Results 111 to 120 of about 3,892,232 (280)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Explaining Diversities in Age-Specific Life Expectancies and Values of Life Saving: A Numerical Analysis [PDF]
Little attempt has been made so far to quantify the extent to which individual willingness to spend on life protection may account for the observed trends and diversities in agespecific life expectancies across individuals and over time. We address these
Isaac Ehrlich, Yong Yin
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Space Station Technology Summary [PDF]
The completion of the Space Station Propulsion Advanced Technology Programs established an in-depth data base for the baseline gaseous oxygen/gaseous hydrogen thruster, the waste gas resistojet, and the associated system operations.
Braunscheidel, E. +4 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Growing up with HIV: The experiences of young people living with HIV since birth in the UK [PDF]
, 2008 About the book: This book draws together a range of both classic and newly commissioned pieces on the multidisciplinary study of death and dying. Organized into five parts, the book begins with a general exploration of the meaning of death, before ...
Dorrell, Judith +3 more
core
Joint Energy Efficient and QoS-aware Path Allocation and VNF Placement for Service Function Chaining
, 2018 Service Function Chaining (SFC) allows the forwarding of a traffic flow along a chain of Virtual Network Functions (VNFs, e.g., IDS, firewall, and NAT).
Akbari, Behzad +4 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
McGill Journal of MedicineMcGill Journal of Medicine (MJM) Podcast Series, MJM MedTalks, interviews members of the medical and health sciences community from McGill, and beyond to gain insights into their careers, research, advocacy, and more.
Maryia Samuel +7 more
doaj
End-of-Life Issues in the Era of the COVID-19 Pandemic. [PDF]
Hanguk Hosupisu Wanhwa Uiryo Hakhoe Chi, 2020 Ghosh D, Gupta B.
europepmc +1 more source