Results 91 to 100 of about 170,038,675 (262)
Trials, 2019 Background Critical illness increases the risk for poor mental health outcomes among both patients and their informal caregivers, especially their surrogate decision-makers.
Holly G. Prigerson +13 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
BMC Medical Ethics, 2019 Background Notwithstanding fears of overly permissive approaches and related pleas to refuse euthanasia for psychological suffering, some Belgian hospitals have declared that such requests could be admissible.
M. Verhofstadt +4 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Anticipatory prescribing in end-of-life care [PDF]
, 2014 Anticipatory prescriptions are often issued by GPs for patients nearing the end of life, ahead of symptoms they may experience. These prescriptions are often activated by nurses.
Seymour, Jane E. +6 more
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Care at the end of life: how policy and the law support practice [PDF]
, 2013 The End of Life Care Strategy was introduced in an attempt to achieve\ud a high standard of care for patients nearing the end of life and to\ud improve carer experience.
Brown, Michelle, Vaughan, Carol
core
Evaluating complex interventions in end of life care : the MORECare statement on good practice generated by a synthesis of transparent expert consultations and systematic reviews [PDF]
, 2013 Despite being a core business of medicine, end of life care (EoLC) is neglected. It is hampered by research that is difficult to conduct with no common standards.
Gunn Grande +54 more
core +4 more sources
How to achieve the desired outcomes of advance care planning in nursing homes: a theory of change
BMC Geriatrics, 2018 Background Advance care planning (ACP) has been identified as particularly relevant for nursing home residents, but it remains unclear how or under what circumstances ACP works and can best be implemented in such settings.
J. Gilissen +6 more
doaj +1 more source