Results 51 to 60 of about 188,726 (292)

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

HLA‐DR⁺ Tumor Cells Show an Association with a Distinct Immune Microenvironment and CD8⁺ T‐Cell Exhaustion in HBV‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study integrates scRNA‐seq, multiplex immunofluorescence, and clinical data to identify HLA‐DR⁺tumor cells uniquely enriched in Hepatocellular carcinoma (HCC) with hepatitis B virus (HBV). These cells express MHC II, associate with PD‐L1, recruit and exhaust CD8⁺T cells, predict poor survival, and serve as potential biomarkers for immunotherapy ...
Jun‐Qing Chang, Yan Guo, Wen‐Jing Yuan, Yu‐Man Chen, Bo‐Wei Liu, Wen‐Tao Li, Xiang‐Ming Ding, Xu‐Dong Fu, Yu‐Han Lou, Zhuo‐Ran Chen, Xiao‐Ying Luo, Song‐Ze Ding, Bing‐Yong Zhang, Xiu‐Ling Li, Yong‐Zhi Hong, Shun‐Dong Cang, Dong‐Xiao Li, Ling Lan   +17 more
wiley   +1 more source

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

Advanced Science, EarlyView.
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang, Jingsong Liu, Pengfei Li, Zhibin Peng, Yubo Zhang, Yishu Liu, Mi Li, Xuqiang Gong, Daqian Liu, Enze Xu, Hongbo Yang, Yuanliang Sun, Yan Xu, Yansong Wang   +13 more
wiley   +1 more source

Neuritin Inhibits Notch Signaling through Interacted with Neuralized to Promote the Neurite Growth

Frontiers in Molecular Neuroscience, 2017
Neuritin plays a key role in neural development and regeneration by promoting neurite outgrowth and synapse maturation. However, the mechanism of neuritin in modulating neurite growth has not been elucidated.
Pan Zhang, Xing Luo, Zheng Guo, Anying Xiong, Hongchang Dong, Qiao Zhang, Chunyan Liu, Jingling Zhu, Haiyan Wang, Na Yu, Jinli Zhang, Yu Hong, Lei Yang, Jin Huang   +13 more
doaj   +1 more source

An integrative analysis of DNA methylation and transcriptome showed the dysfunction of MAPK pathway was involved in the damage of human chondrocyte induced by T-2 toxin

BMC Molecular and Cell Biology, 2022
Background T-2 toxin is thought to induce the growth plate and articular cartilage damage of Kashin-Beck disease (KBD), an endemic osteochondropathy in China.
Xuena Yang, Xue Xiao, Lu Zhang, Bo Wang, Ping Li, Bolun Cheng, Chujun Liang, Mei Ma, Xiong Guo, Feng Zhang, Yan Wen   +10 more
doaj   +1 more source

Endemic Diseases and Agriculture

, 2019
Endemic diseases are permanently present in a given population and at steady and predictable levels. In low- and middle-income countries these levels are usually higher, and some diseases only exist in those countries. They impact human livelihoods directly either through causing diseases (zoonoses) or severe economic losses.
openaire   +3 more sources

Widened Attention‐Enhanced Atrous Convolutional Network for Efficient Embedded Vision Applications under Resource Constraints

Advanced Intelligent Systems, EarlyView.
The article introduces WACEfNet, a new convolutional neural network architecture optimized for efficient aerial image analysis under resource constraints. It creatively integrates attention mechanisms and atrous convolutions into a compact widened residual network framework.
Md Meftahul Ferdaus, Mahdi Abdelguerfi, Kendall N. Niles, Ken Pathak, Joe Tom   +4 more
wiley   +1 more source

Deaths of Children in Out‐of‐Home‐Care: What do Inquest Reports Reveal About the Framing of Child Protection Practice?

Australian Journal of Social Issues, EarlyView.
ABSTRACT In Western Australia (WA), a coronial inquest into the death of a child who had been in care is mandatory. An inquest is a public hearing, a fact‐finding process to determine the cause of the death, prevent future deaths from occurring in similar circumstances and to comment on the public health implications.
Celine Harrison, Maria Harries, Mark Liddiard   +2 more
wiley   +1 more source

Molecular Evidence of High Proportion of Plasmodium vivax Malaria Infection in White Nile Area in Sudan

Journal of Parasitology Research, 2016
Plasmodium falciparum is a predominant malaria species that infects humans in the African continent. A recent WHO report estimated 95% and 5% of P. falciparum and P. vivax malaria cases, respectively, in Sudan.
Makarim M. Adam Suliman, Bushra M. Hamad, Musab M. Ali Albasheer, Maytha Elhadi, Mutaz Amin Mustafa, Maha Elobied, Muzamil Mahdi Abdel Hamid   +6 more
doaj   +1 more source

Bioinformatics prediction and experimental verification identify MAD2L1 and CCNB2 as diagnostic biomarkers of rhabdomyosarcoma

Cancer Cell International, 2021
Background Rhabdomyosarcoma (RMS) is a malignant soft-tissue tumour. In recent years, the tumour microenvironment (TME) has been reported to be associated with the development of tumours.
Tian Xia, Lian Meng, Zhijuan Zhao, Yujun Li, Hao Wen, Hao Sun, Tiantian Zhang, Jingxian Wei, Feng Li, Chunxia Liu   +9 more
doaj   +1 more source