Results 51 to 60 of about 2,185,843 (265)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Experiences with implementing advance care planning (ACP-GP) in Belgian general practice in the context of a cluster RCT: a process evaluation using the RE-AIM framework

BMC Primary Care
Background General practice is often recommended as an ideal setting to initiate advance care planning (ACP), but uptake of ACP in this setting is low. ACP-GP is a complex intervention to facilitate ACP for patients with chronic, life-limiting illness in
Julie Stevens, Anne-Lore Scherrens, Peter Pype, Luc Deliens, Aline De Vleminck, Koen Pardon   +5 more
doaj   +1 more source

Disseminating research findings using a massive online open course for maximising impact and developing recommendations for practice

BMC Palliative Care, 2020
Background Developing recommendations for how we deliver healthcare is often left to leading experts in a field. Findings from the Integrated Palliative Care in cancer and chronic conditions (InSup-C) study, which aimed to identify best practice in ...
Nancy Preston, Jeroen Hasselaar, Sean Hughes, Alex Kaley, Lisa Linge-Dahl, Ildiko Radvanyi, Phil Tubman, Karen Van Beek, Sandra Varey, Sheila Payne   +9 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

End-of-Life Decisions: Ethics, Cultural Norms, and Resource Management

The Annals of African Surgery, 2012
The technological advances of medicine in recent decades have made it possible to extend the life of critically ill patients even in resource poor countries in Sub-Saharan Africa.
Adwok JA, Minelli M
doaj  

Timely short-term specialised palliative home care for older people with frailty and their family: a mixed-methods pilot randomised controlled trial and process evaluation

BMJ Open
Objective The primary study aims were to evaluate the implementation, mechanisms and context of a timely short-term specialised palliative care intervention for older people with frailty (Frailty+ intervention) as well as to assess the feasibility of a ...
, Lieve Van den Block, Kim de Nooijer, Lara Pivodic, Peter Pype, Nele Van Den Noortgate, Rose Miranda, Kim Eecloo, Stefanie De Buyser, Aurelie Joos, Katlijn Van Mulders   +10 more
doaj   +1 more source

End of Life Research [PDF]

Journal of Aging Research, 2011
Changes in medical technology have transformed the end of life not only in length but in complexity. The final phase of life poses challenges for patients, families, healthcare providers, and policy decision-makers and encompasses a wide range of topics such as service delivery, health economics, family dynamics, medical decision-making, and advance ...
Laraine Winter, Helen K. Black, Brian Carpenter, Nancy A. Hodgson   +3 more
openaire   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Implementing the theory-based advance care planning ACP+ programme for nursing homes: study protocol for a cluster randomised controlled trial and process evaluation

BMC Palliative Care, 2020
Background Research has highlighted the need for improving the implementation of advance care planning (ACP) in nursing homes. We developed a theory-based multicomponent ACP intervention (the ACP+ programme) aimed at supporting nursing home staff with ...
Joni Gilissen, Lara Pivodic, Annelien Wendrich-van Dael, Chris Gastmans, Robert Vander Stichele, Yvonne Engels, Myrra Vernooij-Dassen, Luc Deliens, Lieve Van den Block   +8 more
doaj   +1 more source