Results 71 to 80 of about 679,466 (304)

Orthotopic liver transplantation in human-immunodeficiency-virus-positive patients in Germany [PDF]

, 2012
Objectives: This summary evaluates the outcomes of orthotopic liver transplantation (OLT) of HIV-positive patients in Germany. Methods: Retrospective chart analysis of HIV-positive patients, who had been liver-transplanted in Germany between July ...
Anadol, Evrim, Beckebaum, Susanne, Berg, C., Bickel, Markus, Ganten, Tom M., Hitzenbichler, Florian, Kalff, Jörg C., Kittner, Jens Martin, Manekeller, Steffen, Paul, Andreas, Radecke, Klaus, Rockstroh, Jürgen, Sauerbruch, Tilman, Spengler, Ulrich, Stoll, Matthias, Zoufaly, Alexander   +15 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The Model for End-Stage Liver Disease Accurately Predicts 90-Day Liver Transplant Wait-List Mortality in Atlantic Canada

Canadian Journal of Gastroenterology, 2011
OBJECTIVE: To determine the generalizability of the predictions for 90-day mortality generated by Model for End-stage Liver Disease (MELD) and the serum sodium augmented MELD (MELDNa) to Atlantic Canadian adults with end-stage liver disease awaiting ...
Paul Douglas Renfrew, Hude Quan, Christopher James Doig, Elijah Dixon, Michele Molinari   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The model for end-stage liver disease (MELD) [PDF]

Hepatology, 2007
Abstract The Model for End-stage Liver Disease (MELD) was initially created to predict survival in patients with complications of portal hypertension undergoing elective placement of transjugular intrahepatic portosystemic shunts.
Patrick S, Kamath, W Ray, Kim
openaire   +2 more sources

Intrarenal Resistance Index as a Prognostic Parameter in Patients with Liver Cirrhosis Compared with Other Hepatic Scoring Systems [PDF]

, 2012
Background and Aims: Patients with advanced liver cirrhosis who develop renal dysfunction have a poor prognosis. Elevated intrarenal resistance indices (RIs) due to renal vascular constriction have been described before in cirrhotic patients.
Bardi A, C. Kaiser, Colli A, Conn HO, European, Ginès A, Götzberger M, Hanley JA, Hanley JA, J. Singer, Kastelan S, M. Götzberger, Sacerdoti A, V. Gülberg, Wang Y   +14 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Liver Transplants for Alcoholic Liver Disease

Canadian Journal of Gastroenterology, 1991
Alcohol related end-stage liver disease is a principal cause of liver failure. The scarcity of donor livers and the predominance of alcohol related end-stage liver disease has raised the issue of including alcoholics as candidates for liver ...
RJ Fingerote, VG Bain, RN Fedorak
doaj   +1 more source

Baseline MELD score predicts hepatic decompensation during antiviral therapy in patients with chronic hepatitis C and advanced cirrhosis [PDF]

, 2013
Background and Aims: In patients with advanced liver cirrhosis due to chronic hepatitis C virus (HCV) infection antiviral therapy with peginterferon and ribavirin is feasible in selected cases only due to potentially life-threatening side effects ...
Dultz, Georg, Friedrich-Rust, Mireen, Herrmann, Eva, Hofmann, Wolf Peter, Kronenberger, Bernd, Sarrazin, Christoph, Seelhof, Martin, Teuber, Gerlinde, Vermehren, Johannes, Wagner, Michael von, Welker, Martin-Walter, Zeuzem, Stefan   +11 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source