Results 101 to 110 of about 170,038,675 (262)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Correction: Palliative care symptoms, concerns and well-being of older people with frailty and complex care needs upon hospital discharge: a cross-sectional study

BMC Palliative Care, 2022
Kim de Nooijer, Nele Van Den Noortgate, Peter Pype, Lieve Van den Block, Lara Pivodic   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

End-of-Life Care

, 2020
End-of-Life ...
Melissa Bloomer (13084395)
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluation of the experience led commissioning in end of life care project

, 2012
A pilot Experience Led Commissioning (ELC) for an end of life care project was evaluated independently by the University of Westminster. Overall, the evaluation uncovered favourable reports on the delivery of ELC.
Ridge, Damien T., Cheshire, A.
core  

Beliefs, death, anxiety, denial, and treatment preferences in end-of-life care: a comparison of social work students, community residents, and medical students.

, 2005
This study examined cultural and religious beliefs, death anxiety, denial, and medical treatment preferences in end-of-life care in a sample of social work students, community residents, and medical students in a mid-western city of 49,000.
Chan, CL, Perry, DC, Reese, DJ, Schlinger, JM, Wiersgalla, D   +4 more
core   +1 more source

Living Memory Home for Dementia Care Pairs (LMH-4-DCP): study protocol for a pilot randomized trial of a web-based reminiscence intervention for family caregivers and persons with dementia

Pilot and Feasibility Studies
Background Family caregivers provide most of the emotional, physical, and logistical support for people living with Alzheimer’s disease and related dementias (ADRD).
Francesca B. Falzarano, Annabelle Greenfield, Sydney C. Saviano, Sindhu Kolla, Sosi Korian, Francesco Osso, Joseph Miller, Paul K. Maciejewski, Heather E. Whitson, Holly G. Prigerson   +9 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Practice development in end of life home care [PDF]

, 2015
This keynote presentation for the German Patient Safety in Palliative Home Care Round Table Discussion and Conference at Berlin Charité Medical University (8th -11th April, 2015) outlines the principles of practice development and provides published ...
O'Connor, S.
core