Results 151 to 160 of about 7,379,857 (314)
An investigation of end user development success [PDF]
, 2002 User development of applications provides end users with an alternative to the traditional process of systems development by allowing them to solve job related problems by developing their own software applications.
McGill, Tanya Jane
core +1 more source
Between bullets and outbreaks: epidemic control in Sudan’s forgotten war
Conflict and HealthTwo years into Sudan’s prolonged war, the collapse of health systems has fueled multiple concurrent epidemics, triggering a complex humanitarian emergency with regional spillover risks.
Salma Ibrahim Mohammed Adam +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Letter to all state employees regarding end of governorship [PDF]
, 1987 Atiyeh's letter to all state employees regarding the end of his term in office thanking them for their ...
Atiyeh, Victor
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
End-to-end multimodal 16-day hatching eggs classification [PDF]
, 2019 Sixteen-day hatching eggs are divided into fertile eggs, waste eggs, and recovered eggs. Because different categoriesmayhave the same characteristics, they are difficult to classify. Fewexisting algorithms can successfully solve this problem. To this end,
Zhen Peng (539724) +3 more
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source