Results 81 to 90 of about 46,789 (231)

Obesity-induced changes in lipid mediators persist after weight loss. [PDF]

, 2017
BackgroundObesity induces significant changes in lipid mediators, however, the extent to which these changes persist after weight loss has not been investigated.Subjects/methodsWe fed C57BL6 mice a high-fat diet to generate obesity and then switched the ...
Börgeson, E, Hernandez-Carretero, A, La Frano, MR, Lantero Rodriguez, J, Newman, JW, Osborn, O, Sears, DD, Wallenius, V, Weber, N, Ying, W   +9 more
core   +2 more sources

Commentary: Comment on the Effect of Endocannabinoid System on Rat Behavior

Basic and Clinical Neuroscience, 2017
I read the recently published article in Vol 6 (3) of Basic and Clinical Neuroscience entitled “Study the Effect of Endocannabinoid System on Rat Behavior in Elevated Plus- Maze” by Komaki et al. (2015).
Ali Roohbakhsh
doaj  

The Endocannabinoid System as a Potential Mechanism through which Exercise Influences Episodic Memory Function

Brain Sciences, 2019
Emerging research demonstrates that exercise, including both acute and chronic exercise, may influence episodic memory function. To date, mechanistic explanations of this effect are often attributed to alterations in long-term potentiation, neurotrophic ...
Paul D. Loprinzi, Liye Zou, Hong Li
doaj   +1 more source

Phytocannabinoids as novel therapeutic agents in CNS disorders [PDF]

, 2012
The Cannabis sativa herb contains over 100 phytocannabinoid (pCB) compounds and has been used for thousands of years for both recreational and medicinal purposes.
Hill, Andrew J., Stephens, Gary J., Whalley, Benjamin J., Williams, Claire M.   +3 more
core   +1 more source

The Endocannabinoid System and Energy Metabolism [PDF]

Journal of Neuroendocrinology, 2008
Many different regulatory actions have been attributed to endocannabinoids, and their involvement in several pathophysiological conditions is under intense scrutiny. Cannabinoid receptors [cannabinoid receptor type 1 (CB1) and CB2] participate in the physiological modulation of many central and peripheral functions.
Bellocchio L., CERVINO, CRISTINA, PASQUALI, RENATO, PAGOTTO, UBERTO   +3 more
openaire   +3 more sources

5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli, Deborah Rudin, Dino Luethi, Matthias E. Liechti, Sabrine Bilel, Matteo Marti, Henrik Green, Manuela Carla Monti, Caitlyn Norman   +8 more
wiley   +1 more source

Effects of endocannabinoid system modulation on cognitive and emotional behavior

Frontiers in Behavioral Neuroscience, 2011
Cannabis has long been known to produce cognitive and emotional effects. Research has shown that cannabinoid drugs produce these effects by driving the brain's endogenous cannabinoid system and that this system plays a modulatory role in many cognitive ...
Claudio eZanettini, Leigh V. Panlilio, Manó eAliczki, Steven R. Goldberg, Jozsef eHaller, Sevil eYasar   +5 more
doaj   +1 more source

Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex [PDF]

, 2018
Background Clinical reports suggest that rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become more potent. We hypothesize that stress-induced increases in corticosterone “set the
Baker, David A., Cravatt, Benjamin F., Doncheck, Elizabeth M., Graf, Evan N., Hillard, Cecilia J., Li, Yan, Liu, Qing-Song, Mantsch, John R., McReynolds, Jayme R., Ogasawara, Daisuke, Vranjkovic, Oliver   +10 more
core   +1 more source

mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]

, 2018
Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua, Gardner, Eliot L, He, Yi, Jordan, Chloe J, Li, Jie, Li, Xia, Peng, Xiao-Qing, Xi, Zheng-Xiong, Yang, Hong-Ju, Zhang, Hai-Ying   +9 more
core   +2 more sources

LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55‐Mediated Signalling in Spinal Cord Injury

Cell Proliferation, EarlyView.
LPC18:0 secreted by exogenous neural stem cells potentiates neurogenesis via the GPR55/AKT/GSK3β signalling axis, which ultimately promotes spinal cord injury recovery. ABSTRACT Spinal cord injury (SCI) is a devastating condition with limited therapeutic options. Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy
Dong Chen, Shuo Liu, Le‐Yi Tu, Ming‐Mei Yang, Cong‐Wang Xu, Yue Jiang, Hui Yang, Chen‐Xu Tai, Yan‐Ning Wang, Yuan‐Yuan Xie, Ping‐Ping Shen, Bin Wang   +11 more
wiley   +1 more source