Farid Dadhee, Fadil Ramadhan, Sandy Young, Ahmad Al Ghivani   +10 more
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Pline l’Ancien a-t-il cru à ses mythes ?

Pallas, 2009
Book VII of Pliny the Elder’ s Natural History, devoted to man, ends on a curious catalogue of inventors and inventions. It is on the treatment of myth in that inventory that we intend to ponder.
Valérie Naas
doaj   +1 more source

Mediterranean Region Encyclopedia

Проблемы постсоветского пространства, 2021
The Mediterranean Sea consisting of numerous seas is enclosed by three continents — Europe, Asia and Africa. It is a specific phenomenon in terms of geography, oceanology and world history.
A. V. Semenov, I. S. Zonn
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Atomismus [PDF]

, 2005
Encyclopedia article briefly summarizing the history of atomism from antiquity to ...
Johnson, Monte
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