Results 141 to 150 of about 7,340,393 (314)
Between bullets and outbreaks: epidemic control in Sudan’s forgotten war
Conflict and HealthTwo years into Sudan’s prolonged war, the collapse of health systems has fueled multiple concurrent epidemics, triggering a complex humanitarian emergency with regional spillover risks.
Salma Ibrahim Mohammed Adam +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
West End House (Boston, Mass.) records, 1909, 1981.
, 1909 Materials in this collection include an edition of the West End House Forum from 1909, Vol. 1, Nos. 5-6. This contains editorials, House news, and other writings pertaining to or of interest to The West End House and its members.
West End House (Boston, Mass.)
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Letter to all state employees regarding end of governorship [PDF]
, 1987 Atiyeh's letter to all state employees regarding the end of his term in office thanking them for their ...
Atiyeh, Victor
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Rethinking the Design of the Internet: End to End Arguements vs. the Brave New World
, 2000 This paper looks at the Internet and the changing set of requirements for the Internet that are 8oriented towards the consumer, and used for a wider set of purposes.
Clark, David, Blumenthal, Marjory
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source