Results 171 to 180 of about 7,340,393 (314)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
End In der Welt voran Bekannteste Marke für feinste Zuckerwaren,Waffeln u. Konfekte
END IN DER WELT VORAN BEKANNTESTE MARKE FÜR FEINSTE ZUCKERWAREN,WAFFELN U. KONFEKTE End In der Welt voran Bekannteste Marke für feinste Zuckerwaren,Waffeln u. Konfekte ( -
Wilh.Jentesch,Dresden, End
core
End-to-End Modeling for Abstractive Speech Summarization
In our increasingly interconnected world, where speech remains the most intuitive and natural form of communication, spoken language processing systems face a crucial challenge: they must do more than just categorize speech, they need to truly ...
Roshan Sharma (5968718)
core +1 more source
A cloud-edge-end collaborative intelligent caching method based on incremental federated learning algorithms. [PDF]
PLoS OneHuang X, Jin L, Lin K, Wu W, Lin Z.
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
An investigation of end user development success
, 2002 User development of applications provides end users with an alternative to the traditional process of systems development by allowing them to solve job related problems by developing their own software applications.
McGill, Tanya Jane
core
Patient-Specific In Silico Prediction of Outcomes of Partial Continuous-Flow LVAD Treatment in Peripartum Cardiomyopathy. [PDF]
Int J Numer Method Biomed EngNagawa J +8 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Validation of pregnancy date estimation from outpatient electronic health record data. [PDF]
JAMIA OpenLyon-Scott K +6 more
europepmc +1 more source