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The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
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Journal of Dynamic Systems, Measurement, and Control, 1986
The path followed by a robotic manipulator is often defined by a sequence of Cartesian knots, i.e., position and orientation (location) of the end effector and the corresponding linear and angular velocity (speed) at each knot. The path location and speed in the interval between knots are not specified.
Goldenberg, A. A., Lawrence, D. L.
openaire +2 more sources
The path followed by a robotic manipulator is often defined by a sequence of Cartesian knots, i.e., position and orientation (location) of the end effector and the corresponding linear and angular velocity (speed) at each knot. The path location and speed in the interval between knots are not specified.
Goldenberg, A. A., Lawrence, D. L.
openaire +2 more sources
SAE Technical Paper Series, 2009
<div class="htmlview paragraph">This paper presents an innovative, compact, autonomous and accurate solution for swaging aeronautical LGP collars on robots. Its rigid structure allows the application of clamping force that enables one-way assembly of aeronautical structures.
Guillaume Luc, Philippe Le Vacon
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<div class="htmlview paragraph">This paper presents an innovative, compact, autonomous and accurate solution for swaging aeronautical LGP collars on robots. Its rigid structure allows the application of clamping force that enables one-way assembly of aeronautical structures.
Guillaume Luc, Philippe Le Vacon
openaire +1 more source
2021
The efficiency and effectiveness of end-effectors greatly influence the overall performance of the robotic systems as they come into direct contact with the objects being manipulated by the robot. Considering the extensive need of robotic technologies for various labor-intensive tasks in agriculture, end-effectors for agricultural robots are required ...
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The efficiency and effectiveness of end-effectors greatly influence the overall performance of the robotic systems as they come into direct contact with the objects being manipulated by the robot. Considering the extensive need of robotic technologies for various labor-intensive tasks in agriculture, end-effectors for agricultural robots are required ...
openaire +1 more source
SAE Technical Paper Series, 2001
<div class="htmlview paragraph">Electroimpact developed an end effector for Airbus UK, Ltd. for use on a Kuka KR350 robot provided by Airbus UK. The end effector is referred to as the DDEE (Drill and Drive End Effector), and incorporates four main functions. The end effector pushes up on a wing panel with programmable pressure, drills a hole with
Ben Hempstead +3 more
openaire +1 more source
<div class="htmlview paragraph">Electroimpact developed an end effector for Airbus UK, Ltd. for use on a Kuka KR350 robot provided by Airbus UK. The end effector is referred to as the DDEE (Drill and Drive End Effector), and incorporates four main functions. The end effector pushes up on a wing panel with programmable pressure, drills a hole with
Ben Hempstead +3 more
openaire +1 more source
End-effector position-orientation measurement
IEEE Transactions on Robotics and Automation, 1999A low-cost device is presented for noncontact measurement of robot position and orientation. It consists of an optical sensor and three laser scanners. The sensor is attached to the end-effector while the laser scanners cast light planes to trace the sensor movement. The device measures equations of the light planes from which end-effector position and
null Jing Yuan, S.L. Yu
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