Results 121 to 130 of about 7,379,857 (314)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
West End House (Boston, Mass.) records, 1909, 1981. [PDF]
, 1909 Materials in this collection include an edition of the West End House Forum from 1909, Vol. 1, Nos. 5-6. This contains editorials, House news, and other writings pertaining to or of interest to The West End House and its members.
West End House (Boston, Mass.)
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Rethinking the Design of the Internet: End to End Arguements vs. the Brave New World [PDF]
, 2000 This paper looks at the Internet and the changing set of requirements for the Internet that are 8oriented towards the consumer, and used for a wider set of purposes.
Clark, David, Blumenthal, Marjory
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Design of automated End-to-End tests for web applications: framework analysis and implementation [PDF]
reservedQuesto documento descrive il lavoro svolto durante il periodo di stage presso l'azienda Sanmarco Informatica S.p.A. Il tirocinio ha avuto come obiettivo principale la progettazione e lo sviluppo di un sistema di automazione dei test End-to-End ...
CAMPESE, MARTINA
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Clark's Mile-End Spool Cotton trade card [PDF]
, 1900 Dated ca. 1900, this trade card advertises Clark's Mile-End Spool Cotton thread used for sewing clothing. In the center of the card is a short poem in which Robins can agree on nothing other than Clark's Mile-End is "woman's greatest friend." The poem is
Clark's Mile-End Spool Cotton Company
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