Results 81 to 90 of about 2,185,843 (265)

Uncovering the end-of-life trajectories of older people with serious chronic illnesses: study protocol for the quantitative longitudinal study of the TRAJECT project

BMJ Open
Introduction Older people who die with a serious chronic disease are at risk of experiencing extended periods (ie, months or years) of fluctuations and deterioration in their health and well-being.
Lieve Van den Block, Aline De Vleminck, Lara Pivodic, Nele Van Den Noortgate, Eline Naert, Lore Decoster, Casper Van den Bossche, Khyati Tripathi   +7 more
doaj   +1 more source

When is hastened death considered suicide? A systematically conducted literature review about palliative care professionals’ experiences where assisted dying is legal

BMC Palliative Care, 2019
Background Laws allowing assisted suicide and euthanasia have been implemented in many locations around the world but some individuals suffering with terminal illness receiving palliative care services are hastening death or die by suicide without ...
Sheri Mila Gerson, Amanda Bingley, Nancy Preston, Anne Grinyer   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience (EMPOWER) among Surrogate Decision-Makers of ICU Patients: study protocol for a randomized controlled trial

Trials, 2019
Background Critical illness increases the risk for poor mental health outcomes among both patients and their informal caregivers, especially their surrogate decision-makers.
Holly G. Prigerson, Martin Viola, Chris R. Brewin, Christopher Cox, Daniel Ouyang, Madeline Rogers, Cynthia X. Pan, Shayna Rabin, Jiehui Xu, Susan Vaughan, Janna S. Gordon-Elliot, David Berlin, Lindsay Lief, Wendy G. Lichtenthal   +13 more
doaj   +1 more source

Flourishing at the end of life

Theoretical Medicine and Bioethics
AbstractFlourishing is an increasingly common construct employed in the study of human wellbeing. But its appropriateness as a framework of wellbeing at certain stages of life is contested. In this paper, we consider to what extent it is possible for someone to flourish at the end of life.
Xavier Symons, John Rhee, Anthony Tanous, Tracy Balboni, Tyler J. VanderWeele   +4 more
openaire   +2 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Ghent University Hospital’s protocol regarding the procedure concerning euthanasia and psychological suffering

BMC Medical Ethics, 2019
Background Notwithstanding fears of overly permissive approaches and related pleas to refuse euthanasia for psychological suffering, some Belgian hospitals have declared that such requests could be admissible.
M. Verhofstadt, K. Audenaert, K. Van Assche, S. Sterckx, K. Chambaere   +4 more
doaj   +1 more source

The “End of Life” Stage

The Primary Care Companion For CNS Disorders, 2012
One of the more important books that I have read talks about the different segments of one's life.1 The concept of life stage has been useful for treating a variety of people at different times of their lives. When puberty or the calendar ushers in adolescence, a new life stage begins.
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source